Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Jing Han Hong"'
Autor:
Patrick S. Plum, Timo Hess, Denis Bertrand, Isabelle Morgenstern, Oscar Velazquez Camacho, Christoph Jonas, Christina Alidousty, Britta Wagner, Stephanie Roessler, Thomas Albrecht, Jessica Becker, Vanessa Richartz, Barbara Holz, Sascha Hoppe, Huay Mei Poh, Burton Kuan Hui Chia, Cheryl Xueli Chan, Thushangi Pathiraja, Audrey SM Teo, Jens U. Marquardt, Alexis Khng, Michael Heise, Yao Fei, René Thieme, Sebastian Klein, Jing Han Hong, Simona O Dima, Irinel Popescu, Maria Hoppe‐Lotichius, Reinhard Buettner, Anja Lautem, Gerd Otto, Alexander Quaas, Niranjan Nagarajan, Steve Rozen, Bin Tean Teh, Benjamin Goeppert, Uta Drebber, Hauke Lang, Patrick Tan, Ines Gockel, Johannes Schumacher, Axel M. Hillmer
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 6, Pp n/a-n/a (2024)
Abstract Background Cholangiocarcinoma (CCA) is a fatal cancer of the bile duct with a poor prognosis owing to limited therapeutic options. The incidence of intrahepatic CCA (iCCA) is increasing worldwide, and its molecular basis is emerging. Environ
Externí odkaz:
https://doaj.org/article/26260a111e4f40929c73d9cf914a4148
Autor:
Lizhen Liu, Peng Deng, Sailan Liu, Jing Han Hong, Rong Xiao, Peiyong Guan, Yali Wang, Peili Wang, Jiuping Gao, Jinghong Chen, Yichen Sun, Jianfeng Chen, Hai-Qiang Mai, Jing Tan
Publikováno v:
Cell Death and Disease, Vol 14, Iss 8, Pp 1-12 (2023)
Abstract Acquired resistance to chemotherapy is one of the major causes of mortality in advanced nasopharyngeal carcinoma (NPC). However, effective strategies are limited and the underlying molecular mechanisms remain elusive. In this study, through
Externí odkaz:
https://doaj.org/article/1bdffcc862c14d5fbf6c15dd5b641646
Autor:
Jianfeng Chen, Jing Han Hong, Yulin Huang, Shini Liu, Jiaxin Yin, Peng Deng, Yichen Sun, Zhaoliang Yu, Xian Zeng, Rong Xiao, Jason Yongsheng Chan, Peiyong Guan, Yali Wang, Peili Wang, Lizhen Liu, Shijun Wen, Qiang Yu, Choon Kiat Ong, Bin-Tean Teh, Ying Xiong, Jing Tan
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-15 (2023)
Abstract Background Enhancer of zeste homolog 2 (EZH2), the key catalytic subunit of polycomb repressive complex 2 (PRC2), is overexpressed and plays an oncogenic role in various cancers through catalysis-dependent or catalysis-independent pathways.
Externí odkaz:
https://doaj.org/article/b67020e61b6748208cb6b5f34e466c59
Autor:
Jinghong Chen, Zhixiang Zuo, Yan Gao, Xiaosai Yao, Peiyong Guan, Yali Wang, Zhimei Li, Zhilong Liu, Jing Han Hong, Peng Deng, Jason Yongsheng Chan, Daryl Ming Zhe Cheah, Jingquan Lim, Kelila Xin Ye Chai, Burton Kuan Hui Chia, Jane Wan Lu Pang, Joanna Koh, Dachuan Huang, Haixia He, Yichen Sun, Lizhen Liu, Shini Liu, Yuhua Huang, Xiaoxiao Wang, Hua You, Sahil Ajit Saraf, Nicholas Francis Grigoropoulos, Xiaoqiu Li, Jinxin Bei, Tiebang Kang, Soon Thye Lim, Bin Tean Teh, Huiqiang Huang, Choon Kiat Ong, Jing Tan
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-16 (2023)
Abstract Background Natural killer/T-cell lymphoma (NKTL) is a rare type of aggressive and heterogeneous non-Hodgkin's lymphoma (NHL) with a poor prognosis and limited therapeutic options. Therefore, there is an urgent need to exploit potential novel
Externí odkaz:
https://doaj.org/article/63014556270748ed98fa1bb18898c8a1
Autor:
Divya Khosla, Shagun Misra, Pek Lim Chu, Peiyong Guan, Ritambhra Nada, Rajesh Gupta, Khwanta Kaewnarin, Tun Kiat Ko, Hong Lee Heng, Vijay Kumar Srinivasalu, Rakesh Kapoor, Deepika Singh, Poramate Klanrit, Somponnat Sampattavanich, Jing Tan, Sarinya Kongpetch, Apinya Jusakul, Bin Tean Teh, Jason Yongsheng Chan, Jing Han Hong
Publikováno v:
Cancers, Vol 16, Iss 4, p 801 (2024)
Cholangiocarcinomas (CCA) pose a complex challenge in oncology due to diverse etiologies, necessitating tailored therapeutic approaches. This review discusses the risk factors, molecular pathology, and current therapeutic options for CCA and explores
Externí odkaz:
https://doaj.org/article/fba92e29db7c4b5fb94759ca636ebf0d
Autor:
Yali Wang, Wenbo Zhou, Jianfeng Chen, Jinghong Chen, Peng Deng, Huang Chen, Yichen Sun, Zhaoliang Yu, Diwen Pang, Lizhen Liu, Peili Wang, Jing Han Hong, Bin Tean Teh, Huiqiang Huang, Wenyu Li, Zhengfang Yi, Soon Thye Lim, Yihua Chen, Choon Kiat Ong, Mingyao Liu, Jing Tan
Publikováno v:
MedComm, Vol 4, Iss 4, Pp n/a-n/a (2023)
Abstract Natural killer/T‐cell lymphoma (NKTL) is an uncommon malignancy with poor prognosis and limited therapeutic options. Activating mutations of signal transducer and activator of transcription 3 (STAT3) are frequently found in patients with N
Externí odkaz:
https://doaj.org/article/e18efbf266124b799349530a6ced4565
Autor:
Abner Herbert Lim, Zhen Jie Low, Prashant Narendra Shingate, Jing Han Hong, Shu Chen Chong, Cedric Chuan Young Ng, Wei Liu, Robert Vaser, Mile Šikić, Wing-Kin Ken Sung, Niranjan Nagarajan, Patrick Tan, Bin Tean Teh
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Genome assembly and metabolomic analysis of Singapore’s national flower, Papilionanthe (Ple.) Miss Joaquim “Agnes” (PMJ), expands the known genetic repertoire of the Orchidaceae family and insights into the biochemical processes of PMJ.
Externí odkaz:
https://doaj.org/article/57deaff736324f6cbaf969e69093bdfb
Autor:
Dave Yong Xiang Ng, Zhimei Li, Elizabeth Lee, Jessica Sook Ting Kok, Jing Yi Lee, Joanna Koh, Cedric Chuan-Young Ng, Abner Herbert Lim, Wei Liu, Sheng Rong Ng, Kah Suan Lim, Xi Xiao Huang, Jing Han Hong, Peiyong Guan, Yirong Sim, Aye Aye Thike, Nur Diyana Md Nasir, Shang Li, Puay Hoon Tan, Bin Tean Teh, Jason Yongsheng Chan
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-10 (2022)
Abstract Malignant phyllodes tumors (PT) are rare aggressive fibroepithelial neoplasms with high metastatic potential and lack effective therapy. We established a patient-derived xenograft (PDX) and cell line model (designated MPT-S1) of malignant PT
Externí odkaz:
https://doaj.org/article/bd28bd0bf05246bbaccb1e4e99e36462
Autor:
Peng Deng, Zining Wang, Jinghong Chen, Shini Liu, Xiaosai Yao, Shaoyan Liu, Lizhen Liu, Zhaoliang Yu, Yulin Huang, Zhongtang Xiong, Rong Xiao, Jiuping Gao, Weiting Liang, Jieping Chen, Hui Liu, Jing Han Hong, Jason Yongsheng Chan, Peiyong Guan, Jianfeng Chen, Yali Wang, Jiaxin Yin, Jundong Li, Min Zheng, Chao Zhang, Penghui Zhou, Tiebang Kang, Bin Tean Teh, Qiang Yu, Zhixiang Zuo, Qingping Jiang, Jihong Liu, Ying Xiong, Xiaojun Xia, Jing Tan
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 22 (2022)
Prevalent copy number alteration is the most prominent genetic characteristic associated with ovarian cancer (OV) development, but its role in immune evasion has not been fully elucidated. In this study, we identified RAD21, a key component of the co
Externí odkaz:
https://doaj.org/article/d1d685a0f6e94ed4ad24a9147d62ada6
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Histone deacetylase (HDAC) is one of the most characterized epigenetic modifiers, modulating chromatin structure and gene expression, which plays an important role in cell cycle, differentiation and apoptosis. Dysregulation of HDAC promotes cancer pr
Externí odkaz:
https://doaj.org/article/5ee0e6a960434778bae5a5f64b22eb4b