Zobrazeno 1 - 10 of 75 pro vyhledávání: '"Jingling Jin"'
1
Akademický článek
TIGIT is the central player in T-cell suppression associated with CAR T-cell relapse in mantle cell lymphoma
Autor: Vivian Changying Jiang, Dapeng Hao, Preetesh Jain, Yijing Li, Qingsong Cai, Yixin Yao, Lei Nie, Yang Liu, Jingling Jin, Wei Wang, Heng-Huan Lee, Yuxuan Che, Enyu Dai, Guangchun Han, Ruiping Wang, Kunal Rai, Andrew Futreal, Christopher Flowers, Linghua Wang, Michael Wang
Publikováno v: Molecular Cancer, Vol 21, Iss 1, Pp 1-16 (2022)
Abstract Background Chimeric antigen receptor (CAR) T-cell therapy using brexucabtagene autoleucel (BA) induces remission in many patients with mantle cell lymphoma (MCL), and BA is the only CAR T-cell therapy approved by the FDA for MCL. However, de
Externí odkaz: https://doaj.org/article/aefec36a3cd54b8a9646daef0e07986d
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2
Akademický článek
Electroacupuncture ameliorates inflammatory response induced by retinal ischemia-reperfusion injury and protects the retina through the DOR-BDNF/Trkb pathway
Autor: Runjie Guo, Yongjie Zhang, Yue Geng, Ping Chen, Tiantian Fu, Yong Xia, Ren Zhang, Yuan Zhu, Jingling Jin, Nange Jin, Hong Xu, Xuesong Tian
Publikováno v: Frontiers in Neuroanatomy, Vol 16 (2023)
Objectives: Retinal ischemia-reperfusion injury (RIRI) is the common pathological basis of many ophthalmic diseases in the later stages, and inflammation is the primary damage mechanism of RIRI. Our study aimed to assess whether electroacupuncture (E
Externí odkaz: https://doaj.org/article/30d62917ef9c4fb2b893c051d6afe990
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4
Akademický článek
A Novel Cell Line Based Orthotopic Xenograft Mouse Model That Recapitulates Human Hepatoblastoma
Autor: Sarah E. Woodfield, Yan Shi, Roma H. Patel, Jingling Jin, Angela Major, Stephen F. Sarabia, Zbigniew Starosolski, Barry Zorman, Siddharth S. Gupta, Zhenghu Chen, Aryana M. Ibarra, Karl-Dimiter Bissig, Ketan B. Ghaghada, Pavel Sumazin, Dolores López-Terrada, Sanjeev A. Vasudevan
Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Currently, preclinical testing of therapies for hepatoblastoma (HB) is limited to subcutaneous and intrasplenic xenograft models that do not recapitulate the hepatic tumors seen in patients. We hypothesized that injection of HB cell lines in
Externí odkaz: https://doaj.org/article/6656677b34c24573aea30e99a87fadd7
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5
Akademický článek
Activation of CDK4 Triggers Development of Non-alcoholic Fatty Liver Disease
Autor: Jingling Jin, Leila Valanejad, Thuy Phuong Nguyen, Kyle Lewis, Mary Wright, Ashley Cast, Lauren Stock, Lubov Timchenko, Nikolai A. Timchenko
Publikováno v: Cell Reports, Vol 16, Iss 3, Pp 744-756 (2016)
The development of non-alcoholic fatty liver disease (NAFLD) is a multiple step process. Here, we show that activation of cdk4 triggers the development of NAFLD. We found that cdk4 protein levels are elevated in mouse models of NAFLD and in patients
Externí odkaz: https://doaj.org/article/51c0cbc6517543409a69138d989bab72
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6
Akademický článek
Increased Expression of Enzymes of Triglyceride Synthesis Is Essential for the Development of Hepatic Steatosis
Autor: Jingling Jin, Polina Iakova, Meghan Breaux, Emily Sullivan, Nicole Jawanmardi, Dahu Chen, Yanjun Jiang, Estela M. Medrano, Nikolai A. Timchenko
Publikováno v: Cell Reports, Vol 3, Iss 3, Pp 831-843 (2013)
Molecular mechanisms underpinning nonalcoholic fatty liver disease (NAFLD) are not well understood. The earliest step of NAFLD is hepatic steatosis, which is one of the main characteristics of aging liver. Here, we present a molecular scenario of age
Externí odkaz: https://doaj.org/article/fc931c03c8ea436ba9a13733e7141736
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