Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Jinglei Cheng"'
Autor:
Norihiro Imai, Yuki Ohsaki, Jinglei Cheng, Jingjing Zhang, Fumitaka Mizuno, Taku Tanaka, Shinya Yokoyama, Kenta Yamamoto, Takanori Ito, Yoji Ishizu, Takashi Honda, Masatoshi Ishigami, Hiroaki Wake, Hiroki Kawashima
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Lipid droplets (LDs) have been observed in the nuclei of hepatocytes; however, their significance in liver disease remains unresolved. Our purpose was to explore the pathophysiological features of intranuclear LDs in liver diseases. We inclu
Externí odkaz:
https://doaj.org/article/cbcdd40a7e6244acaa3c352ebdd6a8e6
Autor:
Yuta Ogasawara, Jinglei Cheng, Tsuyako Tatematsu, Misaki Uchida, Omi Murase, Shogo Yoshikawa, Yuki Ohsaki, Toyoshi Fujimoto
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
The source of phospholipids to generate autophagosomal membranes, particularly after prolonged starvation, is not well characterized. Here, the authors show that CCTβ3, the rate limiting enzyme in phosphatidylcholine synthesis, is activated on lipid
Externí odkaz:
https://doaj.org/article/01aa050b4596409a8597336a1d223531
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
The origin and physiological significance of lipid droplets (LDs) in the nucleus is not clear. Here authors show that nucleoplasmic LDs in hepatocytes are derived from apolipoprotein B (ApoB)-free lumenal LDs and constitute a feedback mechanism to re
Externí odkaz:
https://doaj.org/article/98f83579d492448e8f406580e20eef6d
Autor:
Tomoya Yamaguchi, Can Lu, Lisa Ida, Kiyoshi Yanagisawa, Jiro Usukura, Jinglei Cheng, Naoe Hotta, Yukako Shimada, Hisanori Isomura, Motoshi Suzuki, Toyoshi Fujimoto, Takashi Takahashi
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Resistance to receptor tyrosine kinase inhibitors is a major obstacle in treatment of lung adenocarcinoma. Yamaguchi et al.identify the orphan receptor ROR1 as a potential target to overcome this resistance, by virtue of its role in promoting cell su
Externí odkaz:
https://doaj.org/article/7c75a87e81e0429b80dd4b3a91b33ba8
Autor:
Takuma Tsuji, Megumi Fujimoto, Tsuyako Tatematsu, Jinglei Cheng, Minami Orii, Sho Takatori, Toyoshi Fujimoto
Publikováno v:
eLife, Vol 6 (2017)
Niemann-Pick type C is a storage disease caused by dysfunction of NPC proteins, which transport cholesterol from the lumen of lysosomes to the limiting membrane of that compartment. Using freeze fracture electron microscopy, we show here that the yea
Externí odkaz:
https://doaj.org/article/5b8ac16b97684bf7a268e3dd85ae1c07
Autor:
Keyu Ning, Houfang Liu, Zhenyi Ju, Chi Fang, Caihua Wan, Jinglei Cheng, Xiao Liu, Linsen Li, Jiafeng Feng, Hongxiang Wei, Xiufeng Han, Yi Yang, Tian-Ling Ren
Publikováno v:
AIP Advances, Vol 7, Iss 1, Pp 015035-015035-5 (2017)
As one invigorated filed of spin caloritronics combining with spin, charge and heat current, the magneto-Seebeck effect has been experimentally and theoretically studied in spin tunneling thin films and nanostructures. Here we analyze the tunnel magn
Externí odkaz:
https://doaj.org/article/9a2253d07ebd455c8a5573a6f83893dc
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
The original version of this Article contained errors in the Abstract and Introduction, whereby CCTα was incorrectly defined as an abbreviation of CDP-choline diacylglycerol phosphotransferase α, instead of CTP:phosphocholine cytidylyltransferase
Externí odkaz:
https://doaj.org/article/f37b9e5ddd804b0aba5c33bd03103a55
Autor:
Michitaka Suzuki, Yuki Ohsaki, Tsuyako Tatematsu, Yuki Shinohara, Takashi Maeda, Jinglei Cheng, Toyoshi Fujimoto
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42379 (2012)
Lipid droplets (LDs) in non-adipocytes contain triglycerides (TG) and cholesterol esters (CE) in variable ratios. TG-rich LDs are generated when unsaturated fatty acids are administered, but the conditions that induce CE-rich LD formation are less we
Externí odkaz:
https://doaj.org/article/dbb4a9b77a0142e38b138a29cdeeab4b
Autor:
Norihiro Imai, Yuki Ohsaki, Jinglei Cheng, Jingjing Zhang, Fumitaka Mizuno, Taku Tanaka, Shinya Yokoyama, Kenta Yamamoto, Takanori Ito, Yoji Ishizu, Takashi Honda, Masatoshi Ishigami, Hiroaki Wake, Hiroki Kawashima
Aim Lipid droplets have been found in the nuclei of hepatocytes, however, their role in liver is not clearly understood. The purpose of this study was to explore the pathophysiological roles of intranuclear lipid droplets in liver diseases. Method Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc3d7464265ed99e7fbf65f4ba642d62
https://doi.org/10.21203/rs.3.rs-2225078/v1
https://doi.org/10.21203/rs.3.rs-2225078/v1
Autor:
Toyoshi Fujimoto, Yuki Ohsaki, Shogo Yoshikawa, Misaki Uchida, Jinglei Cheng, Omi Murase, Yuta Ogasawara, Tsuyako Tatematsu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Macroautophagy initiates by formation of isolation membranes, but the source of phospholipids for the membrane biogenesis remains elusive. Here, we show that autophagic membranes incorporate newly synthesized phosphatidylcholine, and that CTP:phospho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a9f2f30cc0a82a38bb17c4670c11190
https://doaj.org/article/01aa050b4596409a8597336a1d223531
https://doaj.org/article/01aa050b4596409a8597336a1d223531