Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jingsong Fan"'
Autor:
Chiranjit Dutta, Pannaga Krishnamurthy, Dandan Su, Jianwei Li, Sung Hyun Yoo, Gavin W. Collie, Morgane Pasco, Jingsong Fan, Min Luo, Mihail Barboiu, Gilles Guichard, R. Manjunatha Kini, Prakash Kumar
Publikováno v:
Small Science, Vol 4, Iss 8, Pp n/a-n/a (2024)
Constructing artificial ion channels is a challenging task. Herein, the de novo design of transmembrane ion channels made up of amphiphilic peptide–oligourea chimeric helices is described. They consist of an oligourea segment (7‐mer) attached to
Externí odkaz:
https://doaj.org/article/385d9d2eb7dd4dbda9b4db8e193fffbb
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123934 (2015)
The partially disordered Chibby (Cby) is a conserved nuclear protein that antagonizes the Wnt/β-catenin signaling pathway. By competing with the Tcf/Lef family proteins for binding to β-catenin, Cby abrogates the β-catenin-mediated transcription o
Externí odkaz:
https://doaj.org/article/d6e0608d922549a99f0cfcf12260208a
Autor:
Georg Andrees Bohme, Jennifer B. Pierson, Sonja Stoelzle-Feix, Simon Hebeisen, Nina Brinkwirth, Carlos G. Vanoye, James Kramer, Gary Gintant, Jingsong Fan, Atsushi Ohtsuki, Dingzhou Li, Muthukrishnan Renganathan, Herbert M. Himmel, Bernard Fermini, Matthew Bridgland-Taylor, Edward Humphries, Khuram W. Chaudhary, John Imredy, Tim Strassmaier, Anders Lindqvist, Timm Danker, Liudmila Polonchuk
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
Automated patch clamp (APC) instruments enable efficient evaluation of electrophysiologic effects of drugs on human cardiac currents in heterologous expression systems. Differences in experimental protocols, instruments, and dissimilar site procedure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793dcd388f38431a41186ab3f240d140
https://doi.org/10.1038/s41598-020-62344-w
https://doi.org/10.1038/s41598-020-62344-w
Autor:
Nadine Becker, Mohammadreza Samieegohar, John Imredy, Jin Zhai, Anders Lindqvist, Søren Friis, Nina Brinkwirth, Tim Strassmaier, Jae Kwagh, James Kramer, Jingsong Fan, Paul Levesque, Sonja Stoelzle-Feix, Bradley J. Ridder, Herbert Himmel, Timm Danker, Derek J. Leishman, Markus Rapedius, Liudmila Polonchuk, Jiansong Sheng, Marc Rogers, Gary R. Mirams, Simon Hebeisen, Haiyang Wei, George Okeyo, Evgenia Gissinger, Tom A. Goetze, Phu N. Tran, Zhihua Li, Rémi Bardenet, Yuri A. Kuryshev, Muthukrishnan Renganathan, Maria Giustina Rotordam, Aaron Randolph, Daniel Konrad, Robert W. Kirby, Wendy W. Wu, Caiyun Wu, David G. Strauss, Matthew Bridgland-Taylor, Bryan Koci, Edward Humphries, Xiaomei Han
Publikováno v:
Toxicology and Applied Pharmacology
Toxicology and Applied Pharmacology, Elsevier, 2020, 394, pp.114961. ⟨10.1016/j.taap.2020.114961⟩
Toxicology and Applied Pharmacology, 2020, 394, pp.114961. ⟨10.1016/j.taap.2020.114961⟩
Toxicology and Applied Pharmacology, Elsevier, 2020, 394, pp.114961. ⟨10.1016/j.taap.2020.114961⟩
Toxicology and Applied Pharmacology, 2020, 394, pp.114961. ⟨10.1016/j.taap.2020.114961⟩
Introduction hERG block potency is widely used to calculate a drug's safety margin against its torsadogenic potential. Previous studies are confounded by use of different patch clamp electrophysiology protocols and a lack of statistical quantificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::944e258ca318d261e63e5e97ce793630
http://europepmc.org/articles/PMC7166077
http://europepmc.org/articles/PMC7166077
Publikováno v:
Journal of Physics: Conference Series. 2206:012019
In order to realize the collaborative operation between the physical prototype and the virtual prototype of industrial robot, a digital twin model of a six-degree-of-freedom industrial robot was established. The structure and motion parameters of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::355355789713346d3ca8aec3c0efc463
https://doi.org/10.1088/1742-6596/2206/1/012019
https://doi.org/10.1088/1742-6596/2206/1/012019
Publikováno v:
Journal of Physics: Conference Series. 2206:012027
In order to solve the problem of aerial photography imaging blur, an aerial camera optical image stabilization system is designed. Based on the principle of optical image stabilization, a forward image stabilization system of aerial camera was design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a593e03002cc9ac9d4b2af16b7254d5
https://doi.org/10.1088/1742-6596/2206/1/012027
https://doi.org/10.1088/1742-6596/2206/1/012027
Autor:
Regina Miller, Nicholas J. Lodge, John E. Macor, Wendy Clarke, Lizbeth Gallagher, Linda J. Bristow, Daniel G. Morgan, Christiana I. Iwuagwu, Ryan Westphal, Haiquan Fang, Kimberley A. Lentz, Debra J. Post-Munson, Amy Easton, Matthew D. Hill, Bei Wang, Robert A. Mate, Ivar M. McDonald, James H. Cook, Yulia Benitex, Dalton King, Thaddeus F. Molski, Ronald J. Knox, F. Christopher Zusi, Richard E. Olson, Rex Denton, Jingsong Fan, Rulin Zhao, Robert Zaczek
Publikováno v:
ACS Medicinal Chemistry Letters. 8:366-371
The therapeutic treatment of negative symptoms and cognitive dysfunction associated with schizophrenia is a significant unmet medical need. Preclinical literature indicates that α7 neuronal nicotinic acetylcholine (nACh) receptor agonists may provid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4993c640b254a344e08c8bc412ffe3
https://doi.org/10.1021/acsmedchemlett.7b00032
https://doi.org/10.1021/acsmedchemlett.7b00032
Autor:
Anders Lindqvist, Dingzhou Li, Jingsong Fan, Georg Andrees Bohme, Khuram W. Chaudhary, Muthukrishnan Renganathan, Atsushi Ohtsuki, James Kramer, John Imredy, Tim Strassmaier, Edward Humphries, Liudmila Polonchuk, Gary A. Gintant, Bernard Fermini, Jennifer B. Pierson, Timm Danker, Herbert M. Himmel, Sonja Stoelzle-Feix, Nina Brinkwirth, Simon Hebeisen, Carlos G. Vanoye, Matthew Bridgland-Taylor
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeac0116e9e606a1561ae6857caf2cb9
http://link.springer.com/article/10.1038/s41598-020-68819-0
http://link.springer.com/article/10.1038/s41598-020-68819-0
Autor:
Daniel Konrad, James Kramer, John Imredy, Anders Lindqvist, Haiyang Wei, Evgenia Gissinger, Tim Strassmaier, Jae Kwagh, Søren Friis, Aaron Randolph, Caiyun Wu, Muthukrishnan Renganathan, David G. Strauss, Jingsong Fan, Edward Humphries, George Okeyo, Timm Danker, Nina Brinkwirth, Bradley J. Ridder, Robert W. Kirby, Wendy W. Wu, Markus Rapedius, Phu N. Tran, Nadine Becker, Mohammadreza Samieegohar, Jiansong Sheng, Marc Rogers, Paul Levesque, Sonja Stoelzle-Feix, Herbert Himmel, Bryan Koci, Yuri A. Kuryshev, Matthew Bridgland-Taylor, Liudmila Polonchuk, Jin Zhai, Tom A. Goetze, Zhihua Li, Xiaomei Han, Simon Hebeisen, Rémi Bardenet, Gary R. Mirams, Maria Giustina Rotordam, Derek J. Leishman
Publikováno v:
Toxicology and Applied Pharmacology. 395:114983
© 2020 The Author(s) The authors regret that one affiliation address is mistaken in the published paper. Matthew Bridgland-Taylor's affiliation was incorrectly listed as Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Cambridge, United Ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9325ed3f56c1916f5af5315ccfb4082
https://doi.org/10.1016/j.taap.2020.114983
https://doi.org/10.1016/j.taap.2020.114983
Autor:
George Thalody, Paul Levesque, Jae Kwagh, Hong Shi, Jingsong Fan, Geoff Lewen, Elisabeth Burnett, Shen-Jue Chen
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 55
The purpose of these studies was to develop ex vivo tissue-based and in vitro cell-based assays using multi-electrode array (MEA) technology to predict seizure liability at the early stage of preclinical studies. Embryonic rat hippocampal neurons and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52073f132ed41dfcd98aa116ce89c6a8
https://pubmed.ncbi.nlm.nih.gov/30528373
https://pubmed.ncbi.nlm.nih.gov/30528373