Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Jingchun Qu"'
Autor:
Yichuan Liu, Hui-Qi Qu, Jingchun Qu, Xiao Chang, Frank D. Mentch, Kenny Nguyen, Lifeng Tian, Joseph Glessner, Patrick M. A. Sleiman, Hakon Hakonarson
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-6 (2022)
Abstract Background Asthma is a complex condition largely attributed to the interactions among genes and environments as a heterogeneous phenotype. Obesity is significantly associated with asthma development, and genetic studies on obese vs. non-obes
Externí odkaz:
https://doaj.org/article/84e0f1c57f91478296a976802fd7faf5
Insights into non-autoimmune type 1 diabetes with 13 novel loci in low polygenic risk score patients
Autor:
Jingchun Qu, Hui-Qi Qu, Jonathan P. Bradfield, Joseph T. Glessner, Xiao Chang, Lifeng Tian, Michael March, John J. Connolly, Jeffrey D. Roizen, Patrick M. A. Sleiman, Hakon Hakonarson
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract With polygenic risk score (PRS) for autoimmune type 1 diabetes (T1D), this study identified T1D cases with low T1D PRS and searched for susceptibility loci in these cases. Our hypothesis is that genetic effects (likely mediated by relatively
Externí odkaz:
https://doaj.org/article/ed9a2299120543618940a4496e3810ca
Autor:
Hui-Qi Qu, Jingchun Qu, Jonathan Bradfield, Luc Marchand, Joseph Glessner, Xiao Chang, Michael March, Jin Li, John J. Connolly, Jeffrey D. Roizen, Patrick Sleiman, Constantin Polychronakos, Hakon Hakonarson
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Hui-Qi Qu et al. present a case-control association study to examine the genetic architecture of European patients with type 1 diabetes (T1D) of low genetic risk score. They identify 41 loci associated with T1D of low genetic risk score, including re
Externí odkaz:
https://doaj.org/article/299624c58fdb434482bd26884aea79ed
Autor:
Hui-Qi Qu, Joseph Glessner, Jingchun Qu, Steven Gilhool, Frank Mentch, Ian Campbell, Patrick Sleiman, John J. Connolly, Hakon Hakonarson
Publikováno v:
iScience, Vol 25, Iss 7, Pp 104650- (2022)
Summary: Plasma metabolomics represents a potentially powerful approach to understand the biochemical mechanisms of nutrition and metabolism in asthma. This study aims to acquire knowledge on plasma metabolites in asthma, which may provide avenues fo
Externí odkaz:
https://doaj.org/article/cb0a7ddac76a4d6c9c2d8f5682f5ec8e
Publikováno v:
Viruses, Vol 12, Iss 10, p 1174 (2020)
To address the expression pattern of the SARS-CoV-2 receptor ACE2 and the viral priming protease TMPRSS2 in the respiratory tract, this study investigated RNA sequencing transcriptome profiling of samples of airway and oral mucosa. As shown, ACE2 has
Externí odkaz:
https://doaj.org/article/790aa7517f9f4d1ca456fc104dcb25f6
Autor:
Yichuan Liu, Hui-Qi Qu, Xiao Chang, Jingchun Qu, Frank D Mentch, Kenny Nguyen, Lifeng Tian, Joseph Glessner, Patrick M A Sleiman, Hakon Hakonarson
Publikováno v:
Human Molecular Genetics. 31:3769-3776
Mental disorders present a global health concern and have limited treatment options. In today’s medical practice, medications such as antidepressants are prescribed not only for depression but also for conditions such as anxiety and attention defic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39c34476ede0bb494ee8d1060d3e2b6
https://doi.org/10.1093/hmg/ddac129
https://doi.org/10.1093/hmg/ddac129
Autor:
Hui-Qi Qu, Jingchun Qu, Courtney Vaccaro, Xiao Chang, Frank Mentch, Jin Li, Fernanda Mafra, Kenny Nguyen, Michael Gonzalez, Michael March, Renata Pellegrino, Joseph Glessner, Patrick Sleiman, Charlly Kao, Hakon Hakonarson
Publikováno v:
Rheumatology. 61:3497-3501
Objectives JDM is a serious autoimmune and complex genetic disease. Another autoimmune genetic disease, type 1 diabetes (T1D), has been observed for significantly increased prevalence in families with JDM, while increased JDM risk has also been obser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fd7aa94e1b9cb31bab7b924b70cb381
https://doi.org/10.1093/rheumatology/keac100
https://doi.org/10.1093/rheumatology/keac100
Autor:
Hui‐Qi Qu, Jingchun Qu, Joseph Glessner, Yichuan Liu, Frank Mentch, Xiao Chang, Michael March, Jin Li, Jeffrey D. Roizen, John J. Connolly, Patrick Sleiman, Hakon Hakonarson
Publikováno v:
Pediatr Diabetes
Precise risk prediction of type 1 diabetes (T1D) facilitates early intervention and identification of risk factors prior to irreversible beta-islet cell destruction, and can significantly improve T1D prevention and clinical care. Sharp et al. (2019)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2431e39fe0a32d996c1eab0baaaebe5
https://doi.org/10.1111/pedi.13310
https://doi.org/10.1111/pedi.13310
Autor:
Yichuan Liu, Lifeng Tian, Patrick M. A. Sleiman, Joseph T. Glessner, Jingchun Qu, Kenny Nguyen, Hakon Hakonarson, Xiao Chang, Hui-Qi Qu
Publikováno v:
Exp Biol Med (Maywood)
Current understanding of the underlying molecular network and mechanism for attention-deficit hyperactivity disorder (ADHD) is lacking and incomplete. Previous studies suggest that genomic structural variations play an important role in the pathogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1402b41fb850512286b492cfbf73d4c0
https://doi.org/10.1177/15353702211018970
https://doi.org/10.1177/15353702211018970
Autor:
Hui-Qi Qu, Joseph Glessner, Jingchun Qu, Frank Mentch, Ian Campbell, Patrick Sleiman, John J Connolly, Hakon Hakonarson
Publikováno v:
Metabolomics : Official journal of the Metabolomic Society. 18(12)
Background Previous study has shown that dyslipidemia is common in patients with Sickle cell disease (SCD) and is associated with more serious SCD complications. Methods This study investigated systematically dyslipidemia in SCD using a state-of-art
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::882a83787ef32fdd0ece678aa60774c1
https://pubmed.ncbi.nlm.nih.gov/36459297
https://pubmed.ncbi.nlm.nih.gov/36459297