Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Jina Kazzaz"'
Autor:
Daniele Casini, Barbara Baudner, Vanessa Ronconi, Marco Tortoli, Jina Kazzaz, Derek T. O'Hagan, Lynn D. Hawkins, Manmohan Singh, Andreas Wack
Publikováno v:
Pharmaceutical Research. 26:1477-1485
The effectiveness of vaccines depends on the age and immunocompetence of the vaccinee. Conventional non-adjuvanted influenza vaccines are suboptimal in the elderly and vaccines with improved ability to prevent influenza are required. The TLR4 agonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543292b844b14ec37c1d64c07425cd6a
https://doi.org/10.1007/s11095-009-9859-5
https://doi.org/10.1007/s11095-009-9859-5
Autor:
Manmohan Singh, Jina Kazzaz, Mildred Ugozzoli, Claire Madden, James Chesko, Derek T. O'Hagan, Nikin Patel, Mark Perkins
Publikováno v:
Journal of Pharmaceutical Sciences. 97:1443-1453
The chemical composition of the surface of anionic PLG microparticles before and after adsorption of vaccine antigens was measured using X-ray photoelectron spectroscopy (XPS) and time-of-flight secondary ion mass spectrometry (TOF-SIMS). The interfa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b74e1e734c965475c8917325e4cc9d1
https://doi.org/10.1002/jps.21040
https://doi.org/10.1002/jps.21040
Autor:
Mildred Ugozzoli, Simona Tavarini, Sandra Nuti, Manmohan Singh, Emanuele Montomoli, Barbara Baudner, Hanno Scheffczik, Jina Kazzaz, Rino Rappuoli, Andreas Wack, Ilaria Manini, Derek T. O'Hagan, Giuseppe Del Giudice, Anne Katrin Hilbert
Publikováno v:
Vaccine. 26:552-561
Influenza is controlled by protective titres of neutralizing antibodies, induced with the help of CD4 T-cells, and by antiviral T-cell effector function. Adjuvants are essential for the efficient vaccination of a naïve population against avian influ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed041173efa6f0829c750c51ad6ebc12
https://doi.org/10.1016/j.vaccine.2007.11.054
https://doi.org/10.1016/j.vaccine.2007.11.054
Autor:
Rebecca Wei, Jina Kazzaz, Raj Dhaliwal, Derek T. O'Hagan, James Chesko, Maninder S. Hora, Mildred Ugozzoli, Jia-Hwa Fang, Manmohan Singh, Padma Malyala
Publikováno v:
International Journal of Pharmaceutics. 327:1-5
We have previously shown that cationic polylactide-co-glycolide (PLG) microparticles can be effectively used to adsorb DNA and generate potent immune responses in vivo. We now describe a modified and easier process containing a single lyophilization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd9350c929e41fc77e3f87bfaf6cce66
https://doi.org/10.1016/j.ijpharm.2006.07.033
https://doi.org/10.1016/j.ijpharm.2006.07.033
Autor:
Angelica Medina-Selby, Steve Nguyen, Derek T. O'Hagan, Doris Coit, Michael Vajdy, Domenico Rosa, Michael Houghton, Sergio Abrignani, Laura Tandeske, Philip Ng, Manmohan Singh, David Y. Chien, Steve Coates, Hall John A, Jina Kazzaz, Mark J. Selby, Celine Hu, Yin-Ling Lin
Publikováno v:
Journal of General Virology. 87:2253-2262
Although approximately 3 % of the world's population is infected withHepatitis C virus(HCV), there is no prophylactic vaccine available. This study reports the design, cloning and purification of a single polyprotein comprising the HCV core protein a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6b3977c14c9e0f1bceac8a3344d10d2
https://doi.org/10.1099/vir.0.81849-0
https://doi.org/10.1099/vir.0.81849-0
Autor:
James Chesko, Manmohan Singh, Jina Kazzaz, Mildred Ugozzoli, Elawati Soenawan, Derek T. O'Hagan
Publikováno v:
Journal of Controlled Release. 110:566-573
Purpose: Monophosphoryl lipid A (MPL) and the synthetic LPS mimetic RC529, encapsulated in poly(lactide-co-glycolide) (PLG) microparticles, were evaluated as immune potentiators in the presence of either HIV-1 gp120 protein or antigen from Neisseria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad2d103d7a20c4e71b7b036ea053cef
https://doi.org/10.1016/j.jconrel.2005.10.010
https://doi.org/10.1016/j.jconrel.2005.10.010
Autor:
Derek T. O'Hagan, James Chesko, Mildred Ugozzoli, Jina Kazzaz, Manmohan Singh, Indresh K. Srivastava, Elaine Kan
Publikováno v:
Pharmaceutical Research. 21:2148-2152
To evaluate the delivery of a novel HIV-1 antigen (gp120dV2 SF162) by surface adsorption or encapsulation within polylactide-co-glycolide microparticles and to compare both the formulations for their ability to preserve functional activity as measure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19a1a2d04b91ea3fc8443430fb6f618b
https://doi.org/10.1007/s11095-004-7666-6
https://doi.org/10.1007/s11095-004-7666-6
Publikováno v:
Expert Opinion on Biological Therapy. 4:483-491
Polymeric microparticles with encapsulated antigens have become well-established in the last decade as potent antigen delivery systems and adjuvants, with experience being reported from many groups. However, the authors have recently shown that an al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3168ce6351fda01ce679242edf09ab24
https://doi.org/10.1517/14712598.4.4.483
https://doi.org/10.1517/14712598.4.4.483
Autor:
Ramesh Janani, Vijay Shreedhar, Jina Kazzaz, Manmohan Singh, Soumi Gupta, Elawati Soenawan, Michael Vajdy, Indresh K. Srivastava, Elaine Kan
Publikováno v:
Vaccine. 22:1553-1563
To understand the mechanisms involved in maintaining long-term immunological memory following mucosal immunizations, we determined the quality of serum hapten-specific immunoglobulins (Ig) and localized Ig-secreting cells (SC) of various isotypes in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a4df00f5316b2bf30951fa8387fc770
https://doi.org/10.1016/j.vaccine.2003.10.018
https://doi.org/10.1016/j.vaccine.2003.10.018
Autor:
Manmohan Singh, Paolo Ruggiero, Jina Kazzaz, Giuseppe Del Giudice, Maylene Briones, Mildred Ugozzoli, Michael Vajdy, Lina Cuadra, Elawati Soenawan, Derek T. O'Hagan, Samuele Peppoloni, Francesco Norelli
Publikováno v:
Immunology. 110:86-94
Summary It is estimated that Helicobacter pylori infects the stomachs of over 50% of the world's population and if not treated may cause chronic gastritis, peptic ulcer disease, gastric adenocarcinoma and gastric B-cell lymphoma. The aim of this stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a69846e85a1d9b8c6bb4092605e1e237
https://doi.org/10.1046/j.1365-2567.2003.01711.x
https://doi.org/10.1046/j.1365-2567.2003.01711.x