Zobrazeno 1 - 10
of 9 284
pro vyhledávání: '"Jing H."'
Autor:
Arpitha H. Shivarudrappa, Jessy John, Monika Vashisht, Huaibin Ge, Silvia Liu, Jingxin Chen, Karen Siddoway, Rui Dong, Zhangguo Chen, Jing H. Wang
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Human papilloma virus (HPV) is an etiological factor of head and neck squamous cell carcinoma (HNSCC). To investigate the role of HPV antigen in anti-tumor immunity, we established mouse models by expressing HPV16 E6 and E7 in a SCC tumor cell line.
Externí odkaz:
https://doaj.org/article/a4f25552ea5c458f829ea2dd07b38b2a
Autor:
Monika Vashisht, Huaibin Ge, Jessy John, Harlie A. McKelvey, Jingxin Chen, Zhangguo Chen, Jing H. Wang
Publikováno v:
Cell Death and Disease, Vol 14, Iss 9, Pp 1-15 (2023)
Abstract Deletion of TRAF2 or TRAF3 in B cells prolongs their survival. However, it remains unknown whether deletion of such factors affects B cells’ ability to tolerate DNA damage, which can be induced by chemotherapeutics and cause apoptosis. Gen
Externí odkaz:
https://doaj.org/article/3f89235a4a394b3495c5a44df88a97b4
Autor:
Mohamed K. Abdelhakiem, Riyue Bao, Phillip M. Pifer, David Molkentine, Jessica Molkentine, Andrew Hefner, Beth Beadle, John V. Heymach, Jason J. Luke, Robert L. Ferris, Curtis R. Pickering, Jing H. Wang, Ravi B. Patel, Heath D. Skinner
Publikováno v:
Cancers, Vol 16, Iss 8, p 1586 (2024)
The curative treatment of multiple solid tumors, including head and neck squamous cell carcinoma (HNSCC), utilizes radiation. The outcomes for HPV/p16-negative HNSCC are significantly worse than HPV/p16-positive tumors, with increased radiation resis
Externí odkaz:
https://doaj.org/article/4db4007c8f0f4ef7bda7222f9e858d99
Autor:
Jessy John, Samantha M. Y. Chen, Rachel A. Woolaver, Huaibin Ge, Monika Vashisht, Ziyu Huang, Zhangguo Chen, Jing H. Wang
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment; however, the responses to ICI treatment are highly variable in different individuals and the underlying mechanisms remain poorly understood. Here, we employed a mouse squamous
Externí odkaz:
https://doaj.org/article/d37efbe2fd27490894a7e6687b1d22c5
Autor:
Samantha M. Y. Chen, Vince Popolizio, Rachel A. Woolaver, Huaibin Ge, Alexandra L. Krinsky, Jessy John, Etienne Danis, Yao Ke, Yonatan Kramer, Li Bian, Andrew G. Nicklawsky, Dexiang Gao, Silvia Liu, Zhangguo Chen, Xiao-jing Wang, Jing H. Wang
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-24 (2022)
Abstract Background While immune checkpoint inhibitors (ICI) were approved for head and neck squamous cell carcinomas (HNSCCs), the response rate remains relatively low. Mechanisms underlying ICI unresponsiveness versus sensitivity are not fully unde
Externí odkaz:
https://doaj.org/article/fe3ccf84926d43a5bceb19b100126efd
Autor:
Alexander A. Strait, Rachel A. Woolaver, Spencer C. Hall, Christian D. Young, Sana D. Karam, Antonio Jimeno, Yan Lan, David Raben, Jing H. Wang, Xiao-Jing Wang
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Strait et al describe distinct immune microenvironment profiles of responders versus non-responders to combined TGF-β/PD-L1 blockade in mouse models of squamous cell carcinoma (SCC). The results emphasize the potential of combined TGF-β/PD-L1 targe
Externí odkaz:
https://doaj.org/article/5bc8510595ab4074a4ee88ee8f72c43b
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment including in head and neck squamous cell carcinomas (HNSCCs); however, only a fraction of HNSCC patients respond to ICI, whereas the majority fail to do so. The mechanisms under
Externí odkaz:
https://doaj.org/article/9b3c6720bbda4c62a131f39cf37bc4a5
Autor:
Jessy John, Rachel A. Woolaver, Vince Popolizio, Samantha M. Y. Chen, Huaibin Ge, Alexandra L. Krinsky, Monika Vashisht, Yonatan Kramer, Zhangguo Chen, Jing H. Wang
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Differential responses to immune checkpoint inhibitors (ICI) may be attributed to tumor-intrinsic factors or environmental cues; however, these mechanisms cannot fully explain the variable ICI responses in different individuals. Here, we investigate
Externí odkaz:
https://doaj.org/article/f5b78caa49bf4ebaae7aefd9334011c3
A noteworthy discovery is that the minimal evolution time is smaller for parity-time ($\mathcal{PT}$) symmetric systems compared to Hermitian setups. Moreover, there is a significant acceleration of two-qubit quantum entanglement preparation near the
Externí odkaz:
http://arxiv.org/abs/2407.08525
Autor:
Xiaoguang Wang, Brittany C. Waschke, Rachel A Woolaver, Samantha M. Y. Chen, Zhangguo Chen, Jing H. Wang
Publikováno v:
Protein & Cell, Vol 11, Iss 7, Pp 472-482 (2020)
Abstract Immunotherapy has been applied successfully to treat B-cell lymphomas in preclinical models or clinical settings. However, immunotherapy resistance is a major challenge for B-cell lymphoma treatment. To overcome this issue, combinatorial the
Externí odkaz:
https://doaj.org/article/d9e84d707dd3487cac150e395a2a17fd