Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Jinghuan Wang"'
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Background Cardiac fibrosis is characterized by excessive extracellular matrix deposition that contributes to compromised cardiac function and potentially heart failure. Disruptor of telomeric silencing 1-like (Dot1L) is the catalytic enzyme
Externí odkaz:
https://doaj.org/article/55e56bfb2bae47a98f58a0c700f40374
Autor:
Jinghuan Wang, Wen Zhong, Qianwen Cheng, Chenxi Xiao, Jie Xu, Zhenghua Su, Haibi Su, Xinhua Liu
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 3, Pp n/a-n/a (2022)
Abstract Background The blood‐brain barrier (BBB) plays a principal role in the healthy and diseased central nervous systems, and BBB disruption after ischaemic stroke is responsible for increased mortality. Smyd2, a member of the SMYD‐methyltran
Externí odkaz:
https://doaj.org/article/b5e1243fec004caf96b646e323e79acd
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 23 (2021)
Background Neuron apoptosis is a pivotal process for brain damage in cerebral ischemia. Dot1L (disruptor of telomeric silencing 1‐like) is only known histone H3K79 methyltransferase. It is not clear whether the role and mechanism of Dot1L on cerebr
Externí odkaz:
https://doaj.org/article/acaafb420c7444a8810bc60738afbbaf
Autor:
Weijun Wu, Jinghuan Wang, Chenxi Xiao, Zhenghua Su, Haibi Su, Wen Zhong, Jianchun Mao, Xinhua Liu, Yi Zhun Zhu
Publikováno v:
Clinical and Translational Medicine, Vol 11, Iss 11, Pp n/a-n/a (2021)
Abstract Background The methylation of lysine residues has been involved in the multiple biological and diseases processes. Recently, some particular non‐histone proteins have been elucidated to be methylated by SMYD2, a SET and MYND domain protein
Externí odkaz:
https://doaj.org/article/4e01a827b07c465d9d02ee7c8fd565da
Autor:
Jinghuan Wang1, Qianwen Cheng1, Yuyu Zhang1, Chen Hong1, Jiayao Liu1, Xinhua Liu1 liuxinhua@fudan.edu.cn, Jun Chang1 jchang@fudan.edu.cn
Publikováno v:
Aging & Disease. Aug2023, Vol. 14 Issue 4, p1458-1471. 14p.
Publikováno v:
The FASEB Journal. 37
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7598bd11e83312c4d2fdec6eb5e5b9dd
https://doi.org/10.1096/fj.202201426rr
https://doi.org/10.1096/fj.202201426rr
Publikováno v:
Aging and disease.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5ff0558b90f21e0d088e7bb19d4388c
https://doi.org/10.14336/ad.2023.0119
https://doi.org/10.14336/ad.2023.0119
Autor:
Haibi Su, Jie Xu, Zhenghua Su, Chenxi Xiao, Jinghuan Wang, Wen Zhong, Chen Meng, Di Yang, Yizhun Zhu
Background Pressure overload-induced pathological cardiac hypertrophy is an independent predecessor of heart failure (HF), which remains the leading cause of worldwide mortality. However, current evidence on the molecular determinants of pathological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a8b37a525e8b34fb70a6b0c6d46dd4
https://doi.org/10.21203/rs.3.rs-1616637/v1
https://doi.org/10.21203/rs.3.rs-1616637/v1
Publikováno v:
Biochemical and Biophysical Research Communications. 528:671-677
Myocardial fibrosis is the pathological consequence of injury-induced fibroblastto-myofibroblast transition, resulting in increased stiffness and diminished cardiac function. Histone modification has been shown to play an important role in the pathog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbbe5a8c9c5feda850b1b4681437540d
https://doi.org/10.1016/j.bbrc.2020.05.115
https://doi.org/10.1016/j.bbrc.2020.05.115
Publikováno v:
Drug Design, Development and Therapy. 13:4145-4157
Background The role of catalpol in brain neurogenesis and newborn neuron survival has not been previously determined in permanent middle cerebral artery occlusion (pMCAO). Methods Fifty-four rats were divided into 6 groups: pMCAO (model, n=9); sham o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::479ea72ef01042c79da966d72e1d01ac
https://doi.org/10.2147/dddt.s223322
https://doi.org/10.2147/dddt.s223322