Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Jing Ru Jhan"'
Western blot analysis of ZEB1, E-cadherin and PKCalpha in ARHGAP18 knockout, ARHGAP18 re-expression, miR-200b stable expression and miR-200b-ARHGAP18 double stable expression cells and a schematic summary of the mechanism of miR-200b inhibition of TN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::036f0a8cdb4f7a6c5b2898dc28f61583
https://doi.org/10.1158/0008-5472.22414311.v1
https://doi.org/10.1158/0008-5472.22414311.v1
CRISPR/Cas9 knockout of ARHGAP18 reduces TNBC cell proliferation and migration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c13bd15b99624344fcdc6720726dc4e
https://doi.org/10.1158/0008-5472.22414317
https://doi.org/10.1158/0008-5472.22414317
ARHGAP18 re-expression in miR-200b stably expressing cells reverses the effect of miR-200b on actin cytoskeleton reorganization and RhoA activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af994e90b8c3a8fadd6e009762ace5cb
https://doi.org/10.1158/0008-5472.22414314.v1
https://doi.org/10.1158/0008-5472.22414314.v1
ARHGAP18 expression levels are significantly higher in TNBC tumors than other subtypes of breast cancer and higher ARHGAP18 levels in breast tumors are associated with poorer metastasis free survival.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e0d901ed0e33555cf352fdc8b3533ff
https://doi.org/10.1158/0008-5472.22414320
https://doi.org/10.1158/0008-5472.22414320
A brief summary of three mouse orthotopic mammary xenograft tumor studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61cf6304e1602dca27823f5ba5c276be
https://doi.org/10.1158/0008-5472.22414308.v1
https://doi.org/10.1158/0008-5472.22414308.v1
SiRNA knocking down ARHGAP18 expression alters the actin cytoskeleton reorganization pattern and RhoA and Rac1activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f40872780b67571907f709c28f8f0b0
https://doi.org/10.1158/0008-5472.22414323
https://doi.org/10.1158/0008-5472.22414323
Rho GTPases activated in cancer cells drive proliferation, migration, and metastasis. Thus, RhoGAP proteins, which negatively regulate Rho GTPases, are generally thought to function as tumor suppressors. Here this expectation was challenged by charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9cbba1b28a9358c38e3168434ee888d
https://doi.org/10.1158/0008-5472.c.6508944.v1
https://doi.org/10.1158/0008-5472.c.6508944.v1
Stably expressing miR-200b in TNBC cells reduces focal adhesion turnover
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dfd0dda25129a1197562573df3655a3
https://doi.org/10.1158/0008-5472.22414329.v1
https://doi.org/10.1158/0008-5472.22414329.v1
Inhibition of Rac1 by treating cells with a PKCalpha inhibitor does not affect RhoA activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fff7324c11652c1c0856ab08e623613
https://doi.org/10.1158/0008-5472.22414326.v1
https://doi.org/10.1158/0008-5472.22414326.v1
Autor:
Briana To, Eran R. Andrechek, Rachel E. Rempel, Rachel Kubiak, Jordan Honeysett, Daniel Hollern, Jonathan P. Rennhack, Joseph R. Nevins, Carson D. Broeker, Evan Bylett, Jing Ru Jhan, Lauren Jackson, Shams Reaz, Matt Swiatnicki, David Judah
The development of breast cancer has been observed due to altered regulation of mammary gland developmental processes. Thus, a better understand of the normal mammary gland development can reveal possible mechanism in how normal cells are re-programm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1be897f59ffa0f9c0d494791e194405
https://doi.org/10.1101/2021.09.24.461727
https://doi.org/10.1101/2021.09.24.461727