Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Jingsen Meng"'
Autor:
Shanbo Yang, Chao Wang, Lingyu Shi, Jing Chang, Yujing Zhang, Jingsen Meng, Wenjing Liu, Jun Zeng, Renshuai Zhang, Yingchun Shao, Dongming Xing
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2755-2764 (2022)
A set of novel diarylpyridines as anti-tubulin agents were designed, synthesised using a rigid pyridine as a linker to fix the cis-orientation of ring-A and ring-B. All of the target compounds were evaluated for their in vitro antiproliferative activ
Externí odkaz:
https://doaj.org/article/54bb24125c124900bb988da63e194a86
Autor:
Chao Wang, Lingyu Shi, Shanbo Yang, Jing Chang, Wenjing Liu, Jun Zeng, Jingsen Meng, Renshuai Zhang, Dongming Xing
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
Cancer threatens human health and life. Therefore, it is particularly important to develop safe and effective antitumor drugs. Microtubules, the main component of cytoskeleton, play an important role in maintaining cell morphology, mitosis, and signa
Externí odkaz:
https://doaj.org/article/2462a0cc022647e5bca15fc0465da036
Autor:
Jing Chang, Chao Wang, Shanbo Yang, Lingyu Shi, Yujing Zhang, Wenjing Liu, Jingsen Meng, Jun Zeng, Renshuai Zhang, Ning Liu, Dongming Xing
Publikováno v:
Arabian Journal of Chemistry, Vol 15, Iss 11, Pp 104253- (2022)
A new series of novel diarylpyrazole derivatives as microtubule destabilizers were synthesized and evaluated for the anti-proliferative activities. Anti-proliferative assays were performed on the human cervix adenocarcinoma cell line (HeLa) and human
Externí odkaz:
https://doaj.org/article/e1ef45760e5b40bbb7092f5b6bf4f7e6
Autor:
Renshuai Zhang, Wenjing Liu, Jun Zeng, Jingsen Meng, Lingyu Shi, Shanbo Yang, Jing Chang, Chao Wang, Kunyue Xing, Jialian Wen, Ning Liu, Bing Liang, Dongming Xing
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 155, Iss , Pp 113732- (2022)
NPC1L1 is a crucial protein involved in sterol lipid absorption and has been shown to play an important role in intestinal cholesterol absorption. Hypercholesterolemia is a significant risk factor for cardiovascular diseases such as coronary heart di
Externí odkaz:
https://doaj.org/article/7f98d06683e9407385a214edbcfd1427
Autor:
Chao Wang, Jing Chang, Shanbo Yang, Lingyu Shi, Yujing Zhang, Wenjing Liu, Jingsen Meng, Jun Zeng, Renshuai Zhang, Dongming Xing
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Combretastatin A-4 (CA-4) is a potent inhibitor of tubulin polymerization and a colchicine binding site inhibitor (CBSI). The structure-activity relationship study of CA-4 showed that the cis double bond configuration and the 3,4,5-trimethoxy group o
Externí odkaz:
https://doaj.org/article/74d74a9c4195423ab25a00131036fd22
Autor:
Lingyu Shi, Shanbo Yang, Jing Chang, Yujing Zhang, Wenjing Liu, Jun Zeng, Jingsen Meng, Renshuai Zhang, Chao Wang, Dongming Xing
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
A series of new 9-aryl-5H-pyrido[4,3-b]indole derivatives as tubulin polymerization inhibitors were designed, synthesized, and evaluated for antitumor activity. All newly prepared compounds were tested for their anti-proliferative activity in vitro a
Externí odkaz:
https://doaj.org/article/75d388630e1849218b5b1c44a0951196
Autor:
Renshuai Zhang, Jun Zeng, Wenjing Liu, Jingsen Meng, Chao Wang, Lingyu Shi, Shanbo Yang, Jing Chang, Dongming Xing
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Lipid metabolism appears to play significant roles in the development of cancer. Numerous studies have shown that the evolution of malignancies, including breast, prostate, and colorectal cancers, involves cholesterol in a profound manner. A crucial
Externí odkaz:
https://doaj.org/article/586576063c904afb823f4d909bb15384
Autor:
Renshuai Zhang, Jingsen Meng, Shanbo Yang, Wenjing Liu, Lingyu Shi, Jun Zeng, Jing Chang, Bing Liang, Ning Liu, Dongming Xing
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The hypoxic state of the tumor microenvironment leads to reprogramming lipid metabolism in tumor cells. Adipose triglyceride lipase, also known as patatin-like phospholipase= domain-containing protein 2 and Adipose triglyceride lipase (ATGL), as an e
Externí odkaz:
https://doaj.org/article/02ce8306955741efbca0085d69854ec8
Autor:
Jun Zeng, Wenjing Liu, Bing Liang, Lingyu Shi, Shanbo Yang, Jingsen Meng, Jing Chang, Xiaokun Hu, Renshuai Zhang, Dongming Xing
Publikováno v:
Molecules, Vol 27, Iss 21, p 7494 (2022)
Isoliquiritigenin (ISL) is a flavonoid with a chalcone structure extracted from the natural herb Glycyrrhiza glabra. Its anti-inflammatory, antibacterial, antioxidant, and anticancer activities have been extensively studied. Moreover, ISL also posses
Externí odkaz:
https://doaj.org/article/e87291afba0142139dc525903e1fbb5d
Autor:
Wenjing Liu, Bing Liang, Jun Zeng, Jingsen Meng, Lingyu Shi, Shanbo Yang, Jing Chang, Chao Wang, Xiaokun Hu, Xufu Wang, Na Han, Chenghui Lu, Jiao Li, Congcong Wang, Huanting Li, Renshuai Zhang, Dongming Xing
Publikováno v:
Molecules, Vol 27, Iss 19, p 6270 (2022)
Elevated cholesterol significantly increases the risk of developing atherosclerosis and coronary heart disease. The key to treating hypercholesterolemia is lowering plasma cholesterol levels. There have been no studies on the cholesterol-lowering pot
Externí odkaz:
https://doaj.org/article/1163143b094a49c09952099acff44652