Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Jiney Jose"'
Autor:
Elizabeth Cooper, Caitlin R. M. Oyagawa, Rebecca Johnson, Peter J. Choi, Jena Macapagal Foliaki, Jason Correia, Patrick Schweder, Peter Heppner, Edward Mee, Clinton Turner, Richard Faull, William A. Denny, Mike Dragunow, Jiney Jose, Thomas I-H. Park
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Glioblastoma is the most common and aggressive primary brain tumour in adults. The development of anti-brain cancer agents are challenged by the blood-brain barrier and the resistance conferred by the local tumour microenvironment. Heptameth
Externí odkaz:
https://doaj.org/article/e89e926fe6974ecaa78c8ebfb63ce277
Publikováno v:
Results in Chemistry, Vol 4, Iss , Pp 100343- (2022)
The use of heptamethine cyanine dyes (HMCD) as a vehicle for targeted delivery of drugs to cancer tissues shows promise. The synthesis of drug–dye conjugates is hampered by scalability and purification issues. Herein we disclose synthetic procedure
Externí odkaz:
https://doaj.org/article/6867163edde540debaccaa9bf1556810
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 59 (2022)
Glioblastoma multiforme (GBM) is an aggressive brain tumor with high mortality rates. Due to its invasiveness, heterogeneity, and incomplete resection, the treatment is very challenging. Targeted therapies such as tyrosine kinase inhibitors (TKIs) ha
Externí odkaz:
https://doaj.org/article/19777ceabcf34d37bb1086017c2a5c73
Autor:
Elizabeth Cooper, Peter J. Choi, William A. Denny, Jiney Jose, Mike Dragunow, Thomas I.-H. Park
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Effective cancer therapeutics for brain tumors must be able to cross the blood-brain barrier (BBB) to reach the tumor in adequate quantities and overcome the resistance conferred by the local tumor microenvironment. Clinically approved chemotherapeut
Externí odkaz:
https://doaj.org/article/f16ec4db14f14da6996120a8e137954f
Autor:
Peter Jaein Choi, Petr Tomek, Moana Tercel, Jóhannes Reynisson, Thomas In Hyeup Park, Elizabeth Alexandra Cooper, William Alexander Denny, Jiney Jose, Euphemia Leung
Publikováno v:
Molecules, Vol 27, Iss 3, p 880 (2022)
The CDK4/6 inhibitor palbociclib, combined with endocrine therapy, has been shown to be effective in postmenopausal women with estrogen receptor-positive, HER2-negative advanced or metastatic breast cancer. However, palbociclib is not as effective in
Externí odkaz:
https://doaj.org/article/e671aec5e09f4bc3b420e8a46419a8b3
Autor:
Julie A. Spicer, Kristiina M. Huttunen, Jiney Jose, Ivo Dimitrov, Hedieh Akhlaghi, Vivien R. Sutton, Ilia Voskoboinik, Joseph Trapani
Publikováno v:
Journal of Medicinal Chemistry. 65:14305-14325
New drugs that precisely target the immune mechanisms critical for cytotoxic T lymphocyte (CTL) and natural killer (NK) cell driven pathologies are desperately needed. In this perspective, we explore the cytolytic protein perforin as a target for the
Autor:
Elizabeth Cooper, Zoe Woolf, Molly E V Swanson, Jason Correia, Patrick Schweder, Edward Mee, Peter Heppner, Clinton Turner, Richard L M Faull, Emma L Scotter, William A Denny, Peter J Choi, Mike Dragunow, Jiney Jose, Thomas I-H Park
Publikováno v:
Neuro-oncology advances. 4(1)
Background Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults. Whilst the role of the efflux transporters are well established in GBM, the expression and function of uptake transporters, such as the organic anion trans
Autor:
Elizabeth Cooper, Peter J. Choi, Kihwan Hwang, Kyung M. Nam, Chae‐Yong Kim, Tina Shaban, Patrick Schweder, Edward Mee, Jason Correia, Clinton Turner, Richard L. M. Faull, William A. Denny, Katsuya Noguchi, Mike Dragunow, Jiney Jose, Thomas I.‐H. Park
Publikováno v:
Chemical biologydrug designREFERENCES.
The development of chemotherapies for glioblastoma is hindered by their limited bioavailability and toxicity on normal brain function. To overcome these limitations, we investigated the structure-dependent activity of heptamethine cyanine dyes (HMCD)
Autor:
Kate H. Gartlan, Jagdish K. Jaiswal, Matthew R. Bull, Hedieh Akhlaghi, Vivien R. Sutton, Kylie A. Alexander, Karshing Chang, Geoffrey R. Hill, Christian K. Miller, Patrick D. O’Connor, Jiney Jose, Joseph A. Trapani, Susan A. Charman, Julie A. Spicer, Stephen M. F. Jamieson
Publikováno v:
ACS pharmacologytranslational science. 5(6)
Perforin is a key effector of lymphocyte-mediated cell death pathways and contributes to transplant rejection of immunologically mismatched grafts. We have developed a novel series of benzenesulfonamide (BZS) inhibitors of perforin that can mitigate
Autor:
Elizabeth Alexandra Cooper, Peter J Choi, Kyung Mi Nam, Patrick Schweder, Edward Mee, Clinton Turner, Richard Faull, William A. Denny, Chae-Yong Kim, Mike Dragunow, Kihwan Hwang, Jiney Jose, Thomas I-H Park
Publikováno v:
WFNOS 2022 Abstract Book.