Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Jingdan Liang"'
Autor:
Jialiang Wang, Xiaojie Wang, Xixi Li, LiangLiang Kong, Zeqian Du, Dandan Li, Lixia Gou, Hao Wu, Wei Cao, Xiaozheng Wang, Shuangjun Lin, Ting Shi, Zixin Deng, Zhijun Wang, Jingdan Liang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Assembly-line polyketide synthases (PKSs) are molecular factories that produce diverse metabolites with wide-ranging biological activities. PKSs usually work by constructing and modifying the polyketide backbone successively. Here, we presen
Externí odkaz:
https://doaj.org/article/71aac50a883b4a9db693ee8a82178be3
Autor:
Jialiang Wang, Dandan Li, Lu Chen, Wei Cao, Liangliang Kong, Wei Zhang, Tristan Croll, Zixin Deng, Jingdan Liang, Zhijun Wang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The catalytic domains in nonribosomal peptide synthetases (NRPSs) are responsible for a choreography of events that elongates substrates into natural products. Here, the authors present cryo-EM structures of a siderophore-producing dimeric NRPS elong
Externí odkaz:
https://doaj.org/article/0b0c9e73b15c4befaa48aa4491868927
Autor:
Jialiang Wang, Jingdan Liang, Lu Chen, Wei Zhang, Liangliang Kong, Chao Peng, Chen Su, Yi Tang, Zixin Deng, Zhijun Wang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Biosynthesis of the statin precursor lovastatin depends on the LovB–LovC megasynthase complex. Here, the authors present cryoEM structures of LovB–LovC and core LovB, providing structural insights into the catalytic cycle underlying lovastatin pr
Externí odkaz:
https://doaj.org/article/78a7ab70c6d545e6b1e3702fbf340601
Autor:
Yan Yang, Guanpeng Xu, Jingdan Liang, Ying He, Lei Xiong, Hui Li, Douglas Bartlett, Zixin Deng, Zhijun Wang, Xiang Xiao
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract DNA phosphorothioate (PT) modification is a sulfur modification on the backbone of DNA introduced by the proteins DndA-E. It has been detected within many bacteria isolates and metagenomic datasets, including human pathogens, and is consider
Externí odkaz:
https://doaj.org/article/1ff47aaf03a04b9eb534c3de6f7b364a
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
DNA sulfur modification is a unique modification occurring in the sugar-phosphate backbone of DNA, with a nonbridging oxygen atom substituted with sulfur in a sequence-specific and Rp stereo-specific manner. Bioinformatics, RNA-seq, and in vitro tran
Externí odkaz:
https://doaj.org/article/3f1a8fc6a234417d976ee3ea6b1f247a
Autor:
Daofeng Dai, Aiqin Du, Kangli Xiong, Tianning Pu, Xiufen Zhou, Zixin Deng, Jingdan Liang, Xinyi He, Zhijun Wang
Publikováno v:
Frontiers in Microbiology, Vol 7 (2016)
DNA phosphorothioation, conferred by dnd genes, was originally discovered in the soil-dwelling bacterium Streptomyces lividans, and thereafter found to exist in various bacterial genera. However, the physiological significance of this sulfur modifica
Externí odkaz:
https://doaj.org/article/9d31283d9d8a4de8b2e24169704a3b0c
Autor:
Xianhui An, Wei Xiong, Yan Yang, Fuhou Li, Xiufen Zhou, Zhijun Wang, Zixin Deng, Jingdan Liang
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51265 (2012)
Many bacterial species modify their DNA with the addition of sulfur to phosphate groups, a modification known as DNA phosphorothioation. DndA is known to act as a cysteine desulfurase, catalyzing a key biochemical step in phosphorothioation. However,
Externí odkaz:
https://doaj.org/article/2c38c0b952724b59820f5cc3f2169bb2
Autor:
Fukun Chen, Zhenyi Zhang, Kui Lin, Tianle Qian, Yan Zhang, Delin You, Xinyi He, Zhijun Wang, Jingdan Liang, Zixin Deng, Geng Wu
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36635 (2012)
DNA phosphorothioation is widespread among prokaryotes, and might function to restrict gene transfer among different kinds of bacteria. There has been little investigation into the structural mechanism of the DNA phosphorothioation process. DndA is a
Externí odkaz:
https://doaj.org/article/45c05a6cf6774c64ae4332b53ac8764a
Autor:
Shubing Tang, Min Li, Lixiang Chen, Aguang Dai, Zhi Liu, Mangteng Wu, Jingyi Yang, Hongyun Hao, Jingdan Liang, Xiaohui Zhou, Zhikang Qian
Publikováno v:
ACS Applied Bio Materials. 5:3329-3337
Thousands of breakthrough infections are confirmed after intramuscular (i.m.) injection of the approved vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Two major factors might contribute to breakthrough infections. One
Publikováno v:
International Journal of Environmental Research and Public Health; Volume 19; Issue 16; Pages: 9826
The debate over whether involution causes anxiety has persisted because no studies have attempted to quantify introversion and study its relationship to anxiety. This study quantified involution and explored its relationship with anxiety, provided ev