Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Jingkao Chen"'
Publikováno v:
Investigational New Drugs. 38:755-764
Glioblastoma multiforme (GBM) is the most common malignant tumor of the central nervous system (CNS). Effective treatments remain limited. Therefore, novel chemotherapy drugs with high efficiency and few adverse effects are urgently needed. Histone d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c47d15bf6f8adb86ed7a79c665cc92cb
https://doi.org/10.1007/s10637-019-00821-4
https://doi.org/10.1007/s10637-019-00821-4
Autor:
Shengnan Wang, Qiuhe Chen, Jin-wu Yan, Wang Yan, Jingkao Chen, Yalin Tu, Ying Wang, Pi Rongbiao, Xiao Zhang, Xiaohong Yang
Publikováno v:
Medicinal Chemistry Research. 27:777-784
A novel multifunctional carbazole–aminoquinoline dimer PZ001 was designed, synthesized, and evaluated. The results indicated that PZ001 possessed selective copper chelation, and inhibited copper-induced Aβ1–42 aggregation. Furthermore, PZ001 exe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fb191e4fe25f54d0262a0dce482cb85
https://doi.org/10.1007/s00044-017-2101-9
https://doi.org/10.1007/s00044-017-2101-9
Publikováno v:
European Journal of Pharmacology. 899:173908
Rhein is one of the anthraquinones components of Rheum. It shows excellent clinical efficacy and is widely used in the management of several disease conditions including tumors, inflammation, diabetic nephropathy, and viral infections. In this review
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1261a35398289145f658fa0a761f084f
https://doi.org/10.1016/j.ejphar.2021.173908
https://doi.org/10.1016/j.ejphar.2021.173908
Autor:
Jiayu Gu, Huawei Sun, Bingzheng Lu, Jialuo Mai, Xiaofang Lu, Jun Lin, Guangmei Yan, Ying Ouyang, Yunling Dou, Wenbo Zhu, Fan Xing, Tiandong Leng, Xiaoke Zheng, Jingkao Chen
Publikováno v:
Tumor Biology. 37:14721-14731
The melastatin-like transient receptor potential 7 (TRPM7) has been implicated in proliferation or apoptosis of some cancers, indicating the potential of TRPM7 as an anti-anaplastic target. Here, we identified the characteristic TRPM7 channel current
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb2eae8ec96ee910c9d9c841922ca619
https://doi.org/10.1007/s13277-016-5317-2
https://doi.org/10.1007/s13277-016-5317-2
Autor:
Shijun Wen, Rongbiao Pi, Xiaohong Yang, Mingtao Li, Karl Wah Keung Tsim, Shanshan Ma, Yalin Tu, Yifan Han, Shengnan Wang, Chen Chen, Junfeng Lu, Qiuhe Chen, Jingkao Chen, Shinghung Mak
Publikováno v:
European Journal of Pharmacology. 883:173361
Alzheimer's disease (AD), which is characterized by impairment of cognitive functions, is a chronic neurodegenerative disease that mainly affects the elderly. Currently available anti-AD drugs can only offer limited symptom-relieving effects. “One-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b10d23c82dc93f25405170405cbf6e45
https://doi.org/10.1016/j.ejphar.2020.173361
https://doi.org/10.1016/j.ejphar.2020.173361
Autor:
Yiming Jiang, Jingkao Chen, Rongbiao Pi, Jin-wu Yan, Weibin Cai, Minghua Jin, Peiqing Liu, Meicun Yao
Publikováno v:
European Journal of Pharmacology. 868:172871
Niacin has been widely used as an antihyperlipidemic drug, but the flushing effect restricted its clinical application. Here, we developed novel niacin-lipoic acid dimers which lead to better lipid modulation, higher synergistic effects and less side
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e00a77c485a9014c543691b5596e6d31
https://doi.org/10.1016/j.ejphar.2019.172871
https://doi.org/10.1016/j.ejphar.2019.172871
Autor:
Jingkao Chen, Wei Kang, Alfred S. L. Cheng, Myth T.S. Mok, K. F. To, Anthony W.H. Chan, Francis K.L. Chan, Enders K.W. Ng, Huating Wang, Michael W.Y. Chan, Joseph J.Y. Sung, W Yang, J-L Chou, M S M Li, Jun Yu
Publikováno v:
Oncogene. 35:2133-2144
Accumulating evidence reveals the effectiveness of epigenetic therapy in gastric cancer. However, the molecular mechanisms and targets underlying such therapeutic responses remain elusive. Herein, we report an aberrant yet therapeutically rectifiable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::967f8c07af884933c9fdb9452962f670
https://doi.org/10.1038/onc.2015.276
https://doi.org/10.1038/onc.2015.276
Autor:
Qingyu Liu, Kaishu Li, Ming-Liang He, Rongbiao Pi, Ying Ouyang, Anmin Liu, Ming Luo, Yalin Tu, Jingkao Chen
Glioblastoma multiforme (GBM) is the most malignant type of primary brain tumor in adults and can diffusely infiltrate adjacent normal tissue. GBM is therefore rarely cured by surgery or radiation therapy. Matrix metalloproteinases (MMPs) are involve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4111543c63a058bc541935d1d453b9e
https://europepmc.org/articles/PMC5403421/
https://europepmc.org/articles/PMC5403421/
Autor:
Le Hang Lin, Fengyan Yu, Y. Jiao, Erwei Song, Jingkao Chen, Herui Yao, W. Tang, Qiang Liu, Dong Yin, X. Cui
Publikováno v:
Oncogene. 33:2629-2638
Recent studies suggested that cancer stem cells (CSCs) are capable of differentiating into endothelial cells and tumor endothelium may be derived from CSCs. But the mechanism remains unclear. We showed that vascular endothelial growth factor (VEGF) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f11b395ce884569bae838d226dcaee18
https://doi.org/10.1038/onc.2013.214
https://doi.org/10.1038/onc.2013.214
Autor:
Maria Digiacomo, Jingkao Chen, Xiaohong Yang, Shengnan Wang, Simona Sestito, Yifan Han, Giulia Nesi, Marco Macchia, Qiuhe Chen, Rongbiao Pi, Jiaqi Chu, Qiong Gu, Ziwei Chen, Simona Rapposelli, Yalin Tu
A series of rivastigmine-caffeic acid and rivastigmine-ferulic acid hybrids were designed, synthesized, and evaluated as multifunctional agents for Alzheimer's disease (AD) in vitro. The new compounds exerted antioxidant neuroprotective properties an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dfa5b64539e460c76a8b80706f03100
http://hdl.handle.net/11568/807688
http://hdl.handle.net/11568/807688