Inhibition of TAF1B impairs ribosome biosynthesis and suppresses cell proliferation in stomach adenocarcinoma through promoting c-MYC mRNA degradation

Autor: Hang-fei Chen, Zhang-ping Li, Qi Wu, Chun Yu, Jing-Yi Yan, Yong-feng Bai, Sheng-mei Zhu, Mao-xiang Qian, Ming Liu, Li-feng Xu, Zheng Peng, Feng Zhang

Publikováno v: Heliyon, Vol 10, Iss 1, Pp e23167- (2024)

Hyperactivation of ribosome biosynthesis (RiBi) is a hallmark of cancer, and targeting ribosome biogenesis has emerged as a potential therapeutic strategy. The depletion of TAF1B, a major component of selectivity factor 1 (SL1), disrupts the pre-init

Externí odkaz: https://doaj.org/article/f6a9d51cd35f4ccbbcdca3ba33e96da1

Global leadership initiative in malnutrition (GLIM) criteria using hand-grip strength adequately predicts postoperative complications and long-term survival in patients underwent radical gastrectomy for gastric cancer

Autor: Dong-Dong Huang, Ding-Ye Yu, Wen-Bin Wang, Hao-Nan Song, Xin Luo, Gao-Feng Wu, Xiao-Lei Chen, Zhen Yu, Jing-Yi Yan

Publikováno v: European Journal of Clinical Nutrition. 76:1323-1331

The present study aims to investigate whether malnutrition defined by the Global Leadership Initiative in Malnutrition (GLIM) criteria using hand-grip strength (HGS) adequately predict postoperative complications and long-term survival in patients un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbb68aa36837285ddd441733698ed091
https://doi.org/10.1038/s41430-022-01109-2

Nrf2 deficiency promotes the increasing trend of autophagy during aging in skeletal muscle: a potential mechanism for the development of sarcopenia

Autor: Qian-Tong Dong, Sheng-Dong Fan, Jing-Yi Yan, Huang Dongdong, Na-Xin Liu, Xiao-Lei Chen, Wei-Zhe Chen, Zhen Yu, Xia-Lin Yan, Xi-Yi Chen

Publikováno v: Aging (Albany NY)

This study aims to explore the impact of nuclear factor erythroid 2-related factor 2 (Nrf2) deficiency on skeletal muscle autophagy and the development of sarcopenia. LC3b, P62, Bnip3, Lamp-1, and AMPK protein levels were measured in muscle from youn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::735e774b9cf6f7c47b79d1063360fa24
https://doi.org/10.18632/aging.102990

Value of Sarcopenia defined by the new EWGSOP2 consensus for the prediction of Postoperative Complications and Long-term Survival after Radical Gastrectomy for Gastric Cancer: A comparison with four common nutritional screening tools

Autor: Qian-Tong Dong, Dong-Dong Huang, Xiao-Lei Chen, Jing-Yi Yan, Xi-Yi Chen, Wen-Xi Dong, Hui-Yang Cai, Drugyel Wangchuk

Publikováno v: Journal of Cancer

Background: Nutritional risk and sarcopenia are both associated with increased postoperative morbidity and mortality following elective surgery. This study aimed to investigate whether sarcopenia has additional predictive value for postoperative comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b8f05ba6f92798684ddfdbb6744e1fe
https://pubmed.ncbi.nlm.nih.gov/32913478

Downregulation of lncRNA CCDC26 contributes to imatinib resistance in human gastrointestinal stromal tumors through IGF-1R upregulation

Autor: Changyuan Hu, Xuecheng Sun, Qian-Tong Dong, Jing-Yi Yan, Feng Zhou, Wei Chen, Didi Chen, Xiaolei Chen

Publikováno v: Brazilian Journal of Medical and Biological Research, Volume: 52, Issue: 6, Article number: e8399, Published: 03 JUN 2019
Brazilian Journal of Medical and Biological Research
Brazilian Journal of Medical and Biological Research v.52 n.6 2019
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
Brazilian Journal of Medical and Biological Research, Vol 52, Iss 6

Imatinib is the first line of therapy for patients with metastatic or gastrointestinal stromal tumors (GIST). However, drug resistance limits the long-term effect of imatinib. Long non-coding RNAs (lncRNAs) are emerging as key players in regulating d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a494c54560fdc799d02a3e30a31ae0a8
https://doi.org/10.1590/1414-431x20198399