Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jing-Dong Jackie Han"'
Publikováno v:
The Lancet Regional Health. Western Pacific, Vol 37, Iss , Pp 100858- (2023)
Externí odkaz:
https://doaj.org/article/e1ab94f32a0c455691b3b8d111207a84
Autor:
Zhen Qi, Yehua Li, Bing Zhao, Chi Xu, Yuan Liu, Haonan Li, Bingjie Zhang, Xinquan Wang, Xiao Yang, Wei Xie, Baojie Li, Jing-Dong Jackie Han, Ye-Guang Chen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Bone morphogenetic protein (BMP) maintains intestinal homeostasis by restricting its hyperproliferation but whether it directly regulates the stem cells is unknown. Here the authors show that BMP constrains the Lgr5+stem cell expansion under both hom
Externí odkaz:
https://doaj.org/article/1cfafbf39370423c97491755711f11d9
Autor:
Chi Xu, Daosheng Ai, Shengbao Suo, Xingwei Chen, Yizhen Yan, Yaqiang Cao, Na Sun, Weizhong Chen, Joseph McDermott, Shiqiang Zhang, Yingying Zeng, Jing-Dong Jackie Han
Publikováno v:
Cell Reports, Vol 25, Iss 2, Pp 523-535.e5 (2018)
Summary: Experimental large-scale screens for drug repositioning are limited by restriction to in vitro conditions and lack of applicability to real human conditions. Here, we developed an in silico screen in human in vivo conditions using a referenc
Externí odkaz:
https://doaj.org/article/37edbf8449584e26af217aee174af965
Publikováno v:
F1000Research, Vol 6 (2017)
Individuals of the same age may not age at the same rate. Quantitative biomarkers of aging are valuable tools to measure physiological age, assess the extent of ‘healthy aging’, and potentially predict health span and life span for an individual.
Externí odkaz:
https://doaj.org/article/4a46eac440424c12b20d71c1811bc4d4
Autor:
Lyad Zamir, Reena Singh, Elisha Nathan, Ralph Patrick, Oren Yifa, Yfat Yahalom-Ronen, Alaa A Arraf, Thomas M Schultheiss, Shengbao Suo, Jing-Dong Jackie Han, Guangdun Peng, Naihe Jing, Yuliang Wang, Nathan Palpant, Patrick PL Tam, Richard P Harvey, Eldad Tzahor
Publikováno v:
eLife, Vol 6 (2017)
Novel regenerative therapies may stem from deeper understanding of the mechanisms governing cardiovascular lineage diversification. Using enhancer mapping and live imaging in avian embryos, and genetic lineage tracing in mice, we investigated the spa
Externí odkaz:
https://doaj.org/article/91a9da3c78ca4d5aac16920103726488
Publikováno v:
Genomics Data, Vol 5, Iss C, Pp 375-377 (2015)
Appropriate neural initiation of the pluripotent stem cells in the early embryos is critical for the development of the central nervous system. This process is regulated by the coordination of extrinsic signals and intrinsic programs. However, how th
Externí odkaz:
https://doaj.org/article/2c9a90987eaf4d07b5c2f1fe37116ca1
Publikováno v:
Cell Reports, Vol 4, Iss 3, Pp 542-553 (2013)
Ovarian cancer has a poor prognosis, with different outcomes for different patients. The mechanism underlying this poor prognosis and heterogeneity is not well understood. We have developed an unbiased, adaptive clustering approach to integratively a
Externí odkaz:
https://doaj.org/article/9a719db7300c4c6e8ac5877a490f31f5
Autor:
Qingqing Zhu, Lu Song, Guangdun Peng, Na Sun, Jun Chen, Ting Zhang, Nengyin Sheng, Wei Tang, Cheng Qian, Yunbo Qiao, Ke Tang, Jing-Dong Jackie Han, Jinsong Li, Naihe Jing
Publikováno v:
eLife, Vol 3 (2014)
The neural fate commitment of pluripotent stem cells requires the repression of extrinsic inhibitory signals and the activation of intrinsic positive transcription factors. However, how these two events are integrated to ensure appropriate neural con
Externí odkaz:
https://doaj.org/article/41b05fe34676495fa3fa0b7a33ff13ac
Publikováno v:
Genomics Data, Vol 5, Iss C, Pp 15-16 (2015)
Epigenetic modification as an intrinsic fine-tune program cooperates with key transcription factors to regulate the cell fate determination. The histone acetylation participating in neural differentiation of pluripotent stem cells is expected but not
Externí odkaz:
https://doaj.org/article/5bacf45d1b054a72a0d38488635cdba6
Autor:
Clayton E Friedman, Quan Nguyen, Samuel W Lukowski, Han Sheng Chiu, Abbigail Helfer, Jason Miklas, Shengbao Suo Suo, Jing-Dong Jackie Han, Pierre Osteil, Guangdun Peng, Naihe Jing, Greg J Baillie, Anne Senabouth, Angelika N Christ, Timothy J Bruxner, Charles E Murry, Emily S Wong, Jun Ding, Yuliang Wang, James Hudson, Hannele Ruohola-Baker, Ziv Bar-Joseph, Patrick P L Tam, Joseph E Powell, Nathan J Palpant
Differentiation into diverse cell lineages requires the orchestration of gene regulatory networks guiding diverse cell fate choices. Utilizing human pluripotent stem cells, we measured expression dynamics of 17,718 genes from 43,168 cells across five
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b015ad971c0b6834570f4c0c3ac71a7d
https://doi.org/10.1101/229294
https://doi.org/10.1101/229294
