Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Jing-Chun Han"'
Publikováno v:
Chemical Reviews. 123:4934-4971
Publikováno v:
Tetrahedron. 75:1739-1745
The collective total synthesis of a series of botryanes, which are an important group of sesquiterpene antibiotics isolated from the metabolites of the fungus Botrytis cinerea, has been reported. The highly functionalized hydrindane skeleton of the b
Publikováno v:
Chemical reviews. 120(13)
Natural products containing eight-membered carbocycles constitute a class of structurally intriguing and biologically important molecules such as the famous diterpenes taxol and vinigrol. Such natural products are being increasingly investigated beca
Publikováno v:
Tetrahedron. 73:3289-3303
The humulanolides are a series of sesquiterpene lactones, most of which have unique and challenging structure. The humulanolides have exhibited anticancer activity. The combinations of fascinating structural motifs and promising pharmacological prope
Publikováno v:
Tetrahedron. 73:3629-3635
A concise approach for the stereoselective construction of the oxa-pentacyclic core of solanoeclepin A has been developed by using the intramolecular Diels-Alder (IMDA) reaction from the furan-tethered dienophile.
Autor:
Jing-Chun Han, Chuang-Chuang Li
Publikováno v:
The Chemical Record. 17:499-517
In this account, we provide a brief summary of recent developments in ruthenium-catalyzed metathesis cascade reactions towards the total synthesis of natural products. We also highlight recent progress from our own laboratory regarding the synthesis
Publikováno v:
Organic Letters. 18:4932-4935
The first and catalytic enantioselective total synthesis of hypocrolide A (>99% ee) in 12 steps, as well as other botryanes, is described. The absolute configurations of these compounds have been unambiguously confirmed or reassigned accordingly. The
Autor:
Jing-Chun Han, Chuang-Chuang Li
Publikováno v:
Synlett. 26:1289-1304
This account describes our laboratory’s latest endeavors toward the collective synthesis of natural products. An overview of the general strategy is presented together with several total syntheses developed by our group. These examples demonstrate
Publikováno v:
Journal of the American Chemical Society. 136:13610-13613
A new method has been developed for the concise and asymmetric synthesis of seven humulanolides in 5-7 steps without the need for protecting groups. Notably, the challenging 11-membered ring and bridged butenolide moieties in asteriscunolide D and 6,
Publikováno v:
Phytotherapy Research. 28:1577-1580
The present study aims to investigate the influence of irinotecan's toxicity by the biotransformation of glucoaurantio-obtusin to aurantio-obtusin. Intraperitoneal administration (i.p.) of 100 mg/kg aurantio-obtusin significantly increased the toxici