Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Jing Quan Lan"'
Autor:
David C. Henshall, Shana L. Skradski, Robert Meller, Tomohiro Araki, Manabu Minami, Clara K. Schindler, Jing-Quan Lan, David P. Bonislawski, Roger P. Simon
Publikováno v:
Neurobiology of Disease, Vol 10, Iss 2, Pp 71-87 (2002)
The caspase family of cell death proteases has been implicated in the mechanism of neuronal death following seizures. We investigated the expression and processing of caspases 6 and 7, putative executioner caspases. Brief limbic seizures were evoked
Externí odkaz:
https://doaj.org/article/1c6ba07d93bf4282acc9572331c39fc0
Autor:
David C. Henshall, David P. Bonislawski, Shana L. Skradski, Jing-Quan Lan, Robert Meller, Roger P. Simon
Publikováno v:
Neurobiology of Disease, Vol 8, Iss 4, Pp 568-580 (2001)
The mechanism by which seizures induce neuronal death is not completely understood. Caspase-8 is a key initiator of apoptosis via extrinsic, death receptor-mediated pathways; we therefore investigated its role in mediating seizure-induced neuronal de
Externí odkaz:
https://doaj.org/article/49e7bdb751c14911aa25ac48b8f3bb99
Autor:
Hai-Ying Shen, Paula M Canas, Patricia Garcia-Sanz, Jing-Quan Lan, Detlev Boison, Rosario Moratalla, Rodrigo A Cunha, Jiang-Fan Chen
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80902 (2013)
Adenosine A2A receptors (A2AR) are located postsynaptically in striatopallidal GABAergic neurons, antagonizing dopamine D2 receptor functions, and are also located presynaptically at corticostriatal terminals, facilitating glutamate release. To addre
Externí odkaz:
https://doaj.org/article/7f71e037f8274c1082d7da34a1bce050
Autor:
Rebecca L. Williams-Karnesky, Hai Ying Shen, Jing Quan Lan, Jiang-Fan Chen, Philipp Singer, Detlev Boison, Benjamin K. Yee, Catherine J. Wei, Nikki K. Lytle
Publikováno v:
Journal of Clinical Investigation. 122:2567-2577
An emerging theory of schizophrenia postulates that hypofunction of adenosine signaling may contribute to its pathophysiology. This study was designed to test the "adenosine hypothesis" of schizophrenia and to evaluate focal adenosine-based strategie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0abf9c9fb1d12ff642a7015b9b27116
https://doi.org/10.1172/jci62378
https://doi.org/10.1172/jci62378
Publikováno v:
Glia. 60:83-95
Astrogliosis and associated dysfunction of adenosine homeostasis are pathological hallmarks of the epileptic brain and thought to contribute to seizure generation in epilepsy. The authors hypothesized that astrogliosis-an early component of the epile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab8b4eb46d5550a1a55394da31a7e7d6
https://doi.org/10.1002/glia.21250
https://doi.org/10.1002/glia.21250
Autor:
Theresa A. Lusardi, Carol D. Farr, Giuseppe Pignataro, Craig L Faulkner, Jing-Quan Lan, Julie A. Saugstad, Roger P. Simon, Tao Yang
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 30:744-756
Preconditioning describes the ischemic stimulus that triggers an endogenous, neuroprotective response that protects the brain during a subsequent severe ischemic injury, a phenomenon known as ‘tolerance’. Ischemic tolerance requires new protein s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6fff87ecfeb62ee66a1eae96270d69e
https://doi.org/10.1038/jcbfm.2009.253
https://doi.org/10.1038/jcbfm.2009.253
Autor:
Roger P. Simon, Giuseppe Pignataro, Jing-Quan Lan, Donald F. Steiner, Xiaorong Zhu, An Zhou, Hongbo Zhao, Zhi-Gang Xiong, Aaron J White, Manabu Minami, Tao Yang, Shuqin Zhan
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 29:698-706
Using a focal cerebral ischemia model in rats, brain ischemia-induced changes in expression levels of mRNA and protein, and activities of proprotein convertase 2 (PC2) in the cortex were examined. In situ hybridization analyses revealed a transient u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8786837e0bf2dc8e613d9aa3becedb03
https://doi.org/10.1038/jcbfm.2008.161
https://doi.org/10.1038/jcbfm.2008.161
Publikováno v:
Neuron Glia Biology. 4:91-99
The astrocytic enzyme adenosine kinase (ADK) is a key negative regulator of the brain’s endogenous anticonvulsant adenosine. Astrogliosis with concomitant upregulation of ADK is part of the epileptogenic cascade and contributes to seizure generatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf08a40bd63b4c2bcd97afcd7a2380a
https://doi.org/10.1017/s1740925x09990135
https://doi.org/10.1017/s1740925x09990135
Publikováno v:
Journal of Biological Chemistry. 282:22668-22677
Acid-sensing ion channel (ASIC) 1a and ASIC2a are acid-sensing ion channels in central and peripheral neurons. ASIC1a has been implicated in long-term potentiation of synaptic transmission and ischemic brain injury, whereas ASIC2a is involved in mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a19a108f2770b20ca29731068f883a
https://doi.org/10.1074/jbc.m703624200
https://doi.org/10.1074/jbc.m703624200
Autor:
Dexi Chen, Robert Meller, Manabu Minami, David C. Henshall, Jing Quan Lan, Soren Impey, Roger P. Simon, Jennifer A. Cameron
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 25:234-246
Bcl-2 plays a pivotal role in the control of cell death and is upregulated by ischemic tolerance. Because Bcl-2 expression is regulated by the transcription factor cyclic AMP response element-binding protein (CREB), we investigated the role of CREB a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fe74542c0188417ba5afb011e58f5d5
https://doi.org/10.1038/sj.jcbfm.9600024
https://doi.org/10.1038/sj.jcbfm.9600024