Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Jing Yuan Chooi"'
Autor:
Phyllis S.Y. Chong, Jing Yuan Chooi, Sze Lynn Julia Lim, Tae-Hoon Chung, Reinhard Brunmeir, Aaron Chung Yong Leow, Sabrina Hui Min Toh, Kalpnaa Balan, Muhamad Irfan Bin Azaman, Zhengwei Wu, Nagavidya Subramaniam, Leah A Vardy, Wee-Joo Chng
Publikováno v:
Haematologica, Vol 109, Iss 6 (2023)
REIIBP is a lysine methyltransferase aberrantly expressed through alternative promoter usage of NSD2 locus in t(4;14)-translocated multiple myeloma (MM). Clinically, t(4;14) translocation is an adverse prognostic factor found in approximately 15% of
Externí odkaz:
https://doaj.org/article/f19e38c9080845be90a8baff6bb37aa2
Autor:
Jennifer Yang, Anand D Jeyasekharan, Joanne Lee, Wee Joo Chng, Tae-Hoon Chung, Nurulhuda Mustafa, Adina Huey Fang Nee, Jing Yuan Chooi, Sabrina Hui Min Toh, Viknesvaran Selvarajan, Shuangyi Fan, Siok Bian Ng, Michelle Poon, Esther Chan, Yen Lin Chee, Longen Zhou
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 7 (2021)
Background The potential therapeutic efficacy of daratumumab in natural killer T-cell lymphoma (NKTL) was highlighted when its off-label usage produced sustained remission in a patient with highly refractory disease. This is corroborated recently by
Externí odkaz:
https://doaj.org/article/9c459924e2a046e6b5b7572c0f5ce51a
Autor:
Chelsia Qiuxia Wang, Vaidehi Krishnan, Lavina Sierra Tay, Desmond Wai Loon Chin, Cai Ping Koh, Jing Yuan Chooi, Giselle Sek Suan Nah, Linsen Du, Bindya Jacob, Namiko Yamashita, Soak Kuan Lai, Tuan Zea Tan, Seiichi Mori, Ichiro Tanuichi, Vinay Tergaonkar, Yoshiaki Ito, Motomi Osato
Publikováno v:
Cell Reports, Vol 8, Iss 3, Pp 767-782 (2014)
The RUNX genes encode transcription factors involved in development and human disease. RUNX1 and RUNX3 are frequently associated with leukemias, yet the basis for their involvement in leukemogenesis is not fully understood. Here, we show that Runx1;R
Externí odkaz:
https://doaj.org/article/3b353b3acf3041a084d54e3e7b53c5e3
Autor:
Wee Joo Chng, Peng Shen, Zhen Cai, Enfan Zhang, Julia S.L. Lim, Regina W.J. Wong, Kalpnaa Balan, Sabrina H.M. Toh, Sinan Xiong, Melissa J. Fullwood, Takaomi Sanda, Jing-Yuan Chooi, Yongxia Chen, Tae-Hoon Chung, Tze King Tan, Jianbiao Zhou, Yunlu Jia
Supplementary Table 5 shows the results of NSD2-MASPEC in KMS11 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e797f1d67ab8cec780c618567024158
https://doi.org/10.1158/0008-5472.22582469.v1
https://doi.org/10.1158/0008-5472.22582469.v1
Autor:
Wee Joo Chng, Peng Shen, Zhen Cai, Enfan Zhang, Julia S.L. Lim, Regina W.J. Wong, Kalpnaa Balan, Sabrina H.M. Toh, Sinan Xiong, Melissa J. Fullwood, Takaomi Sanda, Jing-Yuan Chooi, Yongxia Chen, Tae-Hoon Chung, Tze King Tan, Jianbiao Zhou, Yunlu Jia
Supplementary Table 2 shows 26 SE-associated genes commonly acquired in both t(4:14)-positive HMCLs and patient-derived MM sample.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f0c38237d54f425ea7a835560a97bf
https://doi.org/10.1158/0008-5472.22582478.v1
https://doi.org/10.1158/0008-5472.22582478.v1
Autor:
Wee Joo Chng, Peng Shen, Zhen Cai, Enfan Zhang, Julia S.L. Lim, Regina W.J. Wong, Kalpnaa Balan, Sabrina H.M. Toh, Sinan Xiong, Melissa J. Fullwood, Takaomi Sanda, Jing-Yuan Chooi, Yongxia Chen, Tae-Hoon Chung, Tze King Tan, Jianbiao Zhou, Yunlu Jia
Multiple myeloma is an incurable malignancy with marked clinical and genetic heterogeneity. The cytogenetic abnormality t(4;14) (p16.3;q32.3) confers aggressive behavior in multiple myeloma. Recently, essential oncogenic drivers in a wide range of ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b5eab75f94cc27a2891d51f2f231028
https://doi.org/10.1158/0008-5472.c.6570596
https://doi.org/10.1158/0008-5472.c.6570596
Autor:
Wee Joo Chng, Peng Shen, Zhen Cai, Enfan Zhang, Julia S.L. Lim, Regina W.J. Wong, Kalpnaa Balan, Sabrina H.M. Toh, Sinan Xiong, Melissa J. Fullwood, Takaomi Sanda, Jing-Yuan Chooi, Yongxia Chen, Tae-Hoon Chung, Tze King Tan, Jianbiao Zhou, Yunlu Jia
Supplementary Table 3 Uni- and multivariate Cox survival analysis using HJURP and NSD2 expression in myeloma dataset
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76952ffde2ec93347943fa1cd254a3b1
https://doi.org/10.1158/0008-5472.22582475.v1
https://doi.org/10.1158/0008-5472.22582475.v1
Autor:
Wee-Joo Chng, Qi Zeng, Shi Wang, Siok-Bian Ng, Chin Hin Ng, Tuan Zea Tan, Motomi Osato, Yafeng Zhou, Ying Qing Ching, Shaw-Cheng Liu, Lip-Lee Cheong, Jing-Yuan Chooi, Phyllis S.Y. Chong, Xiao Lu, Chonglei Bi, Zit-Liang Chan, Jianbiao Zhou
This file contains additional Methods and Results. S1. Real-time quantitative RT-PCR (qRT-PCR) validation of expression levels of some selected genes from microarray study (n = 3, mean {plus minus}SD). S2. Functional networks were generated by MetaCo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd777e82b8f4b900439440e124bd0534
https://doi.org/10.1158/1541-7786.22512106
https://doi.org/10.1158/1541-7786.22512106
Autor:
Wee-Joo Chng, Michael Sebag, Daniel D. Waller, Qi Zeng, Zea Tuan Tan, Tae-Hoon Chung, Jing-Yuan Chooi, Yan Ting Hee, Julia S.L. Lim, Jianbiao Zhou, Phyllis S.Y. Chong
Table S1: RT-PCR primers Figure S1: mRNA and protein expression of PRL-3 in HMCLs. Figure S2. IL-6 treatment of MM cell lines. Figure S3. Cellular effects of PRL-3 knockdown in HMCLs. Figure S4. Treatment of BTZ-resistant cells with PRL-3 inhibitor I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e934dc13d07109ecfabbd698dd1cd4
https://doi.org/10.1158/0008-5472.22421531
https://doi.org/10.1158/0008-5472.22421531
Autor:
Wee-Joo Chng, Michael Sebag, Daniel D. Waller, Qi Zeng, Zea Tuan Tan, Tae-Hoon Chung, Jing-Yuan Chooi, Yan Ting Hee, Julia S.L. Lim, Jianbiao Zhou, Phyllis S.Y. Chong
Overexpression of PRL-3, an oncogenic phosphatase, was identified as a novel cluster in patients with newly diagnosed multiple myeloma. However, the regulation and oncogenic activities of PRL-3 in multiple myeloma warrant further investigation. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31066edb2b06953929b10ec839abaea9
https://doi.org/10.1158/0008-5472.c.6510956
https://doi.org/10.1158/0008-5472.c.6510956