Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Jing-gen Liu"'
Autor:
Yu-Jun Wang, Gui-Ying Zan, Cenglin Xu, Xue-Ping Li, Xuelian Shu, Song-Yu Yao, Xiao-Shan Xu, Xiaoyun Qiu, Yexiang Chen, Kai Jin, Qi-Xin Zhou, Jia-Yu Ye, Yi Wang, Lin Xu, Zhong Chen, Jing-Gen Liu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Ample evidence has suggested the stress etiology of depression, but the underlying mechanism is not fully understood yet. Here, we report that chronic social defeat stress (CSDS) attenuates the excitatory output of the claustrum (CLA) to the
Externí odkaz:
https://doaj.org/article/1b785317c072493d8496ce17573abaa2
Autor:
Fang-bing Shao, Jun-fan Fang, Si-si Wang, Meng-ting Qiu, Dan-ning Xi, Xiao-ming Jin, Jing-gen Liu, Xiao-mei Shao, Zui Shen, Yi Liang, Jian-qiao Fang, Jun-ying Du
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-22 (2021)
Abstract Chronic pain easily leads to concomitant mood disorders, and the excitability of anterior cingulate cortex (ACC) pyramidal neurons (PNs) is involved in chronic pain-related anxiety. However, the mechanism by which PNs regulate pain-related a
Externí odkaz:
https://doaj.org/article/18f8f70a2d9a4b679b3893f9999710e4
Autor:
Gui-Ying Zan, Yu-Jun Wang, Xue-Ping Li, Jun-Fan Fang, Song-Yu Yao, Jun-Ying Du, Qian Wang, Xiang Sun, Rui Liu, Xiao-Mei Shao, Jian-Dong Long, Jing-Rui Chai, Ying-Zhi Deng, Ye-Qing Chen, Qing-Lin Li, Jian-Qiao Fang, Zhi-Qiang Liu, Jing-Gen Liu
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109913- (2021)
Summary: Opiates produce a strong rewarding effect, but abstinence from opiate use emerges with severe negative emotions. Depression is one of the most frequent emotion disorders associated with opiate abstinence, which is thought to be a main cause
Externí odkaz:
https://doaj.org/article/28a139f7693d43c18cec2da3add1381a
Autor:
Dong-Liang Jiao, Yan Chen, Yao Liu, Yun-Yue Ju, Jian-Dong Long, Jiang Du, Chang-Xi Yu, Yu-Jun Wang, Min Zhao, Jing-Gen Liu
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Abuse of methamphetamine (METH), a powerful addictive amphetamine-type stimulants (ATS), is becoming a global public health problem. The gamma-aminobutyric acid (GABA)ergic system plays a critical role in METH use disorders. By using rat METH conditi
Externí odkaz:
https://doaj.org/article/5fea4bba473b4e2fbc5e45fc8b2e8e83
Autor:
Yunyun Li, Xiaodie Liu, Qianqian Fu, Wenxiang Fan, Xiaomei Shao, Jianqiao Fang, Jing-Gen Liu, Chi Xu
Publikováno v:
Stem Cells. 41:384-399
Although electroacupuncture (EA) stimulation is a widely used therapy for chronic pain and comorbid psychiatric disorders, its long-term effects on chronic neuropathic pain-induced depression and the underlying mechanisms remain elusive. In the prese
Publikováno v:
Neurochemical Research. 48:1531-1542
Our previous study found that activation of adenosine A1 receptor (A
Autor:
Xiang-Yan, Wei, Jian-Dong, Long, Jing-Rui, Chai, Jing, Chen, Jian-Ping, Gao, Yu-Jun, Wang, Jing-Gen, Liu
Publikováno v:
Biochemical and Biophysical Research Communications. 614:219-224
Cepharanthine is an alkaloid that isolated from Stephania cepharantha Hayata, however,its analgesic properties are unclear and the molecular targets that mediating Cepharanthine-induced analgesia are not explored yet. In the current study, mice pai
Publikováno v:
Acta Pharmacol Sin
Dezocine, a synthetic opioid, introduced in 1970s as an analgesic, was redeveloped for relieving moderate to severe pain by Yangtze River Pharmaceutical Group in China in 2009. To date, dezocine occupies 45% of China’s opioid analgesic market. Alon
Our previous study found that activation of adenosine A1 receptor (A1R) induced phosphorylation of delta opioid receptor (DOR) and desensitization of its downstream signaling molecules, cAMP and Akt. To further investigate the effect of A1R agonist o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f14a9003e8d1a72c3f68e26214c0f4d2
https://doi.org/10.21203/rs.3.rs-2205407/v1
https://doi.org/10.21203/rs.3.rs-2205407/v1
Autor:
Qian He, Jing-Rui Chai, Liming Shao, Yujun Wang, Zixiang Li, Yuan-Yuan Wei, Zhuibai Qiu, Rongrong Ye, Wei Li, Wei Fu, Linqian Yu, Xiao Liu, Jing-Gen Liu, Shuang Jiang, Qiong Xie, Linghui Kong
Publikováno v:
Journal of Medicinal Chemistry. 64:12414-12433
The search for selective kappa opioid receptor (κOR) agonists with an improved safety profile is an area of interest in opioid research. In this work, a series of m-substituted analogs were designed, synthesized, and assayed, resulting in the identi