Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Jingrong Cao"'
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
As an opportunistic phytopathogen, Sarocladium strictum has only been shown to cause neurological disease in immunocompromised patients, where antifungal therapy was not effective. We report a case of Sarocladium strictum meningoencephalitis in an ap
Externí odkaz:
https://doaj.org/article/eb1df236cb1e4d7ea9c4a40e02ca16ff
Publikováno v:
Journal of Medical Biochemistry. 42:258-264
Background: This study aims to establish reference intervals (RIs) for thyroid hormones in the elderly population and analyze their influence on the prevalence of subclinical hypothyroidism. Methods: Thyroid hormone records of subjects who underwent
Autor:
Simon Giroux, Jon H. Come, Robert J. Davies, Upul K. Bandarage, Alex Aronov, David Messersmith, Cameron Stuver Moody, Swett Rebecca Jane, Sudipta Mahajan, Kevin M. Cottrell, Jingrong Cao, Marc Jacobs, Jinwang Xu
Publikováno v:
ACS Med Chem Lett
[Image: see text] Phosphoinositide 3-kinases (PI3Ks) are a family of enzymes that control a wide variety of cellular functions such as cell growth, proliferation, differentiation, motility, survival, and intracellular trafficking. PI3Kγ plays a crit
Background: Infection, even outbreak, caused by Cryptococcus gattii (C. gattii ) has been reported in Canada and the United States, but there were sparsely-reported cases of C. gattii in China. Our interest in occurrence, clinical manifestation, labo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da818edf18f6edbb26708b13ac18917e
https://doi.org/10.21203/rs.2.21273/v1
https://doi.org/10.21203/rs.2.21273/v1
Autor:
Jeremy Green, Upul K. Bandarage, Craig Marhefka, Suganthi Nanthakumar, Jon H. Come, Huai Gao, Jingrong Cao, Marc Jacobs, John J. Court
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:2622-2626
Rho kinase (ROCK) inhibitors are potential therapeutic agents for the treatment of a variety of disorders including hypertension, glaucoma and erectile dysfunction. Here we disclose a series of potent and selective ROCK inhibitors based on a substitu
Publikováno v:
Experimental and Therapeutic Medicine
The present study prepared 2 types of DNA diagnostic chips based on 16S ribosomal DNA (rDNA) and 18S-28S rDNA, and evaluated their values in the detection of pathogens in intracranial bacterial/fungal infections. A total of 14 probes of bacteria (Kle
Autor:
Jianglin Liang, Robert J. Davies, James P. Griffith, Hardwin O'dowd, Cameron Stuver Moody, Elaine Krueger, Philip N. Collier, Yusheng Liao, Upul K. Bandarage, Alex Aronov, Jian Wang, Jingrong Cao, Derek B. Lowe, Veronique Damagnez, Elaine Y. Chin, John D. Doran, Emmanuelle Sizensky, Wojciech Dworakowski, Sudipta Mahajan, David D. Deininger, Marc Jacobs, Jinwang Xu, Arnaud Le Tiran, Suvarna Khare-Pandit, Albert C. Pierce, Suganthi Nanthakumar, Ron Grey, David Messersmith, James A. Henderson, Jon H. Come
Publikováno v:
Journal of Medicinal Chemistry. 61:5245-5256
The lipid kinase phosphoinositide 3-kinase γ (PI3Kγ) has attracted attention as a potential target to treat a variety of autoimmune disorders, including multiple sclerosis, due to its role in immune modulation and microglial activation. By minimizi
Autor:
Boyd, Michael J., Collier, Philip N., Clark, Michael P., Hongbo Deng, Kesavan, Sarathy, Ronkin, Steven M., Waal, Nathan, Jian Wang, Jingrong Cao, Pan Li, Jon Come, Davies, Ioana, Duffy, John P., Cochran, John E., Court, John J., Chandupatla, Kishan, Jackson, Katrina L., Maltais, Francois, O'Dowd, Hardwin, Boucher, Christina
Publikováno v:
Journal of Medicinal Chemistry; 12/23/2021, Vol. 64 Issue 24, p17777-17794, 18p
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(15)
Solubilizing groups have been frequently appended to kinase inhibitor drug molecules when solubility is insufficient for pharmaceutical development. Such groups are usually located at substitution sites that have minimal impact on target activity. In
Autor:
Nigel Ewing, Judy Straub, Ursula A. Germann, James W. Janetka, Alex Aronov, Ernst ter Haar, Jeremy Green, Mark N. Namchuk, Guy W. Bemis, Xiaoling Xie, William Markland, Michael R. Hale, Pamella J. Ford, Gabriel Martinez-Botella, Guanjing Chen, Qing Tang, Francois Maltais, Marc Jacobs, Jingrong Cao, Srinivasu Poondru, Suganthini Nanthakumar
Publikováno v:
Journal of Medicinal Chemistry. 52:6362-6368
The Ras/Raf/MEK/ERK signal transduction, an oncogenic pathway implicated in a variety of human cancers, is a key target in anticancer drug design. A novel series of pyrimidylpyrrole ERK inhibitors has been identified. Discovery of a conformational ch