Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Jingtao Lilue"'
Autor:
Eileen A. Moran, Karen Salas-Briceno, Wenming Zhao, Takuji Enya, Alexya N. Aguilera, Ivan Acosta, Francis Alonzo, Dara Kiani, Judith Behnsen, Catalina Alvarez, Thomas M. Keane, David J. Adams, Jingtao Lilue, Susan R. Ross
Publikováno v:
mBio, Vol 15, Iss 7 (2024)
ABSTRACT Mammalian AIM-2-like receptor (ALR) proteins bind nucleic acids and initiate production of type I interferons or inflammasome assembly, thereby contributing to host innate immunity. In mice, the Alr locus is highly polymorphic at the sequenc
Externí odkaz:
https://doaj.org/article/dc580ccc007e4157abcf0818a77211f2
Autor:
Miriam Corraliza-Gomez, Teresa Bermejo, Jingtao Lilue, Noelia Rodriguez-Iglesias, Jorge Valero, Irene Cozar-Castellano, Eduardo Arranz, Diego Sanchez, Maria Dolores Ganfornina
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-21 (2023)
Abstract The insulin-degrading enzyme (IDE) is an evolutionarily conserved zinc-dependent metallopeptidase highly expressed in the brain, where its specific functions remain poorly understood. Besides insulin, IDE is able to cleave many substrates in
Externí odkaz:
https://doaj.org/article/118154be055f4dffaa9df41623151dc5
Autor:
Elisa Jentho, António G.G. Sousa, Susana Ramos, Temitope W. Ademolue, João Sobral, João Costa, Denise Brito, Marta Manteiro, Ricardo B. Leite, Jingtao Lilue, Miguel P. Soares
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102491- (2023)
Summary: Bulk RNA sequencing of Plasmodium spp., the causative parasite of malaria, fails to discriminate developmental-stage-specific gene regulation. Here, we provide a protocol that uses single-cell RNA sequencing of FACS-sorted Plasmodium-chabaud
Externí odkaz:
https://doaj.org/article/11e92da0134448cab8351af798267c88
Autor:
Marta Alenquer, Filipe Ferreira, Diana Lousa, Mariana Valério, Mónica Medina-Lopes, Marie-Louise Bergman, Juliana Gonçalves, Jocelyne Demengeot, Ricardo B. Leite, Jingtao Lilue, Zemin Ning, Carlos Penha-Gonçalves, Helena Soares, Cláudio M. Soares, Maria João Amorim
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8 (2021)
Understanding SARS-CoV-2 evolution and host immunity is critical to control COVID-19 pandemics. At the core is an arms-race between SARS-CoV-2 antibody and angiotensin-converting enzyme 2 (ACE2) recognition, a function of the viral protein spike. Mut
Externí odkaz:
https://doaj.org/article/e0fcf74913e6441bbcba7b8241d921b4
Autor:
Rafael A. Paiva, António G.G. Sousa, Camila V. Ramos, Mariana Ávila, Jingtao Lilue, Tiago Paixão, Vera C. Martins
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108967- (2021)
Summary: T lymphocyte differentiation in the steady state is characterized by high cellular turnover whereby thymocytes do not self-renew. However, if deprived of competent progenitors, the thymus can temporarily maintain thymopoiesis autonomously. T
Externí odkaz:
https://doaj.org/article/380ece4bd87549e78c9ca22b083a0290
Publikováno v:
PLoS Genetics, Vol 15, Iss 11, p e1008446 (2019)
For over a century, mice have been used to model human disease, leading to many fundamental discoveries about mammalian biology and the development of new therapies. Mouse genetics research has been further catalysed by a plethora of genomic resource
Externí odkaz:
https://doaj.org/article/8ae93730721e42deb236817b9b9f3fc3
Publikováno v:
mBio, Vol 8, Iss 4 (2017)
ABSTRACT Cytosolic DNAs derived from retrotransposons serve as pathogen-associated molecular patterns for pattern recognition receptors (PRRs) that stimulate the induction of interferons (IFNs) and other cytokines, leading to autoimmune disease. Cycl
Externí odkaz:
https://doaj.org/article/d254c4edf75e434e8607b6b4b3122261
Autor:
Ximena Ibarra-Soria, Thiago S Nakahara, Jingtao Lilue, Yue Jiang, Casey Trimmer, Mateus AA Souza, Paulo HM Netto, Kentaro Ikegami, Nicolle R Murphy, Mairi Kusma, Andrea Kirton, Luis R Saraiva, Thomas M Keane, Hiroaki Matsunami, Joel Mainland, Fabio Papes, Darren W Logan
Publikováno v:
eLife, Vol 6 (2017)
The mouse olfactory sensory neuron (OSN) repertoire is composed of 10 million cells and each expresses one olfactory receptor (OR) gene from a pool of over 1000. Thus, the nose is sub-stratified into more than a thousand OSN subtypes. Here, we employ
Externí odkaz:
https://doaj.org/article/15a96e0e6af7466bb3e8a8110bb7da7a
Publikováno v:
eLife, Vol 2 (2013)
Virulence in the ubiquitous intracellular protozoon Toxoplasma gondii for its natural intermediate host, the mouse, appears paradoxical from an evolutionary standpoint because death of the mouse before encystment interrupts the parasite life cycle. V
Externí odkaz:
https://doaj.org/article/f2254b4ad77f4f59ade3b7303e0007e9
Autor:
Susana Ramos, Temitope W. Ademolue, Elisa Jentho, Qian Wu, Joel Guerra, Rui Martins, Gil Pires, Sebastian Weis, Ana Rita Carlos, Inês Mahú, Elsa Seixas, Denise Duarte, Fabienne Rajas, Sílvia Cardoso, António G.G. Sousa, Jingtao Lilue, Tiago Paixão, Gilles Mithieux, Fátima Nogueira, Miguel P. Soares
Publikováno v:
Cell Metabolism
Cell Metabolism, Elsevier, 2022, 34 (8), pp.1183-1200.e12. ⟨10.1016/j.cmet.2022.06.011⟩
Cell Metabolism, Elsevier, 2022, 34 (8), pp.1183-1200.e12. ⟨10.1016/j.cmet.2022.06.011⟩
Copyright © 2022 Elsevier Inc. All rights reserved. Hypoglycemia is a clinical hallmark of severe malaria, the often-lethal outcome of Plasmodium falciparum infection. Here, we report that malaria-associated hypoglycemia emerges from a non-canonical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51035d01e7de9e885c2628a44bae7472
https://hdl.handle.net/10362/142754
https://hdl.handle.net/10362/142754
