Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Jing Yuan Chooi"'
Autor:
Phyllis S.Y. Chong, Jing Yuan Chooi, Sze Lynn Julia Lim, Tae-Hoon Chung, Reinhard Brunmeir, Aaron Chung Yong Leow, Sabrina Hui Min Toh, Kalpnaa Balan, Muhamad Irfan Bin Azaman, Zhengwei Wu, Nagavidya Subramaniam, Leah A Vardy, Wee-Joo Chng
Publikováno v:
Haematologica, Vol 109, Iss 6 (2023)
REIIBP is a lysine methyltransferase aberrantly expressed through alternative promoter usage of NSD2 locus in t(4;14)-translocated multiple myeloma (MM). Clinically, t(4;14) translocation is an adverse prognostic factor found in approximately 15% of
Externí odkaz:
https://doaj.org/article/f19e38c9080845be90a8baff6bb37aa2
Autor:
Yunlu Jia, Jianbiao Zhou, Tze King Tan, Tae-Hoon Chung, Regina Wan Ju Wong, Jing-Yuan Chooi, Julia Sze Lynn Lim, Takaomi Sanda, Melissa Ooi, Sanjay De Mel, Cinnie Soekojo, Yongxia Chen, Enfan Zhang, Zhen Cai, Peng Shen, Jian Ruan, Wee-Joo Chng
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 2, Pp 1-13 (2021)
Abstract Multiple myeloma (MM) is an aggressive plasma cell neoplasm characterized by genomic heterogeneity. Superenhancers (SEs) are defined as large clusters of enhancers in close genomic proximity, which regulate genes for maintaining cellular ide
Externí odkaz:
https://doaj.org/article/84a9518ee10c44cc91668e7428907d28
Autor:
Jennifer Yang, Anand D Jeyasekharan, Joanne Lee, Wee Joo Chng, Tae-Hoon Chung, Nurulhuda Mustafa, Adina Huey Fang Nee, Jing Yuan Chooi, Sabrina Hui Min Toh, Viknesvaran Selvarajan, Shuangyi Fan, Siok Bian Ng, Michelle Poon, Esther Chan, Yen Lin Chee, Longen Zhou
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 7 (2021)
Background The potential therapeutic efficacy of daratumumab in natural killer T-cell lymphoma (NKTL) was highlighted when its off-label usage produced sustained remission in a patient with highly refractory disease. This is corroborated recently by
Externí odkaz:
https://doaj.org/article/9c459924e2a046e6b5b7572c0f5ce51a
Autor:
Jianbiao Zhou, Sabrina Hui-Min Toh, Zit-Liang Chan, Jessie Yiying Quah, Jing-Yuan Chooi, Tuan Zea Tan, Phyllis S. Y. Chong, Qi Zeng, Wee-Joo Chng
Publikováno v:
Journal of Hematology & Oncology, Vol 11, Iss 1, Pp 1-12 (2018)
Abstract Background Protein tyrosine phosphatase of regenerating liver 3 (PRL-3) is overexpressed in a subset of AML patients with inferior prognosis, representing an attractive therapeutic target. However, due to relatively shallow pocket of the cat
Externí odkaz:
https://doaj.org/article/57ddfe36df5c4d61aa3ae49750543f97
Autor:
Jianbiao Zhou, Chonglei Bi, Ying Qing Ching, Jing-Yuan Chooi, Xiao Lu, Jessie Yiying Quah, Sabrina Hui-Min Toh, Zit-Liang Chan, Tuan Zea Tan, Phyllis SY Chong, Wee-Joo Chng
Publikováno v:
Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-13 (2017)
Abstract Background Current conventional chemotherapy for acute myeloid leukemia (AML) can achieve remission in over 70% of patients, but a majority of them will relapse within 5 years despite continued treatment. The relapse is postulated to be due
Externí odkaz:
https://doaj.org/article/bb8e3cff02414ed78cf8acad3518d8be
Autor:
Jianbiao Zhou, Jessie Yiying Quah, Yvonne Ng, Jing-Yuan Chooi, Sabrina Hui-Min Toh, Baohong Lin, Tuan Zea Tan, Hiroki Hosoi, Motomi Osato, Qihui Seet, A.G. Lisa Ooi, Bertil Lindmark, Mark McHale, Wee-Joo Chng
Publikováno v:
Haematologica, Vol 105, Iss 9 (2019)
Differentiation therapies achieve remarkable success in acute promyelocytic leukemia, a subtype of acute myeloid leukemia. However, excluding acute promyelocytic leukemia, clinical benefits of differentiation therapies are negligible in acute myeloid
Externí odkaz:
https://doaj.org/article/56ad0bec66f3412784863e98d8cdb0c7
Autor:
Wee Joo Chng, Peng Shen, Zhen Cai, Enfan Zhang, Julia S.L. Lim, Regina W.J. Wong, Kalpnaa Balan, Sabrina H.M. Toh, Sinan Xiong, Melissa J. Fullwood, Takaomi Sanda, Jing-Yuan Chooi, Yongxia Chen, Tae-Hoon Chung, Tze King Tan, Jianbiao Zhou, Yunlu Jia
Supplementary Table 5 shows the results of NSD2-MASPEC in KMS11 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e797f1d67ab8cec780c618567024158
https://doi.org/10.1158/0008-5472.22582469.v1
https://doi.org/10.1158/0008-5472.22582469.v1
Autor:
Wee Joo Chng, Peng Shen, Zhen Cai, Enfan Zhang, Julia S.L. Lim, Regina W.J. Wong, Kalpnaa Balan, Sabrina H.M. Toh, Sinan Xiong, Melissa J. Fullwood, Takaomi Sanda, Jing-Yuan Chooi, Yongxia Chen, Tae-Hoon Chung, Tze King Tan, Jianbiao Zhou, Yunlu Jia
Supplementary Table 2 shows 26 SE-associated genes commonly acquired in both t(4:14)-positive HMCLs and patient-derived MM sample.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f0c38237d54f425ea7a835560a97bf
https://doi.org/10.1158/0008-5472.22582478.v1
https://doi.org/10.1158/0008-5472.22582478.v1
Autor:
Wee Joo Chng, Peng Shen, Zhen Cai, Enfan Zhang, Julia S.L. Lim, Regina W.J. Wong, Kalpnaa Balan, Sabrina H.M. Toh, Sinan Xiong, Melissa J. Fullwood, Takaomi Sanda, Jing-Yuan Chooi, Yongxia Chen, Tae-Hoon Chung, Tze King Tan, Jianbiao Zhou, Yunlu Jia
Multiple myeloma is an incurable malignancy with marked clinical and genetic heterogeneity. The cytogenetic abnormality t(4;14) (p16.3;q32.3) confers aggressive behavior in multiple myeloma. Recently, essential oncogenic drivers in a wide range of ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b5eab75f94cc27a2891d51f2f231028
https://doi.org/10.1158/0008-5472.c.6570596
https://doi.org/10.1158/0008-5472.c.6570596
Autor:
Wee Joo Chng, Peng Shen, Zhen Cai, Enfan Zhang, Julia S.L. Lim, Regina W.J. Wong, Kalpnaa Balan, Sabrina H.M. Toh, Sinan Xiong, Melissa J. Fullwood, Takaomi Sanda, Jing-Yuan Chooi, Yongxia Chen, Tae-Hoon Chung, Tze King Tan, Jianbiao Zhou, Yunlu Jia
Supplementary Table 3 Uni- and multivariate Cox survival analysis using HJURP and NSD2 expression in myeloma dataset
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76952ffde2ec93347943fa1cd254a3b1
https://doi.org/10.1158/0008-5472.22582475.v1
https://doi.org/10.1158/0008-5472.22582475.v1