Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Jingxuan Shan"'
Autor:
Lilia Romdhane, Sameh Kefi, Nessrine Mezzi, Najla Abassi, Haifa Jmel, Safa Romdhane, Jingxuan Shan, Lotfi Chouchane, Sonia Abdelhak
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Admixture mapping has been useful in identifying genetic variations linked to phenotypes, adaptation and diseases. Copy number variations (CNVs) represents genomic structural variants spanning large regions of chromosomes reaching several me
Externí odkaz:
https://doaj.org/article/74ddedd6d9b74cfca46ce714398b9c4f
Autor:
Yujing Gao, Yujie Fang, Yongli Huang, Rui Ma, Xixi Chen, Fang Wang, Xiuying Pei, Yuanqi Gao, Xuehua Chen, Xinrui Liu, Jingxuan Shan, Pu Li
Publikováno v:
Cell Death and Disease, Vol 13, Iss 9, Pp 1-14 (2022)
Abstract Migration and invasion inhibitory protein (MIIP) has been identified as a tumor suppressor in various cancer types. Although MIIP is reported to exert tumor suppressive functions by repressing proliferation and metastasis of cancer cells, th
Externí odkaz:
https://doaj.org/article/db8aaf5cf24f457eb8e5209c0d7540d6
Autor:
Lilia Romdhane, Nessrine Mezzi, Hamza Dallali, Olfa Messaoud, Jingxuan Shan, Khalid A. Fakhro, Rym Kefi, Lotfi Chouchane, Sonia Abdelhak
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-18 (2021)
Abstract Copy number variation (CNV) is considered as the most frequent type of structural variation in the human genome. Some CNVs can act on human phenotype diversity, encompassing rare Mendelian diseases and genomic disorders. The North African po
Externí odkaz:
https://doaj.org/article/399d7564503448b8a9d14b264646b319
Precision medicine in the era of artificial intelligence: implications in chronic disease management
Autor:
Murugan Subramanian, Anne Wojtusciszyn, Lucie Favre, Sabri Boughorbel, Jingxuan Shan, Khaled B. Letaief, Nelly Pitteloud, Lotfi Chouchane
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-12 (2020)
Abstract Aberrant metabolism is the root cause of several serious health issues, creating a huge burden to health and leading to diminished life expectancy. A dysregulated metabolism induces the secretion of several molecules which in turn trigger th
Externí odkaz:
https://doaj.org/article/7474f0910e8b4a6cb0f759f4b08eb8a3
Autor:
Silvia Ghione, Cindy Racoeur, Nesrine Mabrouk, Jingxuan Shan, Emma Groetz, Elise Ballot, Caroline Truntzer, Lotfi Chouchane, Frédérique Végran, Catherine Paul, Stéphanie Plenchette, Ali Bettaieb
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immunotherapy has allowed major advances in oncology in the past years, in particular with the development of immune checkpoint inhibitors, but the clinical benefits are still limited, particularly in colorectal cancer (CRC). Our scientific approach
Externí odkaz:
https://doaj.org/article/2341957bf72b4c7e87e49db9cfb8f168
Autor:
Lotfi Chouchane, Jean-Charles Grivel, Elmoubasher Abu Baker Abd Farag, Igor Pavlovski, Selma Maacha, Abbirami Sathappan, Hamad Eid Al-Romaihi, Sirin W.J. Abuaqel, Manar Mahmoud Ahmad Ata, Aouatef Ismail Chouchane, Sami Remadi, Najeeb Halabi, Arash Rafii, Mohammed H. Al-Thani, Nico Marr, Murugan Subramanian, Jingxuan Shan
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
The development of prophylactic and therapeutic agents for coronavirus disease 2019 (COVID-19) is a current global health priority. Here, we investigated the presence of cross-neutralizing antibodies against severe acute respiratory syndrome coronavi
Externí odkaz:
https://doaj.org/article/78735e02d86248bba861c7d04c9abd1f
Autor:
Govinda Lenka, Jingxuan Shan, Najeeb Halabi, Sirin W J Abuaqel, Neha Goswami, Frank Schmidt, Shaza Zaghlool, Atilio Reyes Romero, Murugan Subramanian, Salha Boujassoum, Issam Al‐Bozom, Salah Gehani, Noor Al Khori, Davide Bedognetti, Karsten Suhre, Xiaojing Ma, Alexander Dömling, Arash Rafii, Lotfi Chouchane
Publikováno v:
Clinical and Translational Medicine, Vol 10, Iss 3, Pp n/a-n/a (2020)
Abstract Background Although autophagy plays a dual role in suppressing or promoting certain cancers, the nature of its involvement in breast cancers remains unclear. Here, we investigated the function of STXBP6, a protein regulating the autophagy‐
Externí odkaz:
https://doaj.org/article/99eb919059fc445a90aca3bb0a20d936
Autor:
Sayeeda Hana, Deepak karthik, Jingxuan Shan, Stephany El Hayek, Lotfi Chouchane, André Megarbane
Publikováno v:
Case Reports in Medicine, Vol 2020 (2020)
Recessive mutations in the TMTC3 gene have been reported in thirteen patients to date exhibiting development delay, intellectual disability (ID), seizures, and muscular hypotonia, accompanied occasionally by neuronal migration defects expressed as ei
Externí odkaz:
https://doaj.org/article/3b06c9ec25484a10a95640bdd4eccaf3
Autor:
Jingxuan Shan, Aziz Chouchane, Younes Mokrab, Mohamad Saad, Salha Boujassoum, Rosalyn W. Sayaman, Elad Ziv, Noureddine Bouaouina, Yasmine Remadi, Sallouha Gabbouj, Jessica Roelands, Xiaojing Ma, Davide Bedognetti, Lotfi Chouchane
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Triple-negative breast cancer (TNBC) accounts for ~15–20% of breast cancer (BC) and has a higher rate of early relapse and mortality compared to other subtypes. The Chemokine (C-C motif) ligand 5 (CCL5) and its signaling pathway have been linked to
Externí odkaz:
https://doaj.org/article/4946a6389cb944f4bf59218bb7372cf5
Autor:
Jingxuan Shan, Khalid Al-Rumaihi, Karim Chouchane, Issam Al-Bozom, Danny Rabah, Karim Farhat, Lotfi Chouchane
Publikováno v:
Journal of Translational Medicine, Vol 15, Iss 1, Pp 1-11 (2017)
Abstract Background Prostate cancer (PCa) is a complex disorder resulting from the combined effects of multiple environmental and genetic factors. Small non-coding RNAs (sRNAs), particularly microRNAs (miRNAs), regulate several cellular processes and
Externí odkaz:
https://doaj.org/article/2b4a814b0ad749e882c05c4b90a43112