Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jingli A. Zhang"'
Autor:
Guanyi Huang, Anjali Bisaria, Devin L. Wakefield, Tracy M. Yamawaki, Xin Luo, Jingli A. Zhang, Patrick Vigneault, Jinghong Wang, Jeffrey D. Reagan, Oliver Oliverio, Hong Zhou, Chi-Ming Li, Olaia F. Vila, Songli Wang, Fady I. Malik, James J. Hartman, Christopher M. Hale
Publikováno v:
Stem Cell Reports, Vol 18, Iss 1, Pp 220-236 (2023)
Summary: Titin-truncating variants (TTNtv) are the single largest genetic cause of dilated cardiomyopathy (DCM). In this study we modeled disease phenotypes of A-band TTNtv-induced DCM in human induced pluripotent stem cell-derived cardiomyocytes (hi
Externí odkaz:
https://doaj.org/article/30e3b255f0a347979433bbc120f0b28e
Autor:
Koorosh J. Elihu, Long Li, Robert R. Butler, Jingli A. Zhang, Ameya Champhekar, Deirdre D. Scripture-Adams, Ellen V. Rothenberg, Alexandra M. Arias, Sagar S. Damle, Shuyang Qin
Publikováno v:
The Journal of Immunology. 193:3470-3491
GATA-3 expression is crucial for T cell development and peaks during commitment to the T cell lineage, midway through the CD4−CD8− (double-negative [DN]) stages 1–3. We used RNA interference and conditional deletion to reduce GATA-3 protein acu
Autor:
Ali Mortazavi, Jingli A. Zhang, Camden Jansen, Weihua Zeng, Pentao Liu, Maile Romero-Wolf, Long Li, William J.R. Longabaugh, Hiroyuki Hosokawa, Ellen V. Rothenberg, Hao Yuan Kueh
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(23)
T-cell development from hematopoietic progenitors depends on multiple transcription factors, mobilized and modulated by intrathymic Notch signaling. Key aspects of T-cell specification network architecture have been illuminated through recent reports
Autor:
Marei Dose, Hao Yuan Kueh, Long Li, Ellen V. Rothenberg, Fotini Gounari, Ruzbeh Mosadeghi, Jingli A. Zhang
Publikováno v:
Blood. 122:902-911
Bcl11b is a T-cell specific gene in hematopoiesis that begins expression during T-lineage commitment and is required for this process. Aberrant expression of BCL11B or proto-oncogene translocation to the vicinity of BCL11B can be a contributing facto
Autor:
Mary A. Yui, Sagar S. Damle, Michael B. Elowitz, Kenneth K.H. Ng, George Freedman, Ellen V. Rothenberg, Jingli A. Zhang, Irwin D. Bernstein, Sharmayne Siu, Hao Yuan Kueh, Shirley Pease
During T cell development, multipotent progenitors relinquish competence for other fates and commit to the T cell lineage by turning on Bcl11b, which encodes a transcription factor. To clarify lineage commitment mechanisms, we followed developing T c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6afa36afc31ecf0099283cc18919e43e
https://resolver.caltech.edu/CaltechAUTHORS:20160613-162442836
https://resolver.caltech.edu/CaltechAUTHORS:20160613-162442836
Publikováno v:
Immunological reviews. 271(1)
The pathway to generate T cells from hematopoietic stem cells guides progenitors through a succession of fate choices while balancing differentiation progression against proliferation, stage to stage. Many elements of the regulatory system that contr
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 190(7)
NOD mice exhibit major defects in the earliest stages of T cell development in the thymus. Genome-wide genetic and transcriptome analyses were used to investigate the origins and consequences of an early T cell developmental checkpoint breakthrough i
SummaryT cell development comprises a stepwise process of commitment from a multipotent precursor. To define molecular mechanisms controlling this progression, we probed five stages spanning the commitment process using RNA-seq and ChIP-seq to track
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f078bfcf10994f14b339f0f128ee720
https://resolver.caltech.edu/CaltechAUTHORS:20120511-113721604
https://resolver.caltech.edu/CaltechAUTHORS:20120511-113721604
Autor:
Ellen V. Rothenberg, Jingli A. Zhang
Publikováno v:
Current Topics in Microbiology and Immunology ISBN: 9783642241024
T-cell development endows cells with a flexible range of effector differentiation options, superimposed on a stable core of lineage-specific gene expression that is maintained while access to alternative hematopoietic lineages is permanently renounce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9f7c0ed43ed4bcfec76b2cad820779
https://doi.org/10.1007/82_2011_168
https://doi.org/10.1007/82_2011_168
Autor:
Longabaugh, William J. R., Weihua Zeng, Jingli A. Zhang, Hiroyuki Hosokawa, Jansen, Camden S., Long Li, Romero-Wolf, Maile, Pentao Liu, Hao Yuan Kueh, Mortazavi, Ali, Rothenberg, Ellen V.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 6/6/2017, Vol. 114 Issue 23, p5800-5807, 8p