Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jing W. Zhu"'
Publikováno v:
Genes and Diseases, Vol 8, Iss 2, Pp 224-231 (2021)
Genes & Diseases
Genes & Diseases
The incidence of haemoglobinopathy is high in China, especially south of the Yangtze River. However, the exact status of haemoglobinopathy in Sichuan is unknown. To carry out a detailed research of haemoglobinopathy in individuals living in Sichuan,
Autor:
Yanli Yang, Sherry H. Yeh, Shravan Madireddi, Wadim L. Matochko, Chen Gu, Patricia Pacheco Sanchez, Mark Ultsch, Gladys De Leon Boenig, Seth F. Harris, Brandon Leonard, Suzie J. Scales, Jing W. Zhu, Erin Christensen, Julie Q. Hang, Randall J. Brezski, Scot Marsters, Avi Ashkenazi, Siddharth Sukumaran, Henry Chiu, Rafael Cubas, Jeong M. Kim, Greg A. Lazar
Publikováno v:
mAbs
Agonism of members of the tumor necrosis factor receptor superfamily (TNFRSF) with monoclonal antibodies is of high therapeutic interest due to their role in immune regulation and cell proliferation. A major hurdle for pharmacologic activation of thi
Publikováno v:
PLoS Pathogens, Vol 5, Iss 7, p e1000501 (2009)
Delivery of effector proteins is a process widely used by bacterial pathogens to subvert host cell functions and cause disease. Effector delivery is achieved by elaborate injection devices and can often be triggered by environmental stimuli. However,
Externí odkaz:
https://doaj.org/article/c2fb3b75d8864413b3670cb4e066a45a
Publikováno v:
Immunity, vol 45, iss 6
B1 and B2 B cells differ in their ability to respond to T-cell-independent (TI) antigens. Here we report that the Src-family kinase (SFK) regulator CD148 has a unique and critical role in the initiation of B1 but not B2 cell antigen receptor signalin
Autor:
Kristin Doan, Jing W. Zhu, Arthur Weiss, Jason Park, Angela H. Chau, Hong Zhang, Clifford A. Lowell
Publikováno v:
Immunity. 35:757-769
SummaryNeutrophils, critical innate immune effectors, use bacterial-derived chemoattractant-induced G protein-coupled receptor (GPCR) signaling for their pursuit of bacteria. Tyrosine phosphorylation pathways and receptor-like tyrosine phosphatases (
Publikováno v:
Immunological Reviews. 228:288-311
Reciprocal regulation of tyrosine phosphorylation by protein tyrosine kinases and phosphatases is central to normal immune cell function. Disruption of the equilibrium between protein tyrosine kinase and phosphatase activity can result in immunodefic
Publikováno v:
Immunity. 28(2):183-196
SummaryThe receptor-type protein tyrosine phosphatase (RPTP) CD148 is thought to have an inhibitory function in signaling and proliferation in nonhematopoietic cells. However, its role in the immune system has not been thoroughly studied. Our analysi
Autor:
Christopher J. Hogan, Jing W. Zhu, Jeffery S. Tessem, Joshua Beilke, Jan Jensen, James DeGregori, Marileila Varella-Garcia, Feng X. Li
Publikováno v:
Proceedings of the National Academy of Sciences. 100:12935-12940
Our studies of mice deficient for the E2F1 and E2F2 transcription factors have revealed essential roles for these proteins in the cell cycle control of pancreatic exocrine cells and the regulation of pancreatic beta cell maintenance. Pancreatic exocr
Publikováno v:
Molecular and Cellular Biology. 23:3607-3622
E2F plays critical roles in cell cycle progression by regulating the expression of genes involved in nucleotide synthesis, DNA replication, and cell cycle control. We show that the combined loss of E2F1 and E2F2 in mice leads to profound cell-autonom
Autor:
Tamiko R. Katsumoto, Makoto Kudo, Dean Sheppard, Elliott C. Callahan, Chun Chen, Connor E. Rosen, Boryana N. Manz, Jing W. Zhu, Arthur Weiss, Jae Won Lee, Joseph Lin, Xiaozhu Huang, Aparna Sundaram, Michael A. Matthay
Publikováno v:
The Journal of clinical investigation, vol 123, iss 5
Katsumoto, TR; Kudo, M; Chen, C; Sundaram, A; Callahan, EC; Zhu, JW; et al.(2013). The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases. Journal of Clinical Investigation, 123(5), 2037-2048. doi: 10.1172/JCI66397. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/0j10d9pr
Katsumoto, TR; Kudo, M; Chen, C; Sundaram, A; Callahan, EC; Zhu, JW; et al.(2013). The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases. Journal of Clinical Investigation, 123(5), 2037-2048. doi: 10.1172/JCI66397. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/0j10d9pr
Increased airway smooth muscle (ASM) contractility and the development of airway hyperresponsiveness (AHR) are cardinal features of asthma, but the signaling pathways that promote these changes are poorly understood. Tyrosine phosphorylation is tight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::640ec4966fe7c5f946d234dd9a8aadfa
https://escholarship.org/uc/item/0j10d9pr
https://escholarship.org/uc/item/0j10d9pr