Zobrazeno 1 - 7
of 7
pro vyhledávání: '"JinMing Guan"'
Publikováno v:
Asian Journal of Surgery, Vol 47, Iss 10, Pp 4537-4538 (2024)
Externí odkaz:
https://doaj.org/article/6b8f4f3243cf4e70ab6e39af36ee1e66
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 963-968 (2016)
Pantothenamides are known for their in vitro antimicrobial activity. Our group has previously reported a new stereoselective route to access derivatives modified at the geminal dimethyl moiety. This route however fails in the addition of large substi
Externí odkaz:
https://doaj.org/article/dbcf183f61cc4d72b14659b3a1196afe
Autor:
Jinming Guan, Tanakorn Kittikool, Harriet Ling, Vanessa M. Howieson, Kevin J. Saliba, Karine Auclair, Erick T. Tjhin, Gaetan Burgio, Christina Spry, Lora Starrs, Dustin Duncan, Penghui Yang
Publikováno v:
Journal of Medicinal Chemistry. 64:4478-4497
The Plasmodium parasites that cause malaria are adept at developing resistance to antimalarial drugs, necessitating the search for new antiplasmodials. Although several amide analogs of pantothenate (pantothenamides) show potent antiplasmodial activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb191dfb00ce17d056e455a619564b07
https://doi.org/10.1021/acs.jmedchem.0c01755
https://doi.org/10.1021/acs.jmedchem.0c01755
Publikováno v:
Analytical chemistry. 91(18)
Kinases are widely distributed in nature and are implicated in many human diseases. Thus, an understanding of their activity and regulation is of fundamental importance. Several kinases are known to be inhibited by ADP. However, thorough investigatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f1feefa397924e449250c2fb9ad1c59
https://pubmed.ncbi.nlm.nih.gov/31426630
https://pubmed.ncbi.nlm.nih.gov/31426630
Autor:
Vanessa M. Howieson, Christina Spry, Kevin J. Saliba, Karine Auclair, Erick T. Tjhin, Tanakorn Kittikool, Jinming Guan
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Pantothenamides are potent growth inhibitors of the malaria parasite Plasmodium falciparum. Their clinical use is, however, hindered due to the ubiquitous presence of pantetheinases in human serum, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f297969656086d23e9a9dc60f6eb3c3f
https://hdl.handle.net/10453/131027
https://hdl.handle.net/10453/131027
Autor:
Jeanne Cresson, Erick Strauss, Jinming Guan, Karine Auclair, Justin H. Chang, Leanne Barnard, Annabelle Hoegl
Publikováno v:
Bioorganicmedicinal chemistry. 26(22)
Pantothenate kinase (PanK) catalyzes the transformation of pantothenate to 4′-phosphopantothenate, the first committed step in coenzyme A biosynthesis. While numerous pantothenate antimetabolites and PanK inhibitors have been reported for bacterial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47cfbcf1724c84f16e63a4e96fe8b914
https://pubmed.ncbi.nlm.nih.gov/30429095
https://pubmed.ncbi.nlm.nih.gov/30429095
Publikováno v:
Chembiochem : a European journal of chemical biology. 19(19)
Aminoglycosides are a group of broad-spectrum antibiotics that have been used in the clinic for almost a century. The rapid spread of bacterial genes coding for aminoglycoside-modifying enzymes has, however, dramatically decreased the utility of amin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::107f7c7f1483e86597bf3a368cb1cfab
https://pubmed.ncbi.nlm.nih.gov/30059603
https://pubmed.ncbi.nlm.nih.gov/30059603