Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Jing Jin Gu"'
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0241423 (2020)
Mesenchymal stem cells (MSCs) are recruited and activated by solid tumors and play a role in tumor progression and metastasis. Here we show that MSCs promote metastasis in a panel of non-small cell lung cancer (NSCLC) cells. MSCs elicit transcription
Externí odkaz:
https://doaj.org/article/247d3ac705c74d2d934ffe5523d82253
Autor:
Jacob P. Hoj, Clay Rouse, Nancie J. MacIver, Amanda G. Nichols, Jillian Hattaway Luttman, Kevin H. Lin, Kris C. Wood, Ann Marie Pendergast, Jiaxing Lin, Jing Jin Gu
Publikováno v:
Cell reports
SUMMARY Targeting mitochondrial metabolism has emerged as a treatment option for cancer patients. The ABL tyrosine kinases promote metastasis, and enhanced ABL signaling is associated with a poor prognosis in lung adenocarcinoma patients. Here we sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac3a7fec1865bf9febb49ff2a22c195c
Publikováno v:
Oncotarget
Scopus-Elsevier
Scopus-Elsevier
// Aaditya Khatri 1 , Jing Jin Gu 1 , Courtney M. McKernan 1 , Xia Xu 1 and Ann Marie Pendergast 1 1 Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA Correspondence to: Ann Marie Pendergast, email: ann.pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::894bd1dd2a8dce6eb361b75835102bef
https://doi.org/10.18632/oncotarget.26740
https://doi.org/10.18632/oncotarget.26740
Current therapies to treat non-small cell lung carcinoma (NSCLC) have proven ineffective owing to transient, variable, and incomplete responses. Here we show that ABL kinases, ABL1 and ABL2, promote metastasis of lung cancer cells harboring EGFR or K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b115b010e2c1929880189a37668f551
https://europepmc.org/articles/PMC5161211/
https://europepmc.org/articles/PMC5161211/
Publikováno v:
Immunological Reviews. Mar2009, Vol. 228 Issue 1, p170-183. 14p. 4 Diagrams.
Publikováno v:
The Journal of Immunology. 179:7334-7343
Thymocyte proliferation, survival, and differentiation are tightly controlled by signaling from the pre-TCR. In this study, we show for the first time that the Abelson (Abl) kinases regulate proximal signaling downstream of the pre-TCR. Conditional d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f32dd44eece260a60edc402f80d04738
https://doi.org/10.4049/jimmunol.179.11.7334
https://doi.org/10.4049/jimmunol.179.11.7334
Publikováno v:
Journal of Biological Chemistry. 277:28364-28367
While investigating the ability of p38 MAPK to regulate cytarabine (Ara C)-dependent differentiation of erythroleukemia K562 cells, we observed effects that indicated that the imidazoline class of p38 MAPK inhibitors prevented nucleoside transport. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6077e6fee4fc4c8cdc2b65b3196286a2
https://doi.org/10.1074/jbc.c200321200
https://doi.org/10.1074/jbc.c200321200
Publikováno v:
Journal of Biological Chemistry. 272:4458-4466
Catalysis of guanine nucleotide formation from IMP in the de novo purine synthetic pathway is carried out by two isoforms of the enzyme inosine monophosphate dehydrogenase (IMPDH) that are catalytically indistinguishable but are encoded by separate g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14309d1944121c9f7c321d5d820eb2f4
https://doi.org/10.1074/jbc.272.7.4458
https://doi.org/10.1074/jbc.272.7.4458
Publikováno v:
Advances in Enzyme Regulation. 36:75-84
Inosine 5′-monophosphate dehydrogenase (IMPDH) is an essential ratelimiting enzyme in the de novo guanine nucleotide synthetic pathway that catalyzes the conversion of IMP to XMP. Enzyme activity is accounted for by the expression of two distinct b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2ba4a3f7e06542fe10fed9dc48e227c
https://doi.org/10.1016/0065-2571(95)00012-7
https://doi.org/10.1016/0065-2571(95)00012-7
Autor:
Erik J. Soderblom, Elena N. Pugacheva, Ann Marie Pendergast, M. Arthur Moseley, Catherine Lavau, Jing Jin Gu
Chemokine signaling is critical for T cell function during homeostasis and inflammation and directs T cell polarity and migration through the activation of specific intracellular pathways. Here, we uncovered a previously uncharacterized role for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b915d4b73183b00582cc6230c7f14f
https://europepmc.org/articles/PMC3602906/
https://europepmc.org/articles/PMC3602906/