Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jing-fen Han"'
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 11, Iss , Pp 52-64 (2018)
Novel strategies are needed to solve the conundrum of achieving clinical efficacy with high vector copy numbers (VCNs) in hematopoietic stem cells (HSCs) while attempting to minimize the potential risk of oncogenesis in lentiviral vector (LV)-mediate
Externí odkaz:
https://doaj.org/article/0e16d0a5af15429c9a1987ce4e1fbbd7
Publikováno v:
Drug Metabolism and Disposition. 36:745-752
Human cytochrome P450 1B1 (CYP1B1) plays a critical role in the metabolic activation of a variety of procarcinogens, including 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). The existence of human CYP1B1 missense genetic variants has been de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9b8f0fe62ab496a766d0367234b7483
https://doi.org/10.1124/dmd.107.016824
https://doi.org/10.1124/dmd.107.016824
Publikováno v:
Toxicological Sciences. 91:42-48
Paraquat (1,1'-dimethyl-4,4'-bipyridylium dichloride) is a widely used herbicide and is highly toxic to human and animals. The mechanisms of paraquat toxicity involve the generation of superoxide anion through the process of redox cycling. NADPH-cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::135e769c47019e490cd8a525e5aa5ee3
https://doi.org/10.1093/toxsci/kfj139
https://doi.org/10.1093/toxsci/kfj139
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 35(1)
The importance of genetic variation in clinical response to various drugs is now well recognized. Identification of genetic biomarkers that can predict efficacy and toxicity of chemotherapeutic drugs in cancer patients holds great promise in treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c459be2ede29f467eb3ee216b982118f
https://pubmed.ncbi.nlm.nih.gov/17062779
https://pubmed.ncbi.nlm.nih.gov/17062779
Publikováno v:
Toxicological Sciences; May2006, Vol. 91 Issue 1, p42-48, 7p, 1 Diagram, 6 Graphs