Data from An Orally Available Small-Molecule Inhibitor of c-Met, PF-2341066, Exhibits Cytoreductive Antitumor Efficacy through Antiproliferative and Antiangiogenic Mechanisms

Autor: James G. Christensen, Barbara Mroczkowski, Steven L. Bender, Gerrit Los, Mitchell D. Nambu, Pei-Pei Kung, Jingrong J. Cui, Gordon Alton, Tatiana B. Koudriakova, Shinji Yamazaki, Scott R. McDonnell, Maria E. Arango, Joseph H. Lee, Qiuhua Li, Helen Y. Zou

The c-Met receptor tyrosine kinase and its ligand, hepatocyte growth factor (HGF), have been implicated in the progression of several human cancers and are attractive therapeutic targets. PF-2341066 was identified as a potent, orally bioavailable, AT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d31a60f19801955af72b091c38b58ad
https://doi.org/10.1158/0008-5472.c.6496341

Corrigendum: Proteasome inhibitor YSY01A abrogates constitutive STAT3 signaling via down-regulation of Gp130 and JAK2 in human A549 lung cancer cells.

Autor: Huang W; Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China.; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China., Yuan X; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China., Sun T; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China., Fan S; Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China., Wang J; Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China., Zhou Q; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China., Guo W; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China., Ran F; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China., Ge Z; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Peking University, Beijing, China., Yang H; Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Li R; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Peking University, Beijing, China., Cui J; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2024 Aug 05; Vol. 15, pp. 1418274. Date of Electronic Publication: 2024 Aug 05 (Print Publication: 2024).

Synthesis and biological evaluation of curcumin derivatives modified with α-amino boronic acid as proteasome inhibitors.

Autor: Zhang W; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, PR China., Bai H; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, PR China., Han L; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, PR China., Zhang H; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, PR China., Xu B; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, PR China., Cui J; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, PR China., Wang X; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, PR China., Ge Z; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, PR China., Li R; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, PR China. Electronic address: lirt@bjmu.edu.cn.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2018 Aug 01; Vol. 28 (14), pp. 2459-2464. Date of Electronic Publication: 2018 Jun 02.

Proteasome Inhibitor YSY01A Abrogates Constitutive STAT3 Signaling via Down-regulation of Gp130 and JAK2 in Human A549 Lung Cancer Cells.

Autor: Huang W; Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical CollegeBeijing, China.; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking UniversityBeijing, China., Yuan X; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking UniversityBeijing, China., Sun T; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking UniversityBeijing, China., Fan S; Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical CollegeBeijing, China., Wang J; Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical CollegeBeijing, China., Zhou Q; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking UniversityBeijing, China., Guo W; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking UniversityBeijing, China., Ran F; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking UniversityBeijing, China., Ge Z; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Peking UniversityBeijing, China., Yang H; Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing, China., Li R; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Peking UniversityBeijing, China., Cui J; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking UniversityBeijing, China.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2017 Aug 24; Vol. 8, pp. 476. Date of Electronic Publication: 2017 Aug 24 (Print Publication: 2017).

Diasteltoxins A-C, Asteltoxin-Based Dimers from a Mutant of the Sponge-Associated Emericella variecolor Fungus.

Autor: Long H; State Key Laboratory of Natural and Biomimetic Drugs, Peking University , Beijing 100191, P. R. China., Cheng Z; State Key Laboratory of Natural and Biomimetic Drugs, Peking University , Beijing 100191, P. R. China., Huang W; State Key Laboratory of Natural and Biomimetic Drugs, Peking University , Beijing 100191, P. R. China., Wu Q; State Key Laboratory of Natural and Biomimetic Drugs, Peking University , Beijing 100191, P. R. China., Li X; State Key Laboratory of Natural and Biomimetic Drugs, Peking University , Beijing 100191, P. R. China., Cui J; State Key Laboratory of Natural and Biomimetic Drugs, Peking University , Beijing 100191, P. R. China., Proksch P; Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University , 40225 Duesseldorf, Germany., Lin W; State Key Laboratory of Natural and Biomimetic Drugs, Peking University , Beijing 100191, P. R. China.

Publikováno v: Organic letters [Org Lett] 2016 Sep 16; Vol. 18 (18), pp. 4678-81. Date of Electronic Publication: 2016 Aug 29.