Modelling pulmonary microthrombosis coupled to metastasis: distinct effects of thrombogenesis on tumorigenesis

Autor: Colin E. Evans, Asis Palazon, Jingwei Sim, Petros A. Tyrakis, Alice Prodger, Xiao Lu, Saria Chan, Pär-Ola Bendahl, Mattias Belting, Love Von Euler, Helene Rundqvist, Randall S. Johnson, Cristina Branco

Publikováno v: Biology Open, Vol 6, Iss 5, Pp 688-697 (2017)

Thrombosis can cause localized ischemia and tissue hypoxia, and both of these are linked to cancer metastasis. Vascular micro-occlusion can occur as a result of arrest of circulating tumour cells in small capillaries, giving rise to microthrombotic e

Externí odkaz: https://doaj.org/article/4bb30084d1524fcabf20b1feeab2ac4f

Use of Phenobarbitone for Palliative Sedation in Dyspneic Crises Due to COVID-19 Pneumonia – A Case Series

Autor: Jingwei Sim, Wen Yang Goh, Lynn Wiryasaputra, Allyn Yin-Mei Hum, Han Yee Neo, Choo Hwee Poi

Publikováno v: Journal of Pain & Palliative Care Pharmacotherapy. 36:242-248

Patients who suffer from dyspnea while dying from COVID-19 are treated with opioids and benzodiazepines. In some instances, patients may experience refractory dyspnea at the end of life. Palliative sedation can be prescribed to alleviate such patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a022988f50b19a98a82e98ea79cb003
https://doi.org/10.1080/15360288.2022.2113596

A case of rapidly progressive insomnia and dysautonomia

Autor: Jingwei Sim, Kok Pin Yong, Kaavya Narasimhalu

Publikováno v: Annals of the Academy of Medicine, Singapore. 51(8)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe5f2335af9abe1f5b34b86b1117641d
https://pubmed.ncbi.nlm.nih.gov/36047528

Assessment of small intestinal bacterial overgrowth in Alzheimer's disease

Autor: Jingwei, Sim, Yu Tien, Wang, Kaysar, Mamun, Sze Yan, Tay, Kinjal, Doshi, Shahul, Hameed, Simon Kang-Seng, Ting

Publikováno v: Acta neurologica Taiwanica. 30

There is great interest in crosstalk between the gastrointestinal and immune systems. Small intestinal bacterial overgrowth (SIBO) is a bowel disorder prevalent among patients with Parkinson's disease; SIBO treatment has been shown to modulate neurol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::39c02db59905f62a92440e0d6a049d9c
https://pubmed.ncbi.nlm.nih.gov/34841505

The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia

Autor: Basetti Madhu, Thaksaon Kittipassorn, Sandra Pietsch, Colin E. Evans, David Macías, Michael Gralla, Yu C.J. Chey, Asis Palazon, Andrew S. Cowburn, David Bargiela, Randall S. Johnson, Cristina Branco, Petros A. Tyrakis, Helene Rundqvist, Jingwei Sim, Daniel J. Peet

Publikováno v: Sim, J, Cowburn, A S, Palazon, A, Madhu, B, Tyrakis, P A, Macías, D, Bargiela, D M, Pietsch, S, Gralla, M, Evans, C E, Kittipassorn, T, Chey, Y C J, Branco, C M, Rundqvist, H, Peet, D J & Johnson, R S 2018, ' The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia ', Cell metabolism, vol. 27, no. 4, pp. 898-913.e7 . https://doi.org/10.1016/j.cmet.2018.02.020
913.e7
Cell Metabolism

Summary Animals require an immediate response to oxygen availability to allow rapid shifts between oxidative and glycolytic metabolism. These metabolic shifts are highly regulated by the HIF transcription factor. The factor inhibiting HIF (FIH) is an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8706c923a7a7d9345c90089b881de452
https://pure.qub.ac.uk/en/publications/the-factor-inhibiting-hif-asparaginyl-hydroxylase-regulates-oxidative-metabolism-and-accelerates-metabolic-adaptation-to-hypoxia(a7627603-b98d-44db-bd83-cf0c42ec4e3e).html