Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jingdong Qin"'
Quantum dot‐mediated delivery of siRNA to inhibit sphingomyelinase activities in brain‐derived cells
Autor:
Jingdong Qin, James B. Delehanty, Kimihiro Susumu, Glyn Dawson, Igor L. Medintz, Ted Getz, Philip E. Dawson
Publikováno v:
Journal of Neurochemistry. 139:872-885
The use of RNAi to suppress protein synthesis offers a potential way of reducing the level of enzymes or the synthesis of mutant toxic proteins but there are few tools currently available for their delivery. To address this problem, bioconjugated qua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1254cded3e1c6f0b07ee1f6bc5b1be7
https://doi.org/10.1111/jnc.13841
https://doi.org/10.1111/jnc.13841
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1861:78-90
Increased synthesis of hyaluronic acid (HA) is often associated with increased metastatic potential and invasivity of tumor cells. 4-Methylumbelliferone (MU) is an inhibitor of HA synthesis, and has been studied as a potential anti-tumor drug to inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2cf7d43cc37bf82107a9e80ecb78436
https://doi.org/10.1016/j.bbalip.2015.11.001
https://doi.org/10.1016/j.bbalip.2015.11.001
Publikováno v:
Cancer Research. 80:3361-3361
Claudin 18.2 (CLDN 18.2) is a major component of the tight junctions and is highly expressed in several cancers including gastric (80%), esophageal (80%), pancreatic (60%) and lung cancers, but only expressed at very low levels in healthy tissues. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09d77f55d41f9478a77ea12d8600e26b
https://doi.org/10.1158/1538-7445.am2020-3361
https://doi.org/10.1158/1538-7445.am2020-3361
Publikováno v:
Cancer Research. 80:534-534
This research aimed to produce anti-claudin18.2 (CLDN 18.2)/anti-PD-L1 bispecific antibodies to enhance the therapeutic index and expand the responsive population of the parent anti-CLDN 18.2 and anti-PD-L1 antibodies through the mechanisms of tumor-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f75f0954236ffc6863d58b5079b2b54
https://doi.org/10.1158/1538-7445.am2020-534
https://doi.org/10.1158/1538-7445.am2020-534
Publikováno v:
Biochemical and biophysical research communications. 500(3)
Sphingosine-1-phosphate is synthesized by two sphingosine kinases, cytosolic SK1 and nuclear SK2 but SK2 expression was much higher than SK1in mouse skin fibroblasts. However, in SK2-/- cells, SK1 expression was markedly increased to SK2 levels where
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e04fcec98e90fa73af6380f66209d31
https://pubmed.ncbi.nlm.nih.gov/29673590
https://pubmed.ncbi.nlm.nih.gov/29673590
Publikováno v:
Journal of Biological Chemistry. 285:14134-14143
Both cultured neonatal rat hippocampal neurons and differentiated oligodendrocytes rapidly metabolized exogenous C2- and C6-ceramides to sphingosine (Sph) and sphingosine 1-phosphate (S1P) but only minimally to C16–24-ceramides. Dihydrosphinolipids
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1ae40a7eb4c26561afe21ba1113d458
https://doi.org/10.1074/jbc.m109.076810
https://doi.org/10.1074/jbc.m109.076810
Publikováno v:
Journal of Neuroscience Research. 85:977-984
Multiple sclerosis (MS) is a common autoimmune neurodegenerative disease of unknown cause, which results in inflammation and plaques of demyelination in brain and eventual axonal degeneration. We report the novel presence of oxidized phosphatidylchol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2517f416858e9135b2d1f1542426527
https://doi.org/10.1002/jnr.21206
https://doi.org/10.1002/jnr.21206
Publikováno v:
Journal of Fluorine Chemistry. 127:1222-1227
Novel artificial anionic receptors N -flurobenzoyl- N ′-phenylthioureas were synthesized by simple steps in good yields. The binding properties for anions of these N -flurobenzoyl- N ′-phenylthioureas and 2 N -benzoyl- N ′-phenyl thiourea were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d41337ad9771d473be129bd9efdf268a
https://doi.org/10.1016/j.jfluchem.2006.06.018
https://doi.org/10.1016/j.jfluchem.2006.06.018
Autor:
Glyn Dawson, Jingdong Qin
Publikováno v:
Biochemical and Biophysical Research Communications. 404:321-323
The immunomodulator drug Gilenya (FTY720), marketed as the first oral sphingosine-1-phosphate receptor (S1P-R) modulator for treatment of Multiple Sclerosis (MS) also inhibits lysosomal acid sphingomyelinase (ASMase). Treatment of cultured cells for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84dfe6d53f2cb80bb40ed9f642e35471
https://doi.org/10.1016/j.bbrc.2010.11.115
https://doi.org/10.1016/j.bbrc.2010.11.115
Publikováno v:
Acta Crystallographica Section E Structure Reports Online. 62:o2880-o2882
In the crystal structure of the title compound, C14H11FN2OS, the molecules form centrosymmetric hydrogen-bonded dimers, with the S atom forming an intermolecular hydrogen bond with the H atom of an NH group.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5124a25febb490eab38d16026b82d86
https://doi.org/10.1107/s1600536806021878
https://doi.org/10.1107/s1600536806021878