Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jindrich Cinatl Jr."'
Autor:
Sebastian Pieper, Hannah Onafuye, Dennis Mulac, Jindrich Cinatl Jr., Mark N. Wass, Martin Michaelis, Klaus Langer
Publikováno v:
Beilstein Journal of Nanotechnology, Vol 10, Iss 1, Pp 2062-2072 (2019)
Background: Nanoparticles are under investigation as carrier systems for anticancer drugs. The expression of efflux transporters such as the ATP-binding cassette (ABC) transporter ABCB1 is an important resistance mechanism in therapy-refractory cance
Externí odkaz:
https://doaj.org/article/8d1f5de7bcb549f99a9d63b4faf90618
Autor:
Hannah Onafuye, Sebastian Pieper, Dennis Mulac, Jindrich Cinatl Jr., Mark N. Wass, Klaus Langer, Martin Michaelis
Publikováno v:
Beilstein Journal of Nanotechnology, Vol 10, Iss 1, Pp 1707-1715 (2019)
Resistance to systemic drug therapy is a major reason for the failure of anticancer therapies. Here, we tested doxorubicin-loaded human serum albumin (HSA) nanoparticles in the neuroblastoma cell line UKF-NB-3 and its ABCB1-expressing sublines adapte
Externí odkaz:
https://doaj.org/article/5689f5d2bf47444c8e464bfaf5e9ac5a
Autor:
Martin Michaelis, Malte C. Kleinschmidt, Denisa Bojkova, Holger F. Rabenau, Mark N. Wass, Jindrich Cinatl Jr.
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Omeprazole was shown to improve the anti-cancer effects of the nucleoside analogue 5-fluorouracil. Here, we combined omeprazole with the antiviral nucleoside analogues ribavirin and acyclovir. Omeprazole did not affect the antiviral effects of ribavi
Externí odkaz:
https://doaj.org/article/3446ce4368304146a02ac62ec5a9fb9f
Autor:
Denisa Bojkova, Philipp Reus, Leona Panosch, Marco Bechtel, Tamara Rothenburger, Joshua D. Kandler, Annika Pfeiffer, Julian U.G. Wagner, Mariana Shumliakivska, Stefanie Dimmeler, Ruth Olmer, Ulrich Martin, Florian W.R. Vondran, Tuna Toptan, Florian Rothweiler, Richard Zehner, Holger F. Rabenau, Karen L. Osman, Steven T. Pullan, Miles W. Carroll, Richard Stack, Sandra Ciesek, Mark N. Wass, Martin Michaelis, Jindrich Cinatl, Jr.
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105944- (2023)
Summary: Reliable, easy-to-handle phenotypic screening platforms are needed for the identification of anti-SARS-CoV-2 compounds. Here, we present caspase 3/7 activity as a readout for monitoring the replication of SARS-CoV-2 isolates from different v
Externí odkaz:
https://doaj.org/article/4a88cf04c85349bf88133734b02945c5
Autor:
Andreas Wasilewicz, Benjamin Kirchweger, Denisa Bojkova, Marie Jose Abi Saad, Julia Langeder, Matthias Bütikofer, Sigrid Adelsberger, Ulrike Grienke, Jindrich Cinatl Jr., Olivier Petermann, Leonardo Scapozza, Julien Orts, Johannes Kirchmair, Holger F. Rabenau, Judith M. Rollinger
Publikováno v:
Journal of Natural Products, 86 (2)
In this study, an integrated in silico-in vitro approach was employed to discover natural products (NPs) active against SARS-CoV-2. The two SARS-CoV-2 viral proteases, i.e., main protease (Mpro) and papain-like protease (PLpro), were selected as targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a90f9060f46bb8491cdcda6433aa244a
Autor:
Martin Michaelis, Mark N. Wass, Ian Reddin, Yvonne Voges, Florian Rothweiler, Stephanie Hehlgans, Jaroslav Cinatl, Marco Mernberger, Andrea Nist, Thorsten Stiewe, Franz Rödel, Jindrich Cinatl Jr.
Publikováno v:
Cancers
Cancers, Vol 12, Iss 1080, p 1080 (2020)
Cancers, Vol 12, Iss 1080, p 1080 (2020)
Survivin is a drug target and its suppressant YM155 a drug candidate mainly investigated for high-risk neuroblastoma. Findings from one YM155-adapted subline of the neuroblastoma cell line UKF-NB-3 had suggested that increased ABCB1 (mediates YM155 e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d38c5c70b66e4827c343f4079d72ea91
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/54471
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/54471
The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1.
Autor:
Knecht, Kirsten M., Buzovetsky, Olga, Schneider, Constanze, Thomas, Dominique, Srikanth, Vishok Vishok, Kaderali, Lars, Tofoleanu, Florentina, Reiss, Krystle, Ferreirós, Nerea, Geisslinger, Gerd, Batista, Victor S., Xiaoyun Ji, Jindrich Cinatl, Jr., Keppler, Oliver T., Yong Xiong
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 10/23/2018, Vol. 115 Issue 43, pE10022-E10031, 10p
Autor:
Jindrich Cinatl Jr, Jaroslav Cinatl, Jens-U. Vogel, Holger Rabenau, Bernhard Kornhuber, Hans W. Doerr
Publikováno v:
Intervirology. 39:259-269
Although there is no definitive evidence of the association of human cytomegalovirus (HCMV) infection with human cancers, the oncogenic potential of HCMV has been well established by in vitro studies demonstrating the ability of UV-irradiated or infe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad99e03bca9ea3cc53aeee5461eace7a
https://doi.org/10.1159/000150527
https://doi.org/10.1159/000150527
Publikováno v:
Intervirology. 37:307-314
Effective therapy of human immunodeficiency virus (HIV) infection is mainly based on inhibition of reverse transcriptase by nucleoside analogues such as zidovudine (azidothymidine; AZT), didanosine, and zalcitabine. A major problem associated with lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b461cca44e5e35a209b7d402979c2c
https://doi.org/10.1159/000150394
https://doi.org/10.1159/000150394
Autor:
Shahana Dilruba, Alessia Grondana, Anke C. Schiedel, Naoto T. Ueno, Chandra Bartholomeusz, Jindrich Cinatl Jr, Katie-May McLaughlin, Mark N. Wass, Martin Michaelis, Ganna V. Kalayda
Publikováno v:
Cells, Vol 9, Iss 2, p 515 (2020)
The efficacy of cisplatin-based chemotherapy in ovarian cancer is often limited by the development of drug resistance. In most ovarian cancer cells, cisplatin activates extracellular signal-regulated kinase1/2 (ERK1/2) signalling. Phosphoprotein enri
Externí odkaz:
https://doaj.org/article/d7ca6759aa7441a4bb97161a2063f3b4