Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Jing Ru Weng"'
Autor:
Kai-Cheng Hsu, Yun-Yi Huang, Jung-Chun Chu, Yu-Wen Huang, Jing-Lan Hu, Tony Eight Lin, Shih-Chung Yen, Jing-Ru Weng, Wei-Jan Huang
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
Class IIa histone deacetylases (HDACs) have been linked to tumorigenesis in various cancers. Previously, we designed phenylhydroxamic acid LH4f as a potent class IIa HDAC inhibitor. However, it also unselectively inhibited class I and class IIb HDACs
Externí odkaz:
https://doaj.org/article/2d0d3d594369440e9a61c2c583b064c2
Autor:
Jing-Ru Weng, Li-Yuan Bai, Shih-Jiuan Chiu, Chang-Fang Chiu, Wei-Yu Lin, Jing-Lan Hu, Tzong-Ming Shieh
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 17, Iss , Pp 151-159 (2019)
Cardiac glycosides (CGs), prescribed to treat congestive heart failure and arrhythmias, exert potent antitumor activity. In this study, divaricoside (DIV), a CG isolated from Strophanthus divaricatus was examined for its antitumor potency in oral squ
Externí odkaz:
https://doaj.org/article/b66f054c42de4011a8a80398743508cb
Publikováno v:
Molecules, Vol 27, Iss 4, p 1342 (2022)
Excess synaptic glutamate release has pathological consequences, and the inhibition of glutamate release is crucial for neuroprotection. Kaempferol 3-rhamnoside (KR) is a flavonoid isolated from Schima superba with neuroprotective properties, and its
Externí odkaz:
https://doaj.org/article/e5051904e7e440f39ae067fb61922824
Autor:
Li‐Yuan Bai, Kay Li‐Hui Wu, Chang‐Fang Chiu, Hong‐Chu Chao, Wei‐Yu Lin, Jing‐Lan Hu, Bo‐Rong Peng, Jing‐Ru Weng
Publikováno v:
Environmental Toxicology. 38:666-675
According to the alarming statistical analysis of global cancer, there are over 19 million new diagnoses and more than 10 million deaths each year. One such cancer is the oral squamous cell carcinoma (OSCC), which requires new therapeutic strategies.
Autor:
Jing-Ru Weng, Chun-Hung Hua, Chao-Hsien Chen, Su-Hua Huang, Ching-Ying Wang, Ying-Ju Lin, Lei Wan, Cheng-Wen Lin
Publikováno v:
Journal of Microbiology, Immunology and Infection, Vol 51, Iss 4, Pp 456-464 (2018)
Background: Japanese encephalitis virus (JEV) non-structural protein 5 (NS5) exhibits type I interferon (IFN) antagonists, contributing to immune escape, and even inducing viral anti-apoptosis. This study investigated the anti-apoptotic mechanism of
Externí odkaz:
https://doaj.org/article/5af168b4d1514fff88070dac2187af7c
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 119, Iss , Pp - (2019)
[1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol (CIM) has been used as a bioactive agent for inhibiting tumor growth and angiogenesis via mitogen-activated protein kinase (MAPK) and NF-κB blocking. The present work was undertaken to inv
Externí odkaz:
https://doaj.org/article/5d4e302b16cd44e09d050e649d30b0cd
Publikováno v:
Biomedicines, Vol 9, Iss 11, p 1527 (2021)
Trytanthrin, found in Ban-Lan-Gen, is a natural product containing an indoloquinazoline moiety and has been shown to possess anti-inflammatory and anti-viral activities. Chronic inflammation and hepatitis B are known to be associated with the progres
Externí odkaz:
https://doaj.org/article/736384de732a4fba9f63e7ab6bdfab17
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract In this study, we interrogated the mechanism by which the immunosuppressant FTY720 mediates anticancer effects in oral squamous cell carcinoma (OSCC) cells. FTY720 differentially suppressed the viability of the OSCC cell lines SCC4, SCC25, a
Externí odkaz:
https://doaj.org/article/c320f44d950445378008bb0d47854a3b
Publikováno v:
Chemistry of Natural Compounds. 58:1170-1172
Autor:
Li-Yuan Bai, Jui-Hsin Su, Chang-Fang Chiu, Wei-Yu Lin, Jing-Lan Hu, Chia-Hsien Feng, Chih-Wen Shu, Jing-Ru Weng
Publikováno v:
Marine Drugs, Vol 19, Iss 5, p 244 (2021)
In this study, the anti-proliferative effect of ilimaquinone, a sesquiterpene derivative from the marine sponge, in breast cancer cells was investigated. Ilimaquinone inhibited the proliferation of MCF-7 and MDA-MB-231 breast cancer cells with IC50 v
Externí odkaz:
https://doaj.org/article/b380b536a6e04567a520da6fb5ea7d58