Zobrazeno 1 - 10
of 191
pro vyhledávání: '"Jing‐Dong J Han"'
Autor:
Jia Li, Lei Sun, Xue-Liang Peng, Xiao-Ming Yu, Shao-Jun Qi, Zhi John Lu, Jing-Dong J Han, Qin Shen
Publikováno v:
PLoS Genetics, Vol 17, Iss 3, p e1009355 (2021)
Neurogenesis in the developing neocortex begins with the generation of the preplate, which consists of early-born neurons including Cajal-Retzius (CR) cells and subplate neurons. Here, utilizing the Ebf2-EGFP transgenic mouse in which EGFP initially
Externí odkaz:
https://doaj.org/article/7dade1f4882f415ca528be26cb60307e
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 9, p e1006416 (2018)
Combinatorial effects of epigenetic modifications on transcription activity have been proposed as "histone codes". However, it is unclear whether there also exist inter-nucleosomal communications among epigenetic modifications at single nucleosome le
Externí odkaz:
https://doaj.org/article/5c1bb8bd80ef42ba997d6fa7e3667261
Autor:
Xueqing Wang, Quanlong Jiang, Hongdao Zhang, Zhidong He, Yuanyuan Song, Yifan Chen, Na Tang, Yifei Zhou, Yiping Li, Adam Antebi, Ligang Wu, Jing-Dong J. Han, Yidong Shen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Ageing exhibits common and distinct features in various tissues, making it critical to decipher the tissue-specific ageing mechanisms. MiRNAs are essential regulators in ageing and are recently highlighted as a class of intercellular messeng
Externí odkaz:
https://doaj.org/article/da17e9f86f534a52a3fe2de9d948ee2e
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74074 (2013)
A routine approach to inferring functions for a gene set is by using function enrichment analysis based on GO, KEGG or other curated terms and pathways. However, such analysis requires the existence of overlapping genes between the query gene set and
Externí odkaz:
https://doaj.org/article/a7a16ef67cf243cca6075ef4709ef814
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 3, p e1002998 (2013)
Identifying drug-drug interactions (DDIs) is a major challenge in drug development. Previous attempts have established formal approaches for pharmacokinetic (PK) DDIs, but there is not a feasible solution for pharmacodynamic (PD) DDIs because the end
Externí odkaz:
https://doaj.org/article/468eec5f121e4121a60e8a6b1411bdf9
Publikováno v:
PLoS Genetics, Vol 9, Iss 9, p e1003757 (2013)
Genome-wide gene expression profiles accumulate at an alarming rate, how to integrate these expression profiles generated by different laboratories to reverse engineer the cellular regulatory network has been a major challenge. To automatically infer
Externí odkaz:
https://doaj.org/article/7d6426b64b884cf5b51e9c3054781025
Autor:
Fang Chen, Wei Zhang, Yu Liang, Jialiang Huang, Kui Li, Christopher D Green, Jiancheng Liu, Guojie Zhang, Bing Zhou, Xin Yi, Wei Wang, Hang Liu, Xiaohong Xu, Feng Shen, Ning Qu, Yading Wang, Guoyi Gao, A San, LuoSang JiangBai, Hua Sang, Xiangdong Fang, Karsten Kristiansen, Huanming Yang, Jun Wang, Jing-Dong J Han, Jian Wang
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31645 (2012)
Extreme altitude can induce a range of cellular and systemic responses. Although it is known that hypoxia underlies the major changes and that the physiological responses include hemodynamic changes and erythropoiesis, the molecular mechanisms and si
Externí odkaz:
https://doaj.org/article/07ad80ec5b1947c798b004775b2fe8e2
Autor:
Nicolas Bertin, Nicolas Simonis, Denis Dupuy, Michael E Cusick, Jing-Dong J Han, Hunter B Fraser, Frederick P Roth, Marc Vidal
Publikováno v:
PLoS Biology, Vol 5, Iss 6, p e153 (2007)
Externí odkaz:
https://doaj.org/article/b7b36cd004444afba43298e52e84e0aa
Autor:
Kai Xia, Huiling Xue, Dong Dong, Shanshan Zhu, Jiamu Wang, Qingpeng Zhang, Lei Hou, Hua Chen, Ran Tao, Zheng Huang, Zheng Fu, Ye-Guang Chen, Jing-Dong J Han
Publikováno v:
PLoS Computational Biology, Vol 2, Iss 11, p e145 (2006)
The protein-protein interaction networks, or interactome networks, have been shown to have dynamic modular structures, yet the functional connections between and among the modules are less well understood. Here, using a new pipeline to integrate the
Externí odkaz:
https://doaj.org/article/7b3dc5a02e28451e96c64fbb1e3db46c
Autor:
Xiaoli Zhang, Quanlong Jiang, Jiyang Li, Shiqiang Zhang, Yaqiang Cao, Xian Xia, Donghong Cai, Jiaqi Tan, Jiekai Chen, Jing-Dong J. Han
Publikováno v:
Nature Cell Biology. 24:1617-1629
Transposon (de)repression and heterochromatin reorganization are dynamically regulated during cell fate determination and are hallmarks of cellular senescence. However, whether they are sequence specifically regulated remains unknown. Here we uncover
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb15a6858f389b08dc875987f0ea8766
https://doi.org/10.1038/s41556-022-01008-5
https://doi.org/10.1038/s41556-022-01008-5