Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Jinbo Lee"'
Autor:
Seungkyu Lee, Sooyeon Jo, Sébastien Talbot, Han-Xiong Bear Zhang, Masakazu Kotoda, Nick A Andrews, Michelino Puopolo, Pin W Liu, Thomas Jacquemont, Maud Pascal, Laurel M Heckman, Aakanksha Jain, Jinbo Lee, Clifford J Woolf, Bruce P Bean
Publikováno v:
eLife, Vol 8 (2019)
Voltage-dependent sodium and calcium channels in pain-initiating nociceptor neurons are attractive targets for new analgesics. We made a permanently charged cationic derivative of an N-type calcium channel-inhibitor. Unlike cationic derivatives of lo
Externí odkaz:
https://doaj.org/article/de64bb25275445b0a3e4407fe3462af5
Autor:
Bernard Meunier, Gary Brudvig, Jennifer L Mclain, Shun-ichi Murahashi, V L Pecoraro, D Riley, Anne Robert, J A Rodriguez, R A Sheldon, J S Valentine, C Young, James M Mayer, Julian Limburg, Jinbo Lee, Diane Cabelli, R H Crabtree, Sergiu M Gorun, John T Groves, Zhengbo Hu, K U Ingold, Kenneth D Karlin, Naruyoshi Komiya, Marie-aude Kopf, Hans Jorg Krueger, H Zhu
Since the classic work Metal-Catalyzed Oxidations of Organic Compounds (edited by R A Sheldon and J K Kochi, 1991), no book has been devoted to advances in the field of biomimetic oxidations, which was created nearly 18 years ago. This expanding rese
Autor:
Clifford J. Woolf, Stephen M. Jordan, Benjamin Doyle, Sébastien Talbot, Jaehoon Shim, Louise Haste, Ivan Tochitsky, Jinbo Lee, Nick Andrews, Bruce D. Levy, David A. Roberson, Masakazu Kotoda, Bruce P. Bean, Sooyeon Jo
Publikováno v:
Br J Pharmacol
Background and Purpose: Many pain-triggering nociceptor neurons express TRPV1 or TRPA1, cation-selective channels with large pores that enable permeation of QX-314, a cationic analogue of lidocaine. Co-application of QX-314 with TRPV1 or TRPA1 activa
Autor:
Benjamin Doyle, Ivan Tochitsky, David A. Roberson, Stephen M. Jordan, Louise Haste, Nick Andrews, Sébastien Talbot, Clifford J. Woolf, Bruce D. Levy, Jaehoon Shim, Jinbo Lee, Sooyeon Jo, Bruce P. Bean, Masakazu Kotoda
Although multiple diseases of the respiratory system cause cough, there are few effective treatments for this common condition. We previously developed a strategy to treat pain and itch via the long-lasting inhibition of nociceptor sensory neurons wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::328c541124b5b958edb42c7b7763a1c6
https://doi.org/10.1101/2020.12.07.414763
https://doi.org/10.1101/2020.12.07.414763
Autor:
Masakazu Kotoda, Aakanksha Jain, Michelino Puopolo, Clifford J. Woolf, Nick Andrews, Sooyeon Jo, Thomas Jacquemont, Jinbo Lee, Han-Xiong Bear Zhang, Laurel M. Heckman, Maud Pascal, Sébastien Talbot, Bruce P. Bean, Pin W. Liu, Seungkyu Lee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f248ef109b663ee9e8597550bb1d46d
https://doi.org/10.7554/elife.48118.sa2
https://doi.org/10.7554/elife.48118.sa2
Autor:
Thomas Jacquemont, Masakazu Kotoda, Clifford J. Woolf, Laurel M. Heckman, Nick Andrews, Bruce P. Bean, Seungkyu Lee, Han-Xiong Bear Zhang, Michelino Puopolo, Sooyeon Jo, Sébastien Talbot, Maud Pascal, Aakanksha Jain, Jinbo Lee, Pin W. Liu
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
Voltage-dependent sodium and calcium channels in pain-initiating nociceptor neurons are attractive targets for new analgesics. We made a permanently charged cationic derivative of an N-type calcium channel-inhibitor. Unlike cationic derivatives of lo
Autor:
Bruce Follows, Steve J. Kirincich, Jinbo Lee, Douglas P. Wilson, Diane Joseph-McCarthy, David V. Erbe, James Tobin, Yan-Ling Zhang, Tam Steve Yik-Kai, Zhao-Kui Wan, Eva Binnun, Wei Li, Rajeev Hotchandani, Junjun Wu, Tarek S. Mansour, Weixin Xu, Manus Ipek, May Tam, Alessandro Moretto
Publikováno v:
ChemMedChem. 3:1525-1529
Autor:
Jinbo Lee, Junjun Wu, Yan-Ling Zhang, Zhao-Kui Wan, May Tam, David V. Erbe, Doug Wilson, James Tobin, Steven J. Kirincich
Publikováno v:
Analytical Biochemistry. 365:174-184
Considerable effort exists within drug discovery to develop novel compounds to improve the underlying metabolic defects in type 2 diabetes. One approach is focused on inhibition of the tyrosine phosphatase, PTP1B, an important negative regulator of b
Autor:
Yan-Ling Zhang, Zhao-Kui Wan, Eddine Saiah, David V. Erbe, Tam Steve Yik-Kai, Junjun Wu, Eva Binnun, May Tam, Diane Joseph-McCarthy, Jinbo Lee, Steven J. Kirincich, Weixin Xu, Bruce Follows, Michael F. Smith, Douglas P. Wilson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2913-2920
The following account describes our systematic effort to replace one of the carboxylate groups of our diacid thiophene PTP1B inhibitors. Active hits were validated using enzymatic assays before pursuing efforts to improve the potency. Only when the C
Autor:
Bruce Follows, Yan-Ling Zhang, Zhao-Kui Wan, David V. Erbe, Diane Joseph-McCarthy, Weixin Xu, Jinbo Lee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:4941-4945
A series of monocyclic thiophenes was designed and synthesized as PTP1B inhibitors. Guided by X-ray co-crystal structural information and computational modeling, rational design led to key interactions with Asp48 and improved inhibitory potency again