Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Jingying Jia"'
Publikováno v:
Animal Bioscience, Vol 37, Iss 3, Pp 509-521 (2024)
Objective It was shown that microRNAs (miRNAs) play an important role in milk protein synthesis. However, the post-transcriptional regulation of casein expression by exogenous miRNA (xeno-miRNAs) in ruminants remains unclear. This study explores the
Externí odkaz:
https://doaj.org/article/c92e7f352c8545e5aff49c25aa4246e6
Autor:
Yun Liu, Wei Wang, Hongjie Qian, Yuzhou Gui, Yating Wang, Rong Song, Qian Chen, Eric Rowinsky, Sheng Wang, Xiaoguang Liang, Kaicun Gu, Bo Zhou, Weiwei Zhang, Liqin Zhang, Chen Yu, Jingying Jia
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 3, Pp n/a-n/a (2024)
Abstract This study evaluated the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and food effects (FE) of SC0062, a highly active endothelin‐A (ETA) receptor antagonist, in healthy subjects. The primary objectives of this first
Externí odkaz:
https://doaj.org/article/f1f117802baf44e7857f348d41657239
Autor:
Hongjie Qian, Jie Cheng, Yuzhou Gui, Wei Wang, Liyu Liang, Huijuan Zhu, Qingqing Wu, Meixian Ou, Qian Chen, Chen Yu, Jingying Jia
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 9, Pp 1704-1712 (2023)
Abstract This study aimed to evaluate the pharmacokinetic (PK) similarity of the proposed biosimilar HS628 compared with the reference tocilizumab (Actemra®) and also to demonstrate similar safety and immunogenicity profiles in healthy Chinese male
Externí odkaz:
https://doaj.org/article/3a81076c66c0476f8ed34e304c4e3c9d
Autor:
Qian Chen, Qingqing Wu, Rong Song, Yating Wang, Mengqi Zhang, Fangqiong Li, Weifang Zeng, Wei Wang, Jingying Jia, Chen Yu, Yanmei Liu
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Purpose: HSK16149 is a novel, potent gamma-aminobutyric acid (GABA) analog for the treatment of neuropathic pain. This study aimed to evaluate the safety, tolerability, and pharmacokinetics of HSK16149 after single and multiple doses in healthy Chine
Externí odkaz:
https://doaj.org/article/4c64b84e2fb946378319f666f04f86cd
Autor:
Qingqing Wu, Huijuan Zhu, Rong Song, Mengqi Zhang, Fangqiong Li, Weifang Zeng, Wei Wang, Jingying Jia, Chen Yu, Yanmei Liu
Publikováno v:
Pharmacology Research & Perspectives, Vol 11, Iss 3, Pp n/a-n/a (2023)
Abstract HSK16149 is a novel, potent gamma‐aminobutyric acid (GABA) analog for the treatment of neuropathic pain. The purpose of this study was to assess the effect of a high‐fat and high‐calorie meal on the pharmacokinetics of HSK16149 in heal
Externí odkaz:
https://doaj.org/article/9e8ee782ca8546018991dde952fa67a8
Autor:
Yanmei Liu, Sylvie Retout, Vincent Duval, Jingying Jia, Yang Zou, Yijun Wang, Valérie Cosson, Sébastien Jolivet, Stefan De Buck
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 5, Pp 1196-1203 (2022)
Abstract Baloxavir marboxil is an endonuclease inhibitor indicated for the treatment of influenza in patients ≥12 years. No data exist for Chinese patients in global studies. This randomized, open‐label, phase I study evaluated the pharmacokineti
Externí odkaz:
https://doaj.org/article/5dbacb0d156b40308aade476520953a7
Autor:
Yanmei Liu, Jie Cheng, Liyu Liang, Weigang Qian, Meixian Ou, Mengqi Zhang, Yijun Wang, Yan Wang, Ka Peng, Jingying Jia
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0284576 (2023)
ObjectivesTo compare the rate and extent of absorption of a launched generic calcium dobesilate capsule versus the branded reference formulation under fasting and fed conditions in healthy Chinese subjects, and to assess their bioequivalence and tole
Externí odkaz:
https://doaj.org/article/447a501bf07d48e68d369cf0687da8fb
Publikováno v:
Metabolites, Vol 13, Iss 1, p 76 (2023)
It was shown that microRNAs (miRNAs) play an important role in the synthesis of milk fat; thus, this manuscript evaluated whether exogenous miRNA (xeno-miRNAs) from alfalfa could influence the milk fat content in dairy cows. At first, mtr-miR168b was
Externí odkaz:
https://doaj.org/article/3ccf91571dcd45c883fce269e9f651df
Autor:
Yuzhou Gui, Youli Lu, Shuijun Li, Mengqi Zhang, Xiaokun Duan, Charles C. Liu, Jingying Jia, Gangyi Liu
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract Therapeutic drug monitoring (TDM) is necessary for the optimal administration of anti-arrhythmic drugs in the treatment of heart arrhythmia. The present study aimed to develop and validate a direct analysis in real time tandem mass spectrome
Externí odkaz:
https://doaj.org/article/385224b5c9f14bb1bbfb7fe826e73ea5
Autor:
Xiaoyan Song, Dongmei Wang, Baji Ben, Chenghua Xiao, Liyan Bai, Han Xiao, Wenyan Zhang, Wanchao Li, Jingying Jia, Yujuan Qi
Publikováno v:
Journal of International Medical Research, Vol 49 (2021)
Objective To investigate the associations between interleukin (IL) gene polymorphisms and susceptibility to gastric cancer in the Qinghai population, China. Methods Patients with gastric cancer and cancer-free controls were enrolled into the study fr
Externí odkaz:
https://doaj.org/article/41a84d8693c54d9ea2df2012e7838885