Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jindrich Cinatl, Jr."'
Autor:
Denisa Bojkova, Philipp Reus, Leona Panosch, Marco Bechtel, Tamara Rothenburger, Joshua D. Kandler, Annika Pfeiffer, Julian U.G. Wagner, Mariana Shumliakivska, Stefanie Dimmeler, Ruth Olmer, Ulrich Martin, Florian W.R. Vondran, Tuna Toptan, Florian Rothweiler, Richard Zehner, Holger F. Rabenau, Karen L. Osman, Steven T. Pullan, Miles W. Carroll, Richard Stack, Sandra Ciesek, Mark N. Wass, Martin Michaelis, Jindrich Cinatl, Jr.
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105944- (2023)
Summary: Reliable, easy-to-handle phenotypic screening platforms are needed for the identification of anti-SARS-CoV-2 compounds. Here, we present caspase 3/7 activity as a readout for monitoring the replication of SARS-CoV-2 isolates from different v
Externí odkaz:
https://doaj.org/article/4a88cf04c85349bf88133734b02945c5
Autor:
Roman A. Blaheta, Eva Weich, Dana Marian, Jürgen Bereiter-Hahn, Jon Jones, Dietger Jonas, Martin Michaelis, Hans Willhelm Doerr, Jindrich Cinatl, Jr.
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 8, Iss 10, Pp 807-816 (2006)
The genome, antigens of human cytomegalovirus (HCMV) are frequently found in prostatic carcinoma. However, whether this infection is causative or is an epiphenomenon is not clear. We therefore investigated the ability of HCMV to promote metastatic pr
Externí odkaz:
https://doaj.org/article/d648a29a29c34041a2e22ffe0d34f90e
Autor:
Jindrich Cinatl, Jr., Martin Michaelis, Pablo Hernáiz Drievert, Jaroslav Cinatl, Jan Hrabeta, Tatyana Suhan, Hans Wilhelm Doerr, Jens-Uwe Vogel
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 6, Iss 6, Pp 725-735 (2004)
The mode of the antitumoral activity of multimutated oncolytic herpes simplex virus type 1 G207 has not been fully elucidated yet. Because the antitumoral activity of many drugs involves the inhibition of tumor blood vessel formation, we determined i
Externí odkaz:
https://doaj.org/article/eac74f060b44471a87414303bafc4789
Autor:
Sebastian Pieper, Hannah Onafuye, Dennis Mulac, Jindrich Cinatl Jr., Mark N. Wass, Martin Michaelis, Klaus Langer
Publikováno v:
Beilstein Journal of Nanotechnology, Vol 10, Iss 1, Pp 2062-2072 (2019)
Background: Nanoparticles are under investigation as carrier systems for anticancer drugs. The expression of efflux transporters such as the ATP-binding cassette (ABC) transporter ABCB1 is an important resistance mechanism in therapy-refractory cance
Externí odkaz:
https://doaj.org/article/8d1f5de7bcb549f99a9d63b4faf90618
Autor:
Martin Michaelis, Malte C. Kleinschmidt, Denisa Bojkova, Holger F. Rabenau, Mark N. Wass, Jindrich Cinatl Jr.
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Omeprazole was shown to improve the anti-cancer effects of the nucleoside analogue 5-fluorouracil. Here, we combined omeprazole with the antiviral nucleoside analogues ribavirin and acyclovir. Omeprazole did not affect the antiviral effects of ribavi
Externí odkaz:
https://doaj.org/article/3446ce4368304146a02ac62ec5a9fb9f
Autor:
Andreas Wasilewicz, Benjamin Kirchweger, Denisa Bojkova, Marie Jose Abi Saad, Julia Langeder, Matthias Bütikofer, Sigrid Adelsberger, Ulrike Grienke, Jindrich Cinatl Jr., Olivier Petermann, Leonardo Scapozza, Julien Orts, Johannes Kirchmair, Holger F. Rabenau, Judith M. Rollinger
Publikováno v:
Journal of Natural Products, 86 (2)
In this study, an integrated in silico-in vitro approach was employed to discover natural products (NPs) active against SARS-CoV-2. The two SARS-CoV-2 viral proteases, i.e., main protease (Mpro) and papain-like protease (PLpro), were selected as targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a90f9060f46bb8491cdcda6433aa244a
Autor:
Shahana Dilruba, Alessia Grondana, Anke C. Schiedel, Naoto T. Ueno, Chandra Bartholomeusz, Jindrich Cinatl Jr, Katie-May McLaughlin, Mark N. Wass, Martin Michaelis, Ganna V. Kalayda
Publikováno v:
Cells, Vol 9, Iss 2, p 515 (2020)
The efficacy of cisplatin-based chemotherapy in ovarian cancer is often limited by the development of drug resistance. In most ovarian cancer cells, cisplatin activates extracellular signal-regulated kinase1/2 (ERK1/2) signalling. Phosphoprotein enri
Externí odkaz:
https://doaj.org/article/d7ca6759aa7441a4bb97161a2063f3b4
Autor:
Florian Rothweiler, Martin Michaelis, Peter Brauer, Jürgen Otte, Kristoffer Weber, Boris Fehse, Hans Wilhelm Doerr, Michael Wiese, Jörg Kreuter, Yousef Al-Abed, Ferdinando Nicoletti, Jindrich Cinatl, Jr
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 12, Pp 1023-1030 (2010)
The human immunodeficiency virus (HIV) protease inhibitor saquinavir shows anticancer activity. Although its nitric oxide-modified derivative saquinavir-NO (saq-NO) was less toxic to normal cells, it exerted stronger inhibition of B16 melanoma growth
Externí odkaz:
https://doaj.org/article/46cd24114d54441fb9c063d1539dde6a
Autor:
Roman A. Blaheta, Maciej Powerski, Lukasz Hudak, Eva Juengel, Dietger Jonas, Andreas von Knethen, Hans Willhelm Doerr, Jindrich Cinatl, Jr
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 11, Iss 10, Pp 1054-1063 (2009)
Tumor cells have evolved effective strategies to escape the host immune response. The objective of this study was to determine whether tumor cells can condition endothelial cells in a specific manner to prevent subsequent adhesion of polymorphonuclea
Externí odkaz:
https://doaj.org/article/85d7a83bb2a04a66acc1d214f236682a
Autor:
Martin Michaelis, Mark N. Wass, Ian Reddin, Yvonne Voges, Florian Rothweiler, Stephanie Hehlgans, Jaroslav Cinatl, Marco Mernberger, Andrea Nist, Thorsten Stiewe, Franz Rödel, Jindrich Cinatl Jr.
Publikováno v:
Cancers
Cancers, Vol 12, Iss 1080, p 1080 (2020)
Cancers, Vol 12, Iss 1080, p 1080 (2020)
Survivin is a drug target and its suppressant YM155 a drug candidate mainly investigated for high-risk neuroblastoma. Findings from one YM155-adapted subline of the neuroblastoma cell line UKF-NB-3 had suggested that increased ABCB1 (mediates YM155 e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d38c5c70b66e4827c343f4079d72ea91
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/54471
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/54471