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Akademický článek

Tetraarsenic hexoxide induces G2/M arrest, apoptosis, and autophagy via PI3K/Akt suppression and p38 MAPK activation in SW620 human colon cancer cells.

Autor: Arulkumar Nagappan, Won Sup Lee, Jeong Won Yun, Jing Nan Lu, Seong-Hwan Chang, Jae-Hoon Jeong, Gon Sup Kim, Jin-Myung Jung, Soon Chan Hong

Publikováno v: PLoS ONE, Vol 12, Iss 3, p e0174591 (2017)

Tetraarsenic hexoxide (As4O6) has been used in Korean folk medicines for the treatment of cancer, however its anti-cancer mechanisms remain obscured. Here, this study investigated the anti-cancer effect of As4O6 on SW620 human colon cancer cells. As4

Externí odkaz: https://doaj.org/article/ff99e94e6764438f82c248f1867d1eec

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Anthocyanins From the Fruit of Vitis coignetiae Pulliat Potentiate the Cisplatin Activity by Inhibiting PI3K/Akt Signaling Pathways in Human Gastric Cancer Cells

Autor: Jing Nan Lu, Yung Hyun Choi, Seong-Hwan Chang, Sung Chul Shin, Soon-Chan Hong, Arulkumar Nagappan, Gon Sup Kim, Hye Jung Kim, Jin-Myung Jung, Won Sup Lee, Chung Ho Ryu

Publikováno v: Journal of Cancer Prevention

Background: Cisplatin (cis-diaminedichloroplatinum, CDDP) is a widely used chemotherapeutic agent for the treatment of many cancers. However, initial resistance to CDDP is a serious problem in treating these cancers. Vitis coignetiae Pulliat (Meoru i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5e9985a8063fa32a9d6705906f2265c
http://europepmc.org/articles/PMC4384714

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Synthesized tetrahydroisoquinoline alkaloid exerts anticancer effects at least in part by suppressing NF-κB-regulated proteins in A549 human lung cancer cells

Autor: Min Jeong Kim, Won Sup Lee, Jin-Myung Jung, Dong Hoon Kim, Jeong Won Yun, Jeong-Hee Lee, Arulkumar Nagappan, Ki Churl Chang, Yung Hyun Choi, Jing Nan Lu, Hye Jung Kim

Publikováno v: Oncology Reports. 33:1141-1146

CKD-712, a newly synthesized tetrahydroisoquinoline (THI) and an enantiomer (S form) of YS 49 (a derivative of higenamine) has been reported to suppress nuclear factor-κB (NF-κB) activity in normal cells. In the present study, we investigated the a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ef868ec46560f5522f344511592040
https://doi.org/10.3892/or.2014.3658

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Anthocyanins from the Fruit of Vitis Coignetiae Pulliat Inhibit TNF-Augmented Cancer Proliferation, Migration, and Invasion in A549 Cells

Autor: Jing Nan, Lu, Radha, Panchanathan, Won Sup, Lee, Hye Jung, Kim, Dong Hoon, Kim, Yung Hyun, Choi, Gon Sup, Kim, Sung Chul, Shin, Soon Chan, Hong

Publikováno v: Asian Pacific Journal of Cancer Prevention : APJCP

Objective: Anthocyanins belong to a class of flavonoids, exhibiting antioxidant and anti-inflammatory actions have been reported to have anti-cancer effects. Here, we investigated whether anthocyanins can inhibit cancer cell proliferation, invasion,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6c5075bf8b88956e4d3a7ce0d4de9df9
https://pubmed.ncbi.nlm.nih.gov/29172259

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The inhibitory effect of anthocyanins on Akt on invasion and epithelial-mesenchymal transition is not associated with the anti-EGFR effect of the anthocyanins

Autor: Chung Ho Ryu, Ji Hyun Jung, Hye Jung Kim, Jing Nan Lu, Jeong Won Yun, Yung Hyun Choi, Gon Sup Kim, Sung Chul Shin, Jae Hoon Jeong, Won Sup Lee, Sang Mi Yi, Min Jeong Kim

Publikováno v: International Journal of Oncology. 44:1756-1766

Evidence suggests that anthocyanins inhibit EGFR and Akt activity. However, it is still unknown whether the inhibitory effect of anthocyanins on Akt is associated with the anti-EGFR effect. The effect of anthocyanins on epithelial-mesenchymal transit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bf6ad68df3c275a3aefd536e128902e
https://doi.org/10.3892/ijo.2014.2315

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Tetraarsenic hexoxide induces G2/M arrest, apoptosis, and autophagy via PI3K/Akt suppression and p38 MAPK activation in SW620 human colon cancer cells

Autor: Jeong Won Yun, Jae Hoon Jeong, Jin-Myung Jung, Arulkumar Nagappan, Gon Sup Kim, Soon-Chan Hong, Jing Nan Lu, Won Sup Lee, Seong-Hwan Chang

Publikováno v: PLoS ONE
PLoS ONE, Vol 12, Iss 3, p e0174591 (2017)
PLOS ONE(12): 3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad62d434390123bf387d8ee9d0baafd8
https://pubmed.ncbi.nlm.nih.gov/28355296

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Characterization of a profile of the anthocyanins isolated from Vitis coignetiae Pulliat and their anti-invasive activity on HT-29 human colon cancer cells

Autor: Min Jeong Kim, Dong Chul Kim, Eun-Ju Choi, Yung Hyun Choi, Gon-Sup Kim, Myung Hee Kang, Won Sup Lee, Ock Jin Park, Yun-Kyoung Lee, Sung Chul Shin, Jing Nan Lu, Jeong Won Yun, Hoon Gu Kim, Hae Gyeong Kim, Jin Young Choi, Chung Ho Ryu

Publikováno v: Food and Chemical Toxicology. 48:903-909

We isolated anthocyanins from fruits of Vitis coignetiae Pulliat, characterized the anthocyanin profile, and investigated the anti-invasive effects of the anthocyanins on human colon cancer cells. The anthocyanins inhibited cell invasion in a dose-de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b663704bfef6cf87d0bc3354bbbf2b5
https://doi.org/10.1016/j.fct.2009.12.031

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Tetraarsenic hexoxide demonstrates anticancer activity at least in part through suppression of NF-κB activity in SW620 human colon cancer cells

Autor: Dong Chul Kim, Hye Jung Kim, Arulkumar Nagappan, Jeong Won Yun, Woo Song Ha, Jing Nan Lu, Seong-Hwan Chang, Jeong-Hee Lee, Jin-Myung Jung, Soon-Chan Hong, Won Sup Lee, Gon-Sup Kim, Hyeon Soo Park

Publikováno v: Oncology reports. 33(6)

Tetraarsenic hexoxide (As4O6) has been used in Korean traditional medicine for the treatment of cancer since the late 1980's, and arsenic trioxide (As2O3) is currently used as a chemotherapeutic agent. Previous studies suggest that the As4O6-induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::896a35edce4b92a613c88f3a74facfc5
https://pubmed.ncbi.nlm.nih.gov/25845556

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Abstract 2107: Tetra-arsenic hexoxide induces G2/M cell cycle arrest, apoptosis, and autophagy via p38 MAPK- and AKT-mediated pathways in SW620 human colon cancer cells

Autor: Soon-Chan Hong, Gon-Sup Kim, Jeong Won Yun, Won Sup Lee, Arulkumar Nagappan, Jing Nan Lu, Seong-Hwan Chang, Jae Hoon Jeong, Min Jeong Kim, Jin-Myung Jung

Publikováno v: Cancer Research. 77:2107-2107

Tetraarsenic hexoxide (As4O6) has been used in Korean folk remedy for the treatment of cancer since the late 1980’s. Evidence suggests that As4O6 show anti-cancer effects, whose mechanisms are different from those for As2O3. However, the detailed a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d4f3fca2360d82c51795ceb53917f81
https://doi.org/10.1158/1538-7445.am2017-2107

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Arsenic hexoxide enhances TNF-α-induced anticancer effects by inhibiting NF-κB activity at a safe dose in MCF-7 human breast cancer cells

Autor: Min Jeong Kim, Ji Hyun Jung, Soon-Chan Hong, Hye Jung Kim, Jeong Won Yun, Woo Song Ha, Jing Nan Lu, Sang Mi Yi, Seong-Hwan Chang, Gon-Sup Kim, Won Sup Lee

Publikováno v: Oncology reports. 31(5)

Arsenic hexoxide (As4O6) has been used in Korean folk remedy for the treatment of cancer since the late 1980s. Evidence suggests that the anticancer effects of As4O6 are different from those of As2O3. Tumor necrosis factor-α (TNF-α) is generally in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83356ecba439c5c212d95b53c5ca2b6d
https://pubmed.ncbi.nlm.nih.gov/24627159

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