A novel mouse model of upper tract urothelial carcinoma highlights the impact of dietary intervention on gut microbiota and carcinogenesis prevention despite carcinogen exposure.

Autor: Yamamoto A; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan., Kawashima A; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan., Uemura T; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan., Nakano K; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan., Matsushita M; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan., Ishizuya Y; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan., Jingushi K; Laboratory of Molecular and Cellular Physiology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan., Hase H; Laboratory of Molecular and Cellular Physiology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan., Katayama K; Laboratory of Sequence Analysis, Human Genome Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Yamaguchi R; Division of Cancer Systems Biology, Aichi Cancer Center Research Institute, Nagoya, Japan.; Division of Cancer Informatics, Nagoya University Graduate School of Medicine, Nagoya, Japan., Sassi N; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan., Motoyama Y; Department of Pathology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan., Nojima S; Department of Pathology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan., Mita M; KAGAMI Inc., Ibaraki, Osaka, Japan., Kimura T; Department of Nephrology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan., Motooka D; Department of Infection Metagenomics, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan., Horibe Y; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan., Okuda Y; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan., Oka T; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan., Yamamichi G; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan., Tomiyama E; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan., Koh Y; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan., Yamamoto Y; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan., Kato T; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan., Hatano K; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan., Uemura M; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan., Imoto S; Laboratory of Sequence Analysis, Human Genome Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Division of Health Medical Intelligence, Human Genome Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Wada H; Department of Clinical Research in Tumor Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan., Morii E; Department of Pathology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan., Tsujikawa K; Laboratory of Molecular and Cellular Physiology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan., Nonomura N; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.

Publikováno v: International journal of cancer [Int J Cancer] 2024 Dec 18. Date of Electronic Publication: 2024 Dec 18.

Small extracellular vesicles carrying reovirus, tumor antigens, interferon-β, and damage-associated molecular patterns for efficient tumor treatment.

Autor: Shuwari N; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan., Inoue C; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan., Ishigami I; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan., Jingushi K; Laboratory of Molecular and Cellular Physiology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan., Kamiya M; Department of Pharmaceutical Informatics, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki-shi, Nagasaki 852-8588, Japan., Kawakami S; Department of Pharmaceutical Informatics, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki-shi, Nagasaki 852-8588, Japan., Tsujikawa K; Laboratory of Molecular and Cellular Physiology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan., Tachibana M; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan; The Center for Advanced Medical Engineering and Informatics, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan., Mizuguchi H; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan; The Center for Advanced Medical Engineering and Informatics, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan; Laboratory of Functional Organoid for Drug Discovery, Center for Drug Discovery Resources Research, National Institute of Biomedical Innovation, Health and Nutrition, 7-6-8 Saito, Asagi, Ibaraki, Osaka 567-0085, Japan; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Osaka 565-0871, Japan; Center for Infectious Disease Education and Research (CiDER), Osaka University, Osaka 565-0871, Japan., Sakurai F; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address: sakurai@phs.osaka-u.ac.jp.

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2024 Oct; Vol. 374, pp. 89-102. Date of Electronic Publication: 2024 Aug 10.

Bacteria-derived DNA in serum extracellular vesicles are biomarkers for renal cell carcinoma.

Autor: Uemura T; Department of Urology, Osaka University, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan., Kawashima A; Department of Urology, Osaka University, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan., Jingushi K; Laboratory of Molecular and Cellular Physiology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan., Motooka D; Department of Infection Metagenomics, Genome Information Research Center, Osaka University Research Institute for Microbial Diseases, Suita, Osaka, 565-0871, Japan., Saito T; Department of Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan.; Department of Clinical Research in Tumor Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan., Nesrine S; Department of Urology, Osaka University, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan., Oka T; Department of Urology, Osaka University, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan., Okuda Y; Department of Urology, Osaka University, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan., Yamamoto A; Department of Urology, Osaka University, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan., Yamamichi G; Department of Urology, Osaka University, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan., Tomiyama E; Department of Urology, Osaka University, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan., Ishizuya Y; Department of Urology, Osaka University, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan., Yamamoto Y; Department of Urology, Osaka University, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan., Kato T; Department of Urology, Osaka University, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan., Hatano K; Department of Urology, Osaka University, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan., Tsujikawa K; Laboratory of Molecular and Cellular Physiology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan., Wada H; Department of Clinical Research in Tumor Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan., Nonomura N; Department of Urology, Osaka University, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Publikováno v: Heliyon [Heliyon] 2023 Sep 06; Vol. 9 (9), pp. e19800. Date of Electronic Publication: 2023 Sep 06 (Print Publication: 2023).

P196 - D-asparagine could become a novel blood-based diagnostic marker for urothelial carcinoma patients

Autor: Kawashima, A., Yamamoto, A., Kimura, T., Mita, M., Jingushi, K., Horibe, Y., Sassi, N., Uemura, T., Tani, M., Yoshimura, A., Oka, T., Okuda, Y., Yamamichi, G., Ishizuya, Y., Yamamoto, Y., Kato, T., Hatano, K., Nonomura, N.

Publikováno v: In European Urology Open Science November 2023 57 Supplement 1:S272-S272

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