Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Jing-Kang Shen"'
Autor:
Jing-Kang Shen, Mao-Sheng Cheng, Yu-Fang Shi, Zhi-Heng Yang, Chao Yu, Pei-Wei Fan, Wen-Yan Li, Xu-Qiong Xiong, Dong-Mei Zhao
Publikováno v:
Molecules, Vol 17, Iss 5, Pp 5497-5507 (2012)
A series of novel quinoline-3-carboxamide derivatives 10–17 and 23–27 were designed and synthesized as cholesteryl ester transfer protein (CETP) inhibitors. All of them exhibited activity against CETP. Particularly, compounds 24 and 26 displayed
Externí odkaz:
https://doaj.org/article/2e2c756af0d045388703262bfa020eb1
Autor:
Li-Na Zhang, Lei Xu, Hua-Yong Zhou, Ling-Yan Wu, Yuan-Yuan Li, Tao Pang, Chun-Mei Xia, Bei-Ying Qiu, Min Gu, Tian-Cheng Dong, Jing-Ya Li, Jing-Kang Shen, Jia Li
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72092 (2013)
AMP-activated protein kinase (AMPK) is an energy sensor of metabolism that is an attractive therapeutic target for type 2 diabetes mellitus and metabolic syndrome. Using a homogeneous scintillation proximity assay (SPA), we identified a new small-mol
Externí odkaz:
https://doaj.org/article/9a67735e4503487aa1d252167a9eb699
Autor:
Jin-peng Pei, Yue Wang, Lan-ping Ma, Xin Wang, Liang Liu, Yu Zhang, Rui Jin, Zhi-qiang Ren, Yan Deng, Jing-kang Shen, Tao Meng, Ker Yu
Publikováno v:
Acta Pharmacologica Sinica. 44:1290-1303
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0b9fe5d61534ee79e94286a5a46c145
https://doi.org/10.1038/s41401-022-01047-6
https://doi.org/10.1038/s41401-022-01047-6
Autor:
Ze-Hong Miao, Jing-Kang Shen, Jian Ding, Yi Chen, Lin-Jiang Tong, Lan-Ping Ma, Xia-Juan Huan, Jun-Mei Yi, Tao Meng, Ying-Qing Wang, Wei Wang
PDF - 84K, Legends for Supplementary Figures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5993ad4e2f9c2bd8ad5bac8c2be322ab
https://doi.org/10.1158/1535-7163.22500784.v1
https://doi.org/10.1158/1535-7163.22500784.v1
Autor:
Ze-Hong Miao, Jing-Kang Shen, Jian Ding, Yi Chen, Lin-Jiang Tong, Lan-Ping Ma, Xia-Juan Huan, Jun-Mei Yi, Tao Meng, Ying-Qing Wang, Wei Wang
PDF - 194K, MT189 causes cellular microtubulin depolymerization in a time-dependent manner and induces reversible M arrest.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4623975ae1c0433583955777920f0d41
https://doi.org/10.1158/1535-7163.22500799
https://doi.org/10.1158/1535-7163.22500799
Autor:
Ze-Hong Miao, Jing-Kang Shen, Jian Ding, Yi Chen, Lin-Jiang Tong, Lan-Ping Ma, Xia-Juan Huan, Jun-Mei Yi, Tao Meng, Ying-Qing Wang, Wei Wang
PDF - 37K, MT189 inhibits the proliferation of HeLa and SMMC-7721 cells in a time- and concentration-dependent manner.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b0f8157cd51802001e5c4840fd4b74d
https://doi.org/10.1158/1535-7163.22500796
https://doi.org/10.1158/1535-7163.22500796
Autor:
Ze-Hong Miao, Jing-Kang Shen, Jian Ding, Yi Chen, Lin-Jiang Tong, Lan-Ping Ma, Xia-Juan Huan, Jun-Mei Yi, Tao Meng, Ying-Qing Wang, Wei Wang
Colchicine site–targeted tubulin inhibitors are a promising type of anticancer drugs. MT189 is a new derivative of MT119, a previously reported colchicine site–binding antitubulin agent. In this study, MT189 was demonstrated to retain the propert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46801cd2710063bef7c66d16d65c4bec
https://doi.org/10.1158/1535-7163.c.6536575.v1
https://doi.org/10.1158/1535-7163.c.6536575.v1
Autor:
Ze-Hong Miao, Jing-Kang Shen, Jian Ding, Yi Chen, Lin-Jiang Tong, Lan-Ping Ma, Xia-Juan Huan, Jun-Mei Yi, Tao Meng, Ying-Qing Wang, Wei Wang
PDF - 636K, Whether MT189 induces the colocalization of JNK or p-JNK with α-tubulin was examined by confocal microscopy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29c794a864158c6378f9f1aaca4a9c7e
https://doi.org/10.1158/1535-7163.22500787.v1
https://doi.org/10.1158/1535-7163.22500787.v1
Autor:
Ze-Hong Miao, Jing-Kang Shen, Jian Ding, Yi Chen, Lin-Jiang Tong, Lan-Ping Ma, Xia-Juan Huan, Jun-Mei Yi, Tao Meng, Ying-Qing Wang, Wei Wang
PDF - 18K, The chemical structure of MT189 and its synthesis approach.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05dcdb91fed02d06c9531dcb1bad5520
https://doi.org/10.1158/1535-7163.22500805
https://doi.org/10.1158/1535-7163.22500805
Autor:
Ze-Hong Miao, Jing-Kang Shen, Jian Ding, Yi Chen, Lin-Jiang Tong, Lan-Ping Ma, Xia-Juan Huan, Jun-Mei Yi, Tao Meng, Ying-Qing Wang, Wei Wang
PDF - 21K, MT189 displays an enhanced in vitro proliferation-inhibitory activity when compared with its parental compound MT119.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2690fde3aaf695daa91cbfa8d36aa9e6
https://doi.org/10.1158/1535-7163.22500802.v1
https://doi.org/10.1158/1535-7163.22500802.v1