Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Jing（方靖） Fang"'
Autor:
Yi-Ming Xu, Ying Chen, Guo-Hua Fong, Tang-Long Yuan, Hai-Sheng Zhang, Guohao Wu, Heng Sun, Jing（方靖） Fang, Chen-Guang Bai, Qiulei Xi, Yan-Qing Qin, li（范莉） Fan, Zhi-Qiang Ling
Publikováno v:
Journal of Biological Chemistry. 290:20580-20589
Prolyl hydroxylase domain proteins (PHDs) control cellular adaptation to hypoxia. PHDs are found involved in inflammatory bowel disease (IBD); however, the exact role of PHD3, a member of the PHD family, in IBD remains unknown. We show here that PHD3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc8f8014fa44320592a207460ab191f
https://doi.org/10.1074/jbc.m115.653584
https://doi.org/10.1074/jbc.m115.653584
Autor:
Jun Han, Qiulei Xi, Qingyang Meng, Yi Jiang, Bo Zhang, Guohao Wu, Yusong Han, Jing（方靖） Fang, Qiulin Zhuang, Lei Yuan
Publikováno v:
Oncology Reports. 33:2261-2268
Muscle atrophy F-Box (MAFbx)/atrogin-1 and muscle ring-finger-1 (MuRF-1) have been identified as two muscle-specific E3 ubiquitin ligases that are highly expressed in skeletal muscle during muscle atrophy. However, the role of muscle-specific E3 ubiq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8aef7b6150866a4cf81b170aa98a142
https://doi.org/10.3892/or.2015.3845
https://doi.org/10.3892/or.2015.3845
Autor:
Hai-Sheng Zhang, Yun-Fang Zhang, Xuebing Li, Bing Yan, li（范莉） Fan, Jing（方靖） Fang, Guohao Wu, Min Li
Publikováno v:
Journal of Biological Chemistry. 287:44164-44172
Paired box (PAX) 2, a transcription factor, plays a critical role in embryogenesis. When aberrantly expressed in adult tissues, it generally exhibits oncogenic properties. However, the underlying mechanisms remain unclear. We reported previously that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::938b3cbd383db93225cfb1f42be125f2
https://doi.org/10.1074/jbc.m112.401521
https://doi.org/10.1074/jbc.m112.401521
Autor:
Xue-bing Li, Yi Jiang, Bo Zhang, Cheng-Fu Zhou, Guohao Wu, Heng Sun, Yusong Han, Jing（方靖） Fang, Qiulin Zhuang
Publikováno v:
IUBMB Life. 64:775-782
Pyruvate kinase type M2 (PKM2) has been reported to be involved in aerobic glycolysis and cell growth in various tumors. However, the expression pattern of PKM2 in colorectal cancer (CRC) and the correlation between PKM2 expression and CRC remains un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00bef0ee7cdf0a7ddeee21700100f613
https://doi.org/10.1002/iub.1066
https://doi.org/10.1002/iub.1066
Publikováno v:
Journal of Biological Chemistry. 287:17737-17745
FOXO3a, a member of the Forkhead box O (FoxO) transcription factor family, is believed to be a tumor suppressor because it was found that FOXO3a inactivation promoted cell transformation and tumor progression. There are also a few studies showing tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8447048a327196dd75b189638d0d0b13
https://doi.org/10.1074/jbc.m111.291708
https://doi.org/10.1074/jbc.m111.291708
Publikováno v:
Molecular and Cellular Biochemistry. 358:257-263
The prolyl hydroxylase domain enzymes (PHDs) play the most notable role in cellular oxygen sensing and oxygen homeostasis, the transcription of PHD genes are involved in the protection against hypoxia and oxidative stress. Intratumoral hypoxia exists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0671ec7a3842b9bcc62a5c7b6e24fa7
https://doi.org/10.1007/s11010-011-0976-1
https://doi.org/10.1007/s11010-011-0976-1
Autor:
Jing Xue, Guohao Wu, Dandan Lv, Jing（方靖） Fang, Shi Jiao, Bing Yan, li（范莉） Fan, Hai-Sheng Zhang
Publikováno v:
Biochemical and Biophysical Research Communications. 409:315-320
Prolyl hydroxylase domain proteins (PHDs) hydroxylate HIFα in the presence of oxygen, leading to HIFα proteasomal destruction. The PHDs family comprises PHD1, 2, and 3. Recent studies indicate that, in addition to HIFα, PHDs have other substrates.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::283a1435dbe21e200f6e12778b157ce7
https://doi.org/10.1016/j.bbrc.2011.05.012
https://doi.org/10.1016/j.bbrc.2011.05.012
Publikováno v:
Gastroenterology. 138:606-615
Background & Aims Prolyl hydroxylase (PHD) hydroxylates hypoxia inducible factor (HIF) α, leading to HIFα degradation. The PHD family comprises PHD1, PHD2, and PHD3. The enzymatic activity of PHDs is O 2 -dependent, so PHDs are believed to be oxyge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bacf74306e6cc7f70f08873194d276bc
https://doi.org/10.1053/j.gastro.2009.09.049
https://doi.org/10.1053/j.gastro.2009.09.049
Publikováno v:
Cardiovascular Research. 80:299-308
Aims We showed previously that insulin-like growth factor-I (IGF-I)-induced vascular smooth muscle cells (VSMCs) proliferation through the production of reactive oxygen species (ROS). However, how IGF-I-induced ROS was unknown. The aim of this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9df1efdb34350867cb3db38ecd53c06
https://doi.org/10.1093/cvr/cvn173
https://doi.org/10.1093/cvr/cvn173
Publikováno v:
Molecular Cancer Therapeutics. 6:2581-2590
The mammalian lignan enterolactone is a major metabolite of plant-based lignans that has been shown to inhibit the growth and development of prostate cancer. However, little is known about the mechanistic basis for its anticancer activity. In this st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a9ecc8c9d4cdf6ad5029b1bc8fb31d
https://doi.org/10.1158/1535-7163.mct-07-0220
https://doi.org/10.1158/1535-7163.mct-07-0220