Zobrazeno 1 - 10
of 334
pro vyhledávání: '"Jincun, Zhao"'
Autor:
Jun Liu, Gary Wong, Hui Li, Yan Yang, Yuxi Cao, Yongfeng Li, Yan Wu, Zijie Zhang, Cong Jin, Xi Wang, Yongwen Chen, Bin Su, Zhongfang Wang, Qihui Wang, Yunlong Cao, Guobing Chen, Zhaohui Qian, Jincun Zhao, Guizhen Wu
Publikováno v:
Biosafety and Health, Vol 6, Iss 5, Pp 310-318 (2024)
Biosafety hazards can trigger a host immune response after infection, invasion, or contact with the host. Whether infection with a microorganism results in disease or biosafety concerns depends to a large extent on the immune status of the population
Externí odkaz:
https://doaj.org/article/62e4d896bcac4927be6f6a542b17edb4
Autor:
Feng Wang, Tiancheng Ma, Donglan Liu, Yixin Cen, Shidong Deng, Lu Zhang, Guoqiang Lin, Dingding Gao, Jincun Zhao, Jiajia Dong, Ping Tian
Publikováno v:
Acta Materia Medica, Vol 3, Iss 3, Pp 328-344 (2024)
The 3C-like protease (3CLpro) is a crucial target in anti-Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) drug design. Herein, we performed high-throughput synthesis of catechol derivatives from the bioactive catechol-terminal alkyne sca
Externí odkaz:
https://doaj.org/article/c1b1dac4620848068740f5f672bacf6d
Autor:
Qihong Yan, Xijie Gao, Banghui Liu, Ruitian Hou, Ping He, Yong Ma, Yudi Zhang, Yanjun Zhang, Zimu Li, Qiuluan Chen, Jingjing Wang, Xiaohan Huang, Huan Liang, Huiran Zheng, Yichen Yao, Xianying Chen, Xuefeng Niu, Jun He, Ling Chen, Jincun Zhao, Xiaoli Xiong
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Continued evolution of SARS-CoV-2 generates variants to challenge antibody immunity established by infection and vaccination. A connection between population immunity and genesis of virus variants has long been suggested but its molecular ba
Externí odkaz:
https://doaj.org/article/8b39b6be46864368911fc0a43d056643
Autor:
Canjie Chen, Tian Tang, Zhao Chen, Lan Chen, Jinling Cheng, Fang Li, Jing Sun, Jingxian Zhao, Yanqun Wang, Qihong Yan, Jincun Zhao, Airu Zhu
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 20, Iss 1 (2024)
The COVID-19 pandemic has underscored vaccination as a crucial strategy for reducing disease severity and preventing hospitalizations. Heterologous boosters using aerosolized Ad5-nCoV following two doses of inactivated vaccine have demonstrated super
Externí odkaz:
https://doaj.org/article/0f983c03810e411a8a1b2a3f7d205a27
Autor:
Qihong Yan, Yudi Zhang, Ruitian Hou, Wenjing Pan, Huan Liang, Xijie Gao, Weiqi Deng, Xiaohan Huang, Linbing Qu, Congli Tang, Ping He, Banghui Liu, Qian Wang, Xinwei Zhao, Zihan Lin, Zhaoming Chen, Pingchao Li, Jian Han, Xiaoli Xiong, Jincun Zhao, Song Li, Xuefeng Niu, Ling Chen
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
Neutralizing antibodies are a key component in protective humoral immunity against SARS-CoV-2. Currently, available technologies cannot track epitope-specific antibodies in global antibody repertoires. Thus, the comprehensive repertoire of spike-spec
Externí odkaz:
https://doaj.org/article/eeb0f95471004ba78c322e91588a98fe
Autor:
Airu Zhu, Liang Zhou, Zhao Chen, Dongdong Liu, Huijian Feng, Baomei Cai, Xinwen Chen, Jincun Zhao, Jingxian Zhao, Jiekai Chen, Manshu Li, Jiangping He
Publikováno v:
Heliyon, Vol 10, Iss 19, Pp e38688- (2024)
The vastly spreading COVID-19 pneumonia is caused by SARS-CoV-2. Lymphopenia and cytokine levels are tightly associated with disease severity. However, virus-induced immune dysregulation at cellular and molecular levels remains largely undefined. Her
Externí odkaz:
https://doaj.org/article/6e7925febf3a49e8a2bbb410811577ae
Autor:
Yuzheng Zhou, Zongpeng Chen, Sijie Liu, Sixu Liu, Yujie Liao, Ashuai Du, Zijun Dong, Yongxing Zhang, Xuan Chen, Siyi Tao, Xin Wu, Aroona Razzaq, Gang Xu, De-an Tan, Shanni Li, Youwen Deng, Jian Peng, Shuyan Dai, Xu Deng, Xianwen Zhang, Taijiao Jiang, Zheng Zhang, Gong Cheng, Jincun Zhao, Zanxian Xia
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-18 (2024)
Abstract The ORF9b protein, derived from the nucleocapsid’s open-reading frame in both SARS-CoV and SARS-CoV-2, serves as an accessory protein crucial for viral immune evasion by inhibiting the innate immune response. Despite its significance, the
Externí odkaz:
https://doaj.org/article/72c1fb80cf934c1d91f4910ac813a63b
Autor:
Yingdan Wang, Aihua Hao, Ping Ji, Yunping Ma, Zhaoyong Zhang, Jiali Chen, Qiyu Mao, Xinyi Xiong, Palizhati Rehati, Yajie Wang, Yanqun Wang, Yumei Wen, Lu Lu, Zhenguo Chen, Jincun Zhao, Fan Wu, Jinghe Huang, Lei Sun
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The Omicron subvariants BQ.1.1, XBB.1.5, and XBB.1.16 of SARS-CoV-2 are known for their adeptness at evading immune responses. Here, we isolate a neutralizing antibody, 7F3, with the capacity to neutralize all tested SARS-CoV-2 variants, inc
Externí odkaz:
https://doaj.org/article/1baaece47e9e413588ae2c3a07909406
Autor:
Shengjun Wang, Wei Ran, Lingyu Sun, Qingchi Fan, Yuanqi Zhao, Bowen Wang, Jinghong Yang, Yuqi He, Ying Wu, Yuanyuan Wang, Luoyi Chen, Arpaporn Chuchuay, Yuyu You, Xinhai Zhu, Xiaojuan Wang, Ye Chen, Yanqun Wang, Yao-Qing Chen, Yanqiu Yuan, Jincun Zhao, Yang Mao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The multibasic furin cleavage site at the S1/S2 boundary of the spike protein is a hallmark of SARS-CoV-2 and plays a crucial role in viral infection. However, the mechanism underlying furin activation and its regulation remain poorly unders
Externí odkaz:
https://doaj.org/article/7db3930eb94b4fa9b117d83986ce71a3
Autor:
Hao Meng, Zhiying Liao, Yanting Ji, Dong Wang, Yang Han, Chaolin Huang, Xujuan Hu, Jingyi Chen, Hengrui Zhang, Zonghong Li, Changliang Wang, Hui Sun, Jiaqi Sun, Lihua Chen, Jiaxiang Yin, Jincun Zhao, Tao Xu, Huisheng Liu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-15 (2024)
Abstract The angiotensin-converting enzyme 2 (ACE2) is a primary cell surface viral binding receptor for SARS-CoV-2, so finding new regulatory molecules to modulate ACE2 expression levels is a promising strategy against COVID-19. In the current study
Externí odkaz:
https://doaj.org/article/e844022f63894ad3bd43c2f333cac2d5