Zobrazeno 1 - 10
of 173
pro vyhledávání: '"Jingshan Ren"'
Emerging variants develop total escape from potent monoclonal antibodies induced by BA.4/5 infection
Autor:
Chang Liu, Raksha Das, Aiste Dijokaite-Guraliuc, Daming Zhou, Alexander J. Mentzer, Piyada Supasa, Muneeswaran Selvaraj, Helen M. E. Duyvesteyn, Thomas G. Ritter, Nigel Temperton, Paul Klenerman, Susanna J. Dunachie, Neil G. Paterson, Mark A. Williams, David R. Hall, Elizabeth E. Fry, Juthathip Mongkolsapaya, Jingshan Ren, David I. Stuart, Gavin R. Screaton
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract The rapid evolution of SARS-CoV-2 is driven in part by a need to evade the antibody response in the face of high levels of immunity. Here, we isolate spike (S) binding monoclonal antibodies (mAbs) from vaccinees who suffered vaccine break-th
Externí odkaz:
https://doaj.org/article/cc28ab08066f4f34ade2b16555c78a91
Autor:
Daming Zhou, Piyada Supasa, Chang Liu, Aiste Dijokaite-Guraliuc, Helen M. E. Duyvesteyn, Muneeswaran Selvaraj, Alexander J. Mentzer, Raksha Das, Wanwisa Dejnirattisai, Nigel Temperton, Paul Klenerman, Susanna J. Dunachie, Elizabeth E. Fry, Juthathip Mongkolsapaya, Jingshan Ren, David I. Stuart, Gavin R. Screaton
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Under pressure from neutralising antibodies induced by vaccination or infection the SARS-CoV-2 spike gene has become a hotspot for evolutionary change, leading to the failure of all mAbs developed for clinical use. Most potent antibodies bin
Externí odkaz:
https://doaj.org/article/40347f991a6543e8a3b3edb8d9a26a4b
Autor:
Manon Ragonnet-Cronin, Rungtiwa Nutalai, Jiandong Huo, Aiste Dijokaite-Guraliuc, Raksha Das, Aekkachai Tuekprakhon, Piyada Supasa, Chang Liu, Muneeswaran Selvaraj, Natalie Groves, Hassan Hartman, Nicholas Ellaby, J. Mark Sutton, Mohammad W. Bahar, Daming Zhou, Elizabeth Fry, Jingshan Ren, Colin Brown, Paul Klenerman, Susanna J. Dunachie, Juthathip Mongkolsapaya, Susan Hopkins, Meera Chand, David I. Stuart, Gavin R. Screaton, Sakib Rokadiya
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract COVID-19 patients at risk of severe disease may be treated with neutralising monoclonal antibodies (mAbs). To minimise virus escape from neutralisation these are administered as combinations e.g. casirivimab+imdevimab or, for antibodies targ
Externí odkaz:
https://doaj.org/article/3441fa6cd88c4fceaa3ef6f2d837af24
Autor:
Aiste Dijokaite-Guraliuc, Raksha Das, Rungtiwa Nutalai, Daming Zhou, Alexander J. Mentzer, Chang Liu, Piyada Supasa, Susanna J. Dunachie, Teresa Lambe, Elizabeth E. Fry, Juthathip Mongkolsapaya, Jingshan Ren, Jiandong Huo, David I. Stuart, Gavin R. Screaton
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-4 (2022)
Externí odkaz:
https://doaj.org/article/1b7a077d33534094a9ea674643e6d97b
Autor:
Jiandong Huo, Aiste Dijokaite-Guraliuc, Rungtiwa Nutalai, Raksha Das, Daming Zhou, Alexander J. Mentzer, Elizabeth E. Fry, Juthathip Mongkolsapaya, Jingshan Ren, David I. Stuart, Gavin R. Screaton
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-4 (2022)
Externí odkaz:
https://doaj.org/article/39dc6318f89d4aadb7525858f714488e
Autor:
Aiste Dijokaite-Guraliuc, Raksha Das, Daming Zhou, Helen M. Ginn, Chang Liu, Helen M.E. Duyvesteyn, Jiandong Huo, Rungtiwa Nutalai, Piyada Supasa, Muneeswaran Selvaraj, Thushan I. de Silva, Megan Plowright, Thomas A.H. Newman, Hailey Hornsby, Alexander J. Mentzer, Donal Skelly, Thomas G. Ritter, Nigel Temperton, Paul Klenerman, Eleanor Barnes, Susanna J. Dunachie, Cornelius Roemer, Thomas P. Peacock, Neil G. Paterson, Mark A. Williams, David R. Hall, Elizabeth E. Fry, Juthathip Mongkolsapaya, Jingshan Ren, David I. Stuart, Gavin R. Screaton, Christopher Conlon, Alexandra Deeks, John Frater, Siobhan Gardiner, Anni Jämsén, Katie Jeffery, Tom Malone, Eloise Phillips, Barbara Kronsteiner-Dobramysl, Priyanka Abraham, Sagida Bibi, Teresa Lambe, Stephanie Longet, Tom Tipton, Miles Carrol, Lizzie Stafford
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112271- (2023)
Summary: In November 2021, Omicron BA.1, containing a raft of new spike mutations, emerged and quickly spread globally. Intense selection pressure to escape the antibody response produced by vaccines or severe acute respiratory syndrome coronavirus 2
Externí odkaz:
https://doaj.org/article/74b091e4af5241cd9320ea266b208fa6
Autor:
Kuan-Ying A. Huang, Daming Zhou, Elizabeth E. Fry, Abhay Kotecha, Peng-Nien Huang, Shu-Li Yang, Kuo-Chien Tsao, Yhu-Chering Huang, Tzou-Yien Lin, Jingshan Ren, David I. Stuart
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
To date, no therapeutic agents against enterovirus 71, the causative agent of hand, foot and mouth disease, exist. Here, using Cryo-EM Huang et al. characterize two plasmablast-derived plateau-binding neutralizing antibodies conferring effective prot
Externí odkaz:
https://doaj.org/article/4b4769b88b7b49b0ba87e9ad7d89cbcd
Autor:
Daming Zhou, Ling Qin, Helen M. E. Duyvesteyn, Yuguang Zhao, Tzou-Yien Lin, Elizabeth E. Fry, Jingshan Ren, Kuan-Ying A. Huang, David I. Stuart
Publikováno v:
Viruses, Vol 14, Iss 12, p 2625 (2022)
Echoviruses, for which there are currently no approved vaccines or drugs, are responsible for a range of human diseases, for example echovirus 11 (E11) is a major cause of serious neonatal morbidity and mortality. Decay-accelerating factor (DAF, also
Externí odkaz:
https://doaj.org/article/8ef0892035cc4e4ea0eb6467711beea1
Autor:
Yuguang Zhao, Daming Zhou, Tao Ni, Dimple Karia, Abhay Kotecha, Xiangxi Wang, Zihe Rao, E. Yvonne Jones, Elizabeth E. Fry, Jingshan Ren, David I. Stuart
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Here, the authors provide the structure of mature Coxsackie Virus A10 alone and in complex with its receptor KREMEN1, and of A-particles. This shows how the receptor spans the viral canyon and suggests that receptor binding triggers pocket factor rel
Externí odkaz:
https://doaj.org/article/be45168770654d1e8ea295697ed054b8
Autor:
Powell, Gareth T., Faro, Ana, Yuguang Zhao, Stickney, Heather, Novellasdemunt, Laura, Henriques, Pedro, Gestri, Gaia, White, Esther Redhouse, Jingshan Ren, Weixian Lu, Young, Rodrigo M., Hawkins, Thomas A., Cavodeassi, Florencia, Schwarz, Quenten, Dreosti, Elena, Raible, David W., Li, Vivian S. W., Wright, Gavin J., Jones, E. Yvonne, Wilson, Stephen W.
Publikováno v:
Science; 5/3/2024, Vol. 384 Issue 6695, p573-579, 7p, 5 Diagrams