Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jingmin Guan"'
Publikováno v:
PLoS Genetics, Vol 17, Iss 8, p e1009718 (2021)
Insects depend on the innate immune response for defense against a wide array of pathogens. Central to Drosophila immunity are antimicrobial peptides (AMPs), released into circulation when pathogens trigger either of the two widely studied signal pat
Externí odkaz:
https://doaj.org/article/b077b047fbe34e54a9abe3d1ffed193d
Autor:
Qiuyun Xu, Anrui Lu, Guohua Xiao, Bing Yang, Jie Zhang, Xuquan Li, Jingmin Guan, Qimiao Shao, Brenda T Beerntsen, Peng Zhang, Chengshu Wang, Erjun Ling
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43769 (2012)
BACKGROUND: Lepidoptera insects have a novel development process comprising several metamorphic stages during their life cycle compared with vertebrate animals. Unlike most Lepidoptera insects that live on nectar during the adult stage, the Bombyx mo
Externí odkaz:
https://doaj.org/article/2f98db18a7514aa6842f5ef46e8122af
Autor:
Enen Guo, Qianyu He, Shumin Liu, Ling Tian, Zhentao Sheng, Qin Peng, Jingmin Guan, Mingan Shi, Kang Li, Lawrence I Gilbert, Jian Wang, Yang Cao, Sheng Li
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e53256 (2012)
Little is known about how the putative juvenile hormone (JH) receptor, the bHLH-PAS transcription factor MET, is involved in 20-hydroxyecdysone (20E; the molting hormone) action. Here we report that two MET proteins found in the silkworm, Bombyx mori
Externí odkaz:
https://doaj.org/article/7182da4396674636abad3c46a2562f60
Autor:
Yun Zhao, Huixiong Xu, Min Chen, Chun Hou, Wenjia Wang, Pingping Nie, Shi Jiao, Liwei An, Zhaocai Zhou, Hui Zhang, Yang Tang, Zhifa Cao, Jingmin Guan
Publikováno v:
The Journal of Experimental Medicine
An et al. identify a novel MST4-mediated YAP inactivation signaling pathway and demonstrate that the MST4–YAP axis is required to suppress gastric tumorigenesis in vivo.
Hyperactivation of YAP has been commonly associated with tumorigenesis, a
Hyperactivation of YAP has been commonly associated with tumorigenesis, a
Autor:
Jian Ma, Qi Xu, Shi Jiao, Zhubing Shi, Min Chen, Jingmin Guan, Ziyang Gao, Xiaoman Zhang, Zhaocai Zhou, Yunfeng Cheng, Yehua Li, Hui Zhang, Li Zhou
Publikováno v:
Journal of Biological Chemistry. 293:14455-14469
The mammalian STE20-like protein kinase 1 (MST1)-MOB kinase activator 1 (MOB1) complex has been shown to suppress the oncogenic activity of Yes-associated protein (YAP) in the mammalian Hippo pathway, which is involved in the development of multiple
Autor:
Chuanchuan Li, Yunfeng Cheng, Yugong Wang, Wenjia Wang, Shi Jiao, Zhaocai Zhou, Min Chen, Jingmin Guan
Publikováno v:
The Journal of Experimental Medicine
Jiao et al. show that the key player of antiviral immunity IRF3 binds to and promotes the transactivation of the YAP–TEAD4 complex to coregulate transcription of Hippo pathway target genes and that therapeutic targeting of IRF3 suppresses YAP-drive
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 17, Iss 8, p e1009718 (2021)
PLoS Genetics, Vol 17, Iss 8, p e1009718 (2021)
Insects depend on the innate immune response for defense against a wide array of pathogens. Central to Drosophila immunity are antimicrobial peptides (AMPs), released into circulation when pathogens trigger either of the two widely studied signal pat
Autor:
Zhaocai Zhou, Yehua Li, Wenjia Wang, Shi Jiao, Jingmin Guan, Chun Hou, Jian Ma, Yunfeng Cheng, Li Zhou
Toll-like receptors (TLRs) are key players of the innate immune system and contribute to inflammation and pathogen clearance. Although TLRs have been extensively studied, it remains unclear how exactly bacterial lipopolysaccharide (LPS)-induced confo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a62d9ab9663b926e661fe8bea0afe2
https://europepmc.org/articles/PMC6393614/
https://europepmc.org/articles/PMC6393614/
Autor:
Lulu Kong, Nalini Ramarao, Kenneth Söderhäll, Jingmin Guan, Bing Yang, Erjun Ling, Muwang Li, Julián F. Hillyer, Anrui Lu, Chao-Liang Liu
Publikováno v:
Archives of Insect Biochemistry and Physiology. 88:64-84
Thermolysin, a metallopeptidase secreted by pathogenic microbes, is concluded as an important virulence factor due to cleaving purified host proteins in vitro. Using the silkworm Bombyx mori as a model system, we found that thermolysin injection into
Publikováno v:
Archives of Insect Biochemistry and Physiology. 97:e21441
Signal peptidase complexes (SPCs) are conserved from bacteria to human beings, and are typically composed of four to five subunits. There are four genes encoding SPC proteins in the red flour beetle, Tribolium castaneum. To understand their importanc