Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Jinghua Lu"'
Autor:
Rachel Erickson, Chang Huang, Cameron Allen, Joanna Ireland, Gwynne Roth, Zhongcheng Zou, Jinghua Lu, Bernard A. P. Lafont, Nicole L. Garza, Beniah Brumbaugh, Ming Zhao, Motoshi Suzuki, Lisa Olano, Joseph Brzostowski, Elizabeth R. Fischer, Homer L. Twigg, Reed F. Johnson, Peter D. Sun
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Severe COVID-associated lung injury is a major confounding factor of hospitalizations and death with no effective treatments. Here, we describe a non-classical fibrin clotting mechanism mediated by SARS-CoV-2 infected primary lung but not ot
Externí odkaz:
https://doaj.org/article/dfb1e8c9aa3047e59958ec0f9d7a69ea
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Understanding the molecular mechanism underlying the hierarchic binding between FcγRs and IgG antibodies is critical for therapeutic antibody engineering and FcγR functions. The recent determination of crystal structures of FcγRI-Fc complexes, how
Externí odkaz:
https://doaj.org/article/acd1d13f3df64530a0d310ed2e95b81d
Publikováno v:
PLoS ONE, Vol 18, Iss 9, p e0288351 (2023)
FcγRI (CD64) is the only high-affinity Fcγ receptor found on monocytes, macrophages, eosinophils, neutrophils and dendritic cells. It binds immunoglobulin G (IgG) antibody-antigen complexes at its Fc region to trigger key immune responses. CD64 con
Externí odkaz:
https://doaj.org/article/65d310ba5b09425aaaaecc45d7472c60
Autor:
Xuesong Cao, Hongtao Xie, Minglei Song, Jinghua Lu, Ping Ma, Boyu Huang, Mugui Wang, Yifu Tian, Fan Chen, Jun Peng, Zhaobo Lang, Guofu Li, Jian-Kang Zhu
Publikováno v:
The Innovation, Vol 4, Iss 1, Pp 100345- (2023)
Of the more than 370 000 species of higher plants in nature, fewer than 0.1% can be genetically modified due to limitations of the current gene delivery systems. Even for those that can be genetically modified, the modification involves a tedious and
Externí odkaz:
https://doaj.org/article/9cc3e51b18de4f9fa674d8ce0fc5ebed
Autor:
François Van Laethem, Abhisek Bhattacharya, Marco Craveiro, Jinghua Lu, Peter D. Sun, Alfred Singer
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Understanding the generation of an MHC-restricted T cell repertoire is the cornerstone of modern T cell immunology. The unique ability of αβT cells to only recognize peptide antigens presented by MHC molecules but not conformational antigens is ref
Externí odkaz:
https://doaj.org/article/76e87e0eec1242be99fc58fb598e83f1
Publikováno v:
eLife, Vol 11 (2022)
Dimorphic amino acids at positions 77 and 80 delineate HLA-C allotypes into two groups, C1 and C2, which associate with disease through interactions with C1 and C2-specific natural killer cell receptors. How the C1/C2 dimorphism affects T cell recogn
Externí odkaz:
https://doaj.org/article/5841704976004318b63b6c5d29ac4331
Autor:
Jinghua Lu, Yipei Ding, Wanqiu Zhang, Yuanyuan Qi, Jin Zhou, Naihan Xu, Yaou Zhang, Weidong Xie
Publikováno v:
Cells, Vol 12, Iss 9, p 1238 (2023)
Migration and invasion play crucial roles in the progression of hepatocellular carcinoma (HCC), but the underlying mechanisms are not clear. Analysis of clinical samples indicates that SQSTM1/p62 is highly expressed in HCC and seriously affects the p
Externí odkaz:
https://doaj.org/article/c6fb00c0bec4418c8afca5e93637cd89
Autor:
Yaoyun Niu, Yuehui Zhang, Wanqiu Zhang, Jinghua Lu, Yang Chen, Wenhui Hao, Jin Zhou, Lijun Wang, Weidong Xie
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is an important component of the innate immune system that mediates the secretion of the pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18. However, current studies ha
Externí odkaz:
https://doaj.org/article/d4fc2ab35e5045579852403365f7ac2f
Autor:
Wanqiu Zhang, Jinghua Lu, Yangyang Wang, Pengbo Sun, Tong Gao, Naihan Xu, Yaou Zhang, Weidong Xie
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 858 (2023)
Diabetic cardiomyopathy (DCM) is a myocardial disease independent of other cardiovascular diseases, such as coronary heart disease, hypertension, etc. Lipotoxicity is closely related to DCM. In this study, we investigated the mechanism of lipid metab
Externí odkaz:
https://doaj.org/article/bcf37b98d0a54c87a4b23a58709e167a
Autor:
Jinghua Lu, François Van Laethem, Abhisek Bhattacharya, Marco Craveiro, Ingrid Saba, Jonathan Chu, Nicholas C. Love, Anastasia Tikhonova, Sergei Radaev, Xiaoping Sun, Annette Ko, Tomer Arnon, Eric Shifrut, Nir Friedman, Nan-Ping Weng, Alfred Singer, Peter D. Sun
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
For T cells, functional antigen receptors are selected in the thymus from a pre-selection repertoire by interaction with self MHCs. Here the authors show that specific, non-germline coded features located in the complementarity determining region 3 o
Externí odkaz:
https://doaj.org/article/2135b8948a994dbda344f75d21b684fb