Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Jing‐Yi Jeng"'
Autor:
Carlos Aguilar, Debbie Williams, Ramakrishna Kurapati, Rasneer S. Bains, Philomena Mburu, Andy Parker, Jackie Williams, Danilo Concas, Hilda Tateossian, Andrew R. Haynes, Gareth Banks, Pratik Vikhe, Ines Heise, Marie Hutchison, Gemma Atkins, Simon Gillard, Becky Starbuck, Simona Oliveri, Andrew Blake, Siddharth Sethi, Saumya Kumar, Tanaya Bardhan, Jing-Yi Jeng, Stuart L. Johnson, Lara F. Corns, Walter Marcotti, Michelle Simon, Sara Wells, Paul K. Potter, Heena V. Lad
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110170- (2024)
Summary: Despite some evidence indicating diverse roles of whirlin in neurons, the functional corollary of whirlin gene function and behavior has not been investigated or broadly characterized. A single nucleotide variant was identified from our rece
Externí odkaz:
https://doaj.org/article/8421d27753b841d7bc0fb0382fdbd3c7
Autor:
Adam J. Carlton, Jing-Yi Jeng, Fiorella C. Grandi, Francesca De Faveri, Ana E. Amariutei, Lara De Tomasi, Andrew O’Connor, Stuart L. Johnson, David N. Furness, Steve D.M. Brown, Federico Ceriani, Michael R. Bowl, Mirna Mustapha, Walter Marcotti
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114025- (2024)
Summary: Type I spiral ganglion neurons (SGNs) convey sound information to the central auditory pathway by forming synapses with inner hair cells (IHCs) in the mammalian cochlea. The molecular mechanisms regulating the formation of the post-synaptic
Externí odkaz:
https://doaj.org/article/003f391f46fe499b876a09eda87c4a9d
Autor:
Jing-Yi Jeng, Adam J. Carlton, Richard J. Goodyear, Colbie Chinowsky, Federico Ceriani, Stuart L. Johnson, Tsung-Chang Sung, Yelena Dayn, Guy P. Richardson, Michael R. Bowl, Steve D.M. Brown, Uri Manor, Walter Marcotti
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 355-370 (2022)
The transduction of acoustic information by hair cells depends upon mechanosensitive stereociliary bundles that project from their apical surface. Mutations or absence of the stereociliary protein EPS8 cause deafness in humans and mice, respectively.
Externí odkaz:
https://doaj.org/article/5942f8bc16104f7a85b0dffab23f1f8b
Publikováno v:
Royal Society Open Science, Vol 10, Iss 6 (2023)
Hearing loss is the most common sensory deficit experienced by humans and represents one of the largest chronic health conditions worldwide. It is expected that around 10% of the world's population will be affected by disabling hearing impairment by
Externí odkaz:
https://doaj.org/article/3d8b373fd34b4f61a61ddbf341419d2f
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
The ability of cochlear hair cells to convert sound into receptor potentials relies on the mechanoelectrical transducer (MET) channels present in their stereociliary bundles. There is strong evidence implying that transmembrane channel-like protein (
Externí odkaz:
https://doaj.org/article/bb4207df85eb4920991cb25b32850069
Autor:
Adam J Carlton, Jing‐Yi Jeng, Fiorella C Grandi, Francesca De Faveri, Federico Ceriani, Lara De Tomasi, Anna Underhill, Stuart L Johnson, Kevin P Legan, Corné J Kros, Guy P Richardson, Mirna Mustapha, Walter Marcotti
Publikováno v:
The EMBO Journal. 42
Autor:
Adam J, Carlton, Jing-Yi, Jeng, Fiorella C, Grandi, Francesca, De Faveri, Federico, Ceriani, Lara, De Tomasi, Anna, Underhill, Stuart L, Johnson, Kevin P, Legan, Corné J, Kros, Guy P, Richardson, Mirna, Mustapha, Walter, Marcotti
Publikováno v:
The EMBO journalReferences.
Sensory-independent Ca
Autor:
Lukas Rüttiger, Stuart L. Johnson, Adam J Carlton, Kevin P. Legan, Jing-Yi Jeng, Philine Marchetta, Guy P. Richardson, Richard J. Goodyear, Laura F. Corns, Csaba Harasztosi, Walter Marcotti
Publikováno v:
The Journal of Physiology. 599:2015-2036
Key points The aim was to determine whether detachment of the tectorial membrane (TM) from the organ of Corti in Tecta/Tectb-/- mice affects the biophysical properties of cochlear outer hair cells (OHCs). Tecta/Tectb-/- mice have highly elevated hear
Autor:
Adam J Carlton, Michael R. Bowl, Julia Halford, Steve D.M. Brown, Jing-Yi Jeng, Walter Marcotti, Matthew R. Avenarius, Merle L. Gilbert, Kimimuepigha Ebisine, Peter G. Barr-Gillespie, Federico Ceriani, Anna Underhill
Publikováno v:
The Journal of Physiology
Key points Mechanoelectrical transduction at auditory hair cells requires highly specialized stereociliary bundles that project from their apical surface, forming a characteristic graded ‘staircase’ structure.The morphogenesis and maintenance of