Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Jingwu Z. Zhang"'
Autor:
Xi Chen, Lin Shen, Cheng Zhang, Jing Gao, Wenqing Jiang, Zhengyi Wang, Jaeho Jung, Chan Chen, Xuejun Liu, Yanni Zhang, Eunsil Sung, Zhen Sheng, Zhen Meng, Yanling Niu, Chanjuan Liu, Keren Jia, Haiyan Liao, Hyejin Chung, Jingwu Z. Zhang, Andrew X. Zhu
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 6 (2023)
Background Claudin18.2 (CLDN18.2) is a tight junction protein that has been identified as a clinically proven target in gastric cancer. Stimulation of 4-1BB with agonistic antibodies is also a promising strategy for immunotherapy and 4-1BB+ T cells w
Externí odkaz:
https://doaj.org/article/58dde64dd10b49928f0d7b67756c8c60
Publikováno v:
AIMS Medical Science, Vol 3, Iss 1, Pp 103-113 (2016)
Objective: Human IL-18BP gene encodes at least four distinct isoforms (IL18BPa-d) derived by alternative splicing. Their presence in RA local inflammation is not yet examined. This study aimed to determine the messenger transcript and protein levels
Externí odkaz:
https://doaj.org/article/bb537679941e4427b036cf19935e7a5f
Publikováno v:
AIMS Medical Science, Vol 3, Iss 1, Pp 103-113 (2016)
Objective: Human IL-18BP gene encodes at least four distinct isoforms (IL18BPa-d) derived by alternative splicing. Their presence in RA local inflammation is not yet examined. This study aimed to determine the messenger transcript and protein levels
Publikováno v:
Trends in Immunology. 34:120-128
In autoimmune disease, a network of diverse cytokines is produced in association with disease susceptibility to constitute the 'cytokine milieu' that drives chronic inflammation. It remains elusive how cytokines interact in such a complex network to
Publikováno v:
Journal of Molecular Cell Biology. 5:85-98
Deficiency in the TGF-β-induced regulatory T (iTreg) cell differentiation is associated with compromised immune homeostasis and plays a key role in many autoimmune diseases. Therapeutic intervention to enhance in situ iTreg differentiation has becom
Publikováno v:
Immunome Research. 12
Autor:
Wei Cao, Zhengyi Wang, Yiqing Yang, Ailian Liu, Chen Dong, Yufang Shi, Jingwu Z Zhang, Fenglan Wu, Stewart Leung, Jian Hong, Lei Fang
Publikováno v:
Immunity. 35:273-284
SummaryNeural progenitor cell (NPC) therapy is considered a promising treatment modality for multiple sclerosis (MS), potentially acting through neural repair. Here, we showed that intravenous administration of NPCs ameliorated experimental autoimmun
Publikováno v:
Cellular & Molecular Immunology. 7:182-189
The propagation and regulation of an immune response is driven by a network of effector and regulatory T (Treg) cells. The interplay of effector T and Treg cells determines the direction of the immune response towards inflammation or its resolution i
Autor:
Hongtao Lu, Runsheng Li, Limin Lu, Taylor B Guo, Bing Wan, Jian Hong, Mingjuan Song, Ji Wang, Lei Fang, Xuebin Liu, Chunxia Wang, Stewart Leung, Jingwu Z Zhang, Ailian Liu, Yonggang Zhao, Xia Qin, Zhu Tan, Heng Pan
Publikováno v:
Nature Medicine. 16:191-197
Interleukin-7 receptor (IL-7R) is genetically associated with susceptibility to multiple sclerosis. Here we describe that IL-7 is essential for survival and expansion of pathogenic T helper type 17 (T(H)17) cells in experimental autoimmune encephalom
Publikováno v:
The Journal of Immunology. 183:246-253
Th17 and Th1 play an important role in multiple sclerosis for which copolymer I (COP-I) is a treatment option. We described here that the treatment effect of COP-I correlated with its unique regulatory properties on differentiation and survival of Th