Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jing Sheng Zheng"'
Autor:
Jing-Sheng Zheng, Xilin Long, Michael T. Crow, Marvin O. Boluyt, Lydia O'Neill, W. J. Lederer, Yanshan Dai, Zhihe Li, Jun Li, Edward G. Lakatta, Bruce J. Baum, Heping Cheng
Publikováno v:
The Asia Pacific Heart Journal. 8:36-43
Background. AQP-1, a channel-forming integral membrane protein of 28 kDa prevalent in red blood cells and renal proximal tubules, was recently shown to be expressed in rat heart. Aims : Our purpose was to charaterise the experssion of the AQO-1 gene
Autor:
Marvin O. Boluyt, Jing Sheng Zheng, Edward G. Lakatta, Lydia O'Neill, Guimei Wu, Xilin Long, Michael T. Crow, Yu Ko Nitta
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 54:B23-B27
Although previous studies have shown that cardiac myosin heavy chain (MHC) composition undergoes a switch from the alpha- to beta-isoform in the heart during adult aging, the underlying mechanisms responsible for this switch are unknown. Cardiac MHC
Autor:
Marvin O. Boluyt, Edward G. Lakatta, Tania E. Webb, Lydia O'Neill, Eric A. Barnard, Jing Sheng Zheng, Xilin Long
Publikováno v:
Cardiovascular Research. 37:718-728
Objectives: The aims of this study were to determine (1) whether neonatal rat cardiac fibroblasts (CAFB) express P2Y receptors; (2) whether CAFB respond to extracellular ATP by inducing expression of c-fos mRNA; and (3) whether extracellular ATP modu
Autor:
Antoine Younes, Howard S. Silverman, Jing Sheng Zheng, Michael T. Crow, Lydia O'Neill, Xilin Long, Marvin O. Boluyt, Edward G. Lakatta
Publikováno v:
Circulation Research. 81:176-186
Abstract The 70-kD S6 kinase (p70 S6K ) has been implicated in the regulation of protein synthesis in many cell types and in the angiotensin II–stimulated hypertrophy of cardiac myocytes. Our purpose was to determine whether p70 S6K plays a role in
Autor:
Edward G. Lakatta, Maria De Lourdes Hipolito, Marvin O. Boluyt, Jing Sheng Zheng, Lydia O'Neill, Martha S. Lundberg, Corrado Cirielli, Xilin Long, Michael T. Crow
Publikováno v:
Journal of Clinical Investigation. 99:2635-2643
Myocyte cell loss is a prominent and important pathogenic feature of cardiac ischemia. We have used cultured neonatal rat cardiac myocytes exposed to prolonged hypoxia as an experimental system to identify critical factors involved in cardiomyocyte d
Publikováno v:
Annals of the New York Academy of Sciences. 603:448-451
Autor:
Jing Sheng Zheng, Xilin Long, Marvin O. Boluyt, Michael T. Crow, Edward G. Lakatta, Lydia O'Neill
Publikováno v:
Circulation research. 78(4)
Abstract We have previously shown that extracellular ATP, like norepinephrine (NE) and many other hypertrophyinducing agents, increases expression of the immediate-early genes c- fos and junB in cultured neonatal cardiac myocytes but that the intrace
Publikováno v:
Circulation research. 74(6)
It is well-documented that norepinephrine (NE) induces the expression of immediate-early genes (IEGs), such as c-fos, c-jun, and jun-B, in cultured neonatal heart cells and leads to cell growth without cell division (ie, hypertrophy). Although purine
Ca2+ mobilization by extracellular ATP in rat cardiac myocytes: regulation by protein kinase C and A
Publikováno v:
The American journal of physiology. 263(5 Pt 1)
Activation of protein kinase C (PKC) modulates the mobilization of intracellular Ca2+ induced by extracellular ATP in rat ventricular myocytes. Pretreatment of myocytes with PKC activators attenuated both the ATP-induced Ca2+ transient and the noradr
Publikováno v:
The American journal of physiology. 262(1 Pt 1)
ATP transiently increases the intracellular Ca2+ concentration in cardiac myocyte suspensions. Pretreatment with norepinephrine (NE) greatly potentiates the ATP response. We performed experiments on adult rat myocyte suspensions loaded with fura-2 to