Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jing-Si Zha"'
Autor:
Li Song, Qiu‐Ling Pan, Gui‐Feng Zhou, Sheng‐Wei Liu, Bing‐Lin Zhu, Pei‐Jia Lin, Xiao‐Tong Hu, Jing‐Si Zha, Yan Long, Biao Luo, Jian Chen, Ying Tang, Jing Tang, Xiao‐Jiao Xiang, Xiao‐Yong Xie, Xiao‐Juan Deng, Guo‐Jun Chen
Publikováno v:
Advanced Science, Vol 11, Iss 11, Pp n/a-n/a (2024)
Abstract It is long been suggested that one‐carbon metabolism (OCM) is associated with Alzheimer's disease (AD), whereas the potential mechanisms remain poorly understood. Taking advantage of chemical biology, that mitochondrial serine hydroxymethy
Externí odkaz:
https://doaj.org/article/05748bcfdf2b4138810dae2b4810b884
Autor:
Zhuo Min, Ying Tang, Xiao-Tong Hu, Bing-Lin Zhu, Yuan-Lin Ma, Jing-Si Zha, Xiao-Juan Deng, Zhen Yan, Guo-Jun Chen
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
The α-secretase “a disintegrin and metalloproteinase domain-containing protein” (ADAM10) is involved in the processing of amyloid precursor protein (APP). Upregulation of ADAM10 precludes the generation of neurotoxic β-amyloid protein (Aβ) and
Externí odkaz:
https://doaj.org/article/0b056c7396734d05b94c50d8de558cef
Autor:
Yu-Jie Lai, Zhen Yan, Yan Long, Xuefeng Wang, Xiao-Juan Deng, Lu Liu, Guojun Chen, Binglin Zhu, Jing-Si Zha, Xiao-Tong Hu
Publikováno v:
Oncotarget
// Jing-Si Zha 1, * , Bing-Lin Zhu 1, * , Lu Liu 1 , Yu-Jie Lai 1 , Yan Long 1 , Xiao-Tong Hu 1 , Xiao-Juan Deng 1 , Xue-Feng Wang 1 , Zhen Yan 2 and Guo-Jun Chen 1 1 Department of Neurology, The First Affiliated Hospital of Chongqing Medical Univers
Autor:
Zhen Yan, Zhuo Min, Guojun Chen, Jing-Si Zha, Binglin Zhu, Xiao-Juan Deng, Xiao-Tong Hu, Ying Tang, Yuanlin Ma
Publikováno v:
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Frontiers in Molecular Neuroscience, Vol 11 (2018)
The α-secretase “a disintegrin and metalloproteinase domain-containing protein” (ADAM10) is involved in the processing of amyloid precursor protein (APP). Upregulation of ADAM10 precludes the generation of neurotoxic β-amyloid protein (Aβ) and
Autor:
Binglin Zhu, Li-Tian Hu, Xiao-Tong Hu, Jing-Si Zha, Guojun Chen, Yan Long, John H. Zhang, Yu-Jie Lai
Publikováno v:
Biochemical and biophysical research communications. 486(2)
HMGCS2 (mitochondrial 3-hydroxy-3-methylglutaryl-COA synthase 2) is a control enzyme in ketogenesis. The mitochondrial localization and interaction with APP (β-amyloid precursor protein) suggest that HMGCS2 may play a role in the pathophysiology of
Publikováno v:
Journal of the neurological sciences. 360
Copine VI (CPNE6) is a member of copines family, a calcium-dependent phospholipids-binding protein group found in many diverse eukaryotic organisms. Although earlier studies have shown that CPNE6 is almost exclusively expressed in brain, the exact bi
Autor:
Jun Xiang, Feng Yang, Wen Zhu, Min Cai, Xiang-Ting Li, Jing-Si Zhang, Zhong-Hai Yu, Wen Zhang, Ding-Fang Cai
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract The pathogenesis of Alzheimer’s disease (AD) involves multiple cell types including endothelial cells, glia, and neurons. It suggests that therapy against single target in single cell type may not be sufficient to treat AD and therapies wi
Externí odkaz:
https://doaj.org/article/76080194c0d046b4b2df9acc6bfc0146
Autor:
Jun Xiang, Wen Zhang, Xiao-Fang Cai, Min Cai, Zhong-Hai Yu, Feng Yang, Wen Zhu, Xiang-Ting Li, Ting Wu, Jing-Si Zhang, Ding-Fang Cai
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 16, Iss , Pp 302-312 (2019)
β-amyloid (Aβ) plays an essential role in the pathogenesis of Alzheimer’s disease (AD). Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) is indispensable for Aβ production, and knockout of BACE1 has no overt phenotypes in mouse. Thu
Externí odkaz:
https://doaj.org/article/ddf2458ef5e0427794009065bf25b8a6
Autor:
Jing-Si Zhang, Yun-Long Zhang, Hong-Xia Wang, Yun-Long Xia, Lei Wang, Yi-Nong Jiang, Hui-Hua Li, Ying Liu
Publikováno v:
Cellular Physiology and Biochemistry, Vol 34, Iss 4, Pp 1137-1151 (2014)
Background/Aims: Angiotensin II (Ang II) mediated signaling plays a key role in the development of chronic kidney damage that contributes to renal fibrosis. However, the gene expression changes regulated by Ang II in the early stage of acute renal in
Externí odkaz:
https://doaj.org/article/fc1f8596d76640fa99520b563ae1cb1e