Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Jingen Zhu"'
Autor:
Jingen Zhu, Himanshu Batra, Neeti Ananthaswamy, Marthandan Mahalingam, Pan Tao, Xiaorong Wu, Wenzheng Guo, Andrei Fokine, Venigalla B. Rao
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Designing artificial viral vectors (AVVs) programmed with biomolecules that can enter human cells and carry out molecular repairs will have broad applications. Here, we describe an assembly-line approach to build AVVs by engineering the well
Externí odkaz:
https://doaj.org/article/f876df16271b41faa46a7605e13a1ee3
Autor:
Jingen Zhu, Swati Jain, Jian Sha, Himanshu Batra, Neeti Ananthaswamy, Paul B. Kilgore, Emily K. Hendrix, Yashoda M. Hosakote, Xiaorong Wu, Juan P. Olano, Adeyemi Kayode, Cristi L. Galindo, Simran Banga, Aleksandra Drelich, Vivian Tat, Chien-Te K. Tseng, Ashok K. Chopra, Venigalla B. Rao
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT The U.S. Food and Drug Administration-authorized mRNA- and adenovirus-based SARS-CoV-2 vaccines are intramuscularly injected in two doses and effective in preventing COVID-19, but they do not induce efficient mucosal immunity or prevent vira
Externí odkaz:
https://doaj.org/article/bce3c0d8931d4e4fb22673c9a20b9eda
Autor:
Jarin Taslem Mourosi, Ayobami Awe, Wenzheng Guo, Himanshu Batra, Harrish Ganesh, Xiaorong Wu, Jingen Zhu
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 20, p 12146 (2022)
Bacteriophages (phages), as natural antibacterial agents, are being rediscovered because of the growing threat of multi- and pan-drug-resistant bacterial pathogens globally. However, with an estimated 1031 phages on the planet, finding the right phag
Externí odkaz:
https://doaj.org/article/842dbde8657c43f4bb2abf306fd05a0f
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
Bacteriophages (phages) are viruses that infect bacteria and use them as replication factories to assemble progeny phages. Bacteria have evolved powerful defense mechanisms to destroy the invading phages by severing their genomes soon after entry int
Externí odkaz:
https://doaj.org/article/aa2042bee2a0440da6879666dfe0d35f
Publikováno v:
Bio-Protocol, Vol 10, Iss 7 (2020)
A viral vector that can safely and efficiently deliver large and diverse molecular cargos into cells is the holy grail of curing many human diseases. Adeno-associated virus (AAV) has been extensively used but has a very small capacity. The prokaryoti
Externí odkaz:
https://doaj.org/article/de1b857ceb7445bb8b5ea5602100ccf8
Autor:
Pan Tao, Marthandan Mahalingam, Jingen Zhu, Mahtab Moayeri, Jian Sha, William S. Lawrence, Stephen H. Leppla, Ashok K. Chopra, Venigalla B. Rao
Publikováno v:
mBio, Vol 9, Iss 5 (2018)
ABSTRACT Bacillus anthracis and Yersinia pestis, the causative agents of anthrax and plague, respectively, are two of the deadliest pathogenic bacteria that have been used as biological warfare agents. Although Biothrax is a licensed vaccine against
Externí odkaz:
https://doaj.org/article/8e99a89944ec4a70998d621b245a3deb
Autor:
Pan Tao, Marthandan Mahalingam, Jingen Zhu, Mahtab Moayeri, Michelle L. Kirtley, Eric C. Fitts, Jourdan A. Andersson, William S. Lawrence, Stephen H. Leppla, Ashok K. Chopra, Venigalla B. Rao
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Bioterrorism remains as one of the biggest challenges to global security and public health. Since the deadly anthrax attacks of 2001 in the United States, Bacillus anthracis and Yersinia pestis, the causative agents of anthrax and plague, respectivel
Externí odkaz:
https://doaj.org/article/8a34650f189348629f8a72016ea0aada
Autor:
Dong Qian, Qiong Nan, Yueming Yang, Hui Li, Yuelong Zhou, Jingen Zhu, Qifeng Bai, Pan Zhang, Lizhe An, Yun Xiang
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143174 (2015)
The villin/gelsolin/fragmin superfamily is a major group of Ca2+-dependent actin-binding proteins (ABPs) involved in various cellular processes. Members of this superfamily typically possess three or six tandem gelsolin-like (G) domains, and each dom
Externí odkaz:
https://doaj.org/article/8a11c200b7ff4a709e42833259f6dd0b
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102407 (2014)
The regulation of pollen development and pollen tube growth is a complicated biological process that is crucial for sexual reproduction in flowering plants. Annexins are widely distributed from protists to higher eukaryotes and play multiple roles in
Externí odkaz:
https://doaj.org/article/7849882b979a4451b1a9e2a06e786105
Publikováno v:
ACS Synthetic Biology. 10:2639-2648
Bacteriophage T4 has enormous potential for biomedical applications due to its large size, capsid architecture, and high payload capability for protein and DNA delivery. However, it is not very easy to genetically engineer its genome heavily modified